Biotechnology

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at different points, researchers can now watch damage flare up, track repair proteins rushing to the site, and see the moment the DNA is restored. Built from a natural protein that binds gently and briefly to damaged DNA, the sensor offers a true-to-life view of the cell’s internal emergency response.

Worker bees stage coordinated revolts when viral infections weaken their queen and lower her pheromone output. This disruption drives many of the queen failures that beekeepers struggle with today. Field trials show that synthetic pheromone blends can prevent untimely supersedure, opening a path to more stable hive management.

Scientists used CRISPR to boost the efficiency and digestibility of a fungus already known for its meatlike qualities. The modified strain grows protein far more quickly and with much less sugar while producing substantially fewer emissions. It also outperforms chicken farming in land use and water impact.

Researchers have recreated a miniature human bone marrow system that mirrors the real structure found inside our bones. The model includes the full mix of cells and signals needed for blood production and even maintains this process for weeks. It could transform how scientists study blood cancers and test new drugs. In the future, it may support more personalized treatment strategies.

Massive Sargassum blooms sweeping across the Caribbean and Atlantic are fueled by a powerful nutrient partnership: phosphorus pulled to the surface by equatorial upwelling and nitrogen supplied by cyanobacteria living directly on the drifting algae. Coral cores reveal that this nutrient engine has intensified over the past decade, perfectly matching surges in Sargassum growth since 2011. By ruling out older theories involving Saharan dust and river runoff, researchers uncovered a climate-driven process that shapes when and where these colossal seaweed mats form.

Scientists are turning venom, radioisotopes, engineered proteins, and AI into powerful new tools against cancer. From Amazonian scorpions yielding molecules that kill breast cancer cells as effectively as chemotherapy, to improved fibrin sealants and custom-grown bioactive factors, researchers are pushing biotechnology into uncharted territory. Parallel teams are advancing radiotheranostics that diagnose and destroy tumors with precision, while others forge experimental vaccines that train the immune system using hybrid dendritic cells.

Researchers have sequenced the oldest RNA ever recovered, taken from a woolly mammoth frozen for nearly 40,000 years. The RNA reveals which genes were active in its tissues, offering a rare glimpse into its biology and final moments. Surprisingly, the team also identified ancient microRNAs and rare mutations that confirm their mammoth origin. The finding shows that RNA can endure millennia—reshaping how scientists study extinct species.

Scientists studying aging found that sensory inputs like touch and smell can cancel out the lifespan-boosting effects of dietary restriction by suppressing the key longevity gene fmo-2. When overactivated, the gene makes worms oddly indifferent to danger and food, suggesting trade-offs between lifespan and behavior. The work highlights how deeply intertwined the brain, metabolism, and environment are. These pathways may eventually be targeted to extend life without extreme dieting.

Scientists at EPFL have unraveled the mystery behind why biological nanopores, tiny molecular holes used in both nature and biotechnology, sometimes behave unpredictably. By experimenting with engineered versions of the bacterial pore aerolysin, they discovered that two key effects, rectification and gating, stem from the pore’s internal electrical charges and their interaction with passing ions. The team even built nanopores that imitate brain-like “learning,” hinting at future applications in bio-inspired computing and ion-based processors.

Japanese researchers uncovered a universal rule describing why life’s growth slows despite abundant nutrients. Their “global constraint principle” integrates classic biological laws to show that multiple factors limit cellular growth in sequence. Verified through E. coli simulations, it provides a powerful new lens for studying living systems. The work could boost crop yields and biomanufacturing efficiency.

Researchers from the University of Vienna discovered MISO bacteria that use iron minerals to oxidize toxic sulfide, creating energy and producing sulfate. This biological process reshapes how scientists understand global sulfur and iron cycles. By outpacing chemical reactions, these microbes could help stop the spread of oceanic dead zones and maintain ecological balance.

Deep beneath the ocean, scientists uncovered thriving microbial life in one of Earth’s harshest environments—an area with a pH of 12, where survival seems nearly impossible. Using lipid biomarkers instead of DNA, researchers revealed how these microbes persist by metabolizing methane and sulfate. The discovery not only sheds light on deep-sea carbon cycling but also suggests that life may have originated in similar extreme conditions, offering a glimpse into both Earth’s past and the limits of life itself.

Beneath the ocean’s surface, bacteria have evolved specialized enzymes that can digest PET plastic, the material used in bottles and clothes. Researchers at KAUST discovered that a unique molecular signature distinguishes enzymes capable of efficiently breaking down plastic. Found in nearly 80% of ocean samples, these PETase variants show nature’s growing adaptation to human pollution.

A collaboration between Brazilian and German researchers has led to a sunflower-based meat substitute that’s high in protein and minerals. The new ingredient, made from refined sunflower flour, delivers excellent nutritional value and a mild flavor. Tests showed strong texture and healthy fat content, suggesting great potential for use in the growing plant-based food sector.

Researchers at UC San Diego have figured out how to get bacteria to produce xanthommatin, the pigment that lets octopuses and squids camouflage. By linking the pigment’s production to bacterial survival, they created a self-sustaining system that boosts yields dramatically. This biotechnological leap could revolutionize materials science, cosmetics, and sustainable chemistry.

Penn State scientists uncovered an ancient bacterial defense where dormant viral DNA helps bacteria fight new viral threats. The enzyme PinQ flips bacterial genes to create protective proteins that block infection. Understanding this mechanism could lead to breakthroughs in antivirals, antibiotic alternatives, and industrial microbiology.

A pandemic-era breakthrough has allowed scientists to literally expand our view of plankton. By using ultrastructure expansion microscopy, researchers visualized the inner workings of hundreds of marine species for the first time. The effort, tied to the TREC expedition, maps the evolutionary architecture of life’s smallest ocean dwellers. It’s the start of a global atlas revealing how complexity evolved beneath the waves.

Fungi’s evolutionary roots stretch far deeper than once believed — up to 1.4 billion years ago, long before plants or animals appeared. Using advanced molecular dating and gene transfer analysis, researchers reconstructed fungi’s ancient lineage, revealing they were crucial in shaping Earth’s first soils and ecosystems.

MIT researchers discovered that the genome’s 3D structure doesn’t vanish during cell division as previously thought. Instead, tiny loops called microcompartments remain (and even strengthen) while chromosomes condense. These loops may explain the brief surge of gene activity that occurs during mitosis. The finding redefines how scientists understand the balance between structure and function in dividing cells.

Naked mole-rats seem to have found nature’s cheat code for longevity. Scientists discovered that small tweaks in one of their proteins make it better at fixing DNA damage, helping the animals resist aging. Even fruit flies with the same changes lived longer, hinting at a universal way life can extend its own clock. It’s a glimpse into how evolution fine-tunes biology to fight time itself.

Researchers have developed a light-emitting sugar probe that exposes how marine microbes break down complex carbohydrates. The innovative fluorescent tool allows scientists to visualize when and where sugars are degraded in the ocean. This breakthrough helps map microbial activity and carbon cycling, providing new clues about how the ocean stores and releases carbon.

EMBL researchers created SDR-seq, a next-generation tool that decodes both DNA and RNA from the same cell. It finally opens access to non-coding regions, where most disease-associated genetic variants lie. By revealing how these variants affect gene activity, scientists can better understand complex diseases and develop improved diagnostic tools.

Scientists discovered true teeth growing on the head of the spotted ratfish, a distant shark relative. The toothed structure, called a tenaculum, helps males hold onto females during mating. Genetic evidence shows these head teeth share the same origins as oral teeth, overturning assumptions that teeth only evolve in jaws. This discovery reshapes the story of dental evolution across vertebrates.

Researchers have cracked the code behind how plants make mitraphylline, a rare cancer-fighting molecule. Their discovery of two critical enzymes explains how nature builds complex spiro-shaped compounds. The work paves the way for sustainable, lab-based production of valuable natural medicines. Supported by international collaborations, the findings spotlight plants as powerful natural chemists.

Scientists studying tiny roundworms have uncovered how the secrets of a long life can be passed from parents to their offspring — without changing DNA. The discovery shows that when certain cellular structures called lysosomes change in ways that promote longevity, those benefits can travel from body cells to reproductive cells. This information is carried by histones, special proteins that help organize DNA, allowing the “memory” of those changes to be inherited.

Fungi may have shaped Earth’s landscapes long before plants appeared. By combining rare gene transfers with fossil evidence, researchers have traced fungal origins back nearly a billion years earlier than expected. These ancient fungi may have partnered with algae, recycling nutrients, breaking down rock, and creating primitive soils. Far from being silent background players, fungi were ecosystem engineers that prepared Earth’s surface for plants, fundamentally altering the course of life’s history.

Scientists have discovered that pollen is a hidden source of natural medicine for honeybees. Symbiotic bacteria called Streptomyces produce antimicrobial compounds that fight deadly bee and plant pathogens. Bees collect these bacteria along with pollen and store them in hives, creating a natural defense system. This could lead to new, sustainable ways of protecting both pollinators and crops.

A team of researchers tested morin, a plant compound, against gum disease bacteria and found strong antimicrobial benefits. By encapsulating it in polymers, they created a powdered form for oral hygiene products. This could replace antibiotics, avoid side effects from existing treatments, and help vulnerable patients maintain oral health.

Researchers have revealed how polymyxins, crucial last-resort antibiotics, break down bacterial armor by forcing cells to overproduce and shed it. Astonishingly, the drugs only kill bacteria when they’re active, leaving dormant cells untouched. This discovery could explain recurring infections and inspire strategies to wake bacteria up before treatment.

Human fertility hinges on a delicate molecular ballet that begins even before birth. UC Davis researchers have uncovered how special protein networks safeguard chromosomes as eggs and sperm form, ensuring genetic stability across generations. Using yeast as a model, they revealed how crossovers between chromosomes are protected for decades in female eggs, preventing errors that could lead to infertility, miscarriage, or conditions like Down syndrome.

Researchers found that magic mushrooms and fiber caps independently evolved different biochemical pathways to create psilocybin. This convergence shows nature’s ingenuity, but the reason why remains unknown—possibly predator deterrence. Beyond evolutionary mystery, the discovery provides new enzyme tools for biotech, with promising applications for producing psilocybin-based medicines.

In Jezero Crater’s Bright Angel formation, Perseverance has found rocks rich in organic molecules and minerals linked to microbial metabolism. Their arrangement hints at redox reactions that resemble Earth’s life-driven chemistry. While not proof of Martian life, the findings qualify as “potential biosignatures” and make the stored sample a top candidate for return to Earth.

Researchers uncovered how ants keep their powerful sense of smell clear: by using a genetic safeguard that silences surrounding receptor genes. This discovery not only solves a decades-old puzzle but also reveals how ants can rapidly evolve new olfactory abilities.

A team from the University of Illinois has uncovered surprising evolutionary links between the genetic code and tiny protein fragments called dipeptides. By analyzing billions of dipeptide sequences across thousands of species, the researchers revealed that these molecular pairs trace the earliest steps in the origin of life.

Scientists at Cold Spring Harbor Laboratory have cracked open the secrets of plant stem cells, mapping key genetic regulators in maize and Arabidopsis. By using single-cell RNA sequencing, they created a gene expression atlas that identifies rare stem cell regulators, links them to crop size and productivity, and offers a new roadmap for breeding resilient, high-yield plants.

A groundbreaking project is piecing together Leonardo da Vinci’s genetic profile by tracing his lineage across 21 generations and comparing DNA from living descendants with remains in a Da Vinci family tomb. If successful, the effort could reveal new insights into Leonardo’s health, creativity, and even help confirm the authenticity of his works.

Mars’ Jezero Crater holds signs of ancient water and strange mineral reactions, some linked with organic compounds. With Perseverance’s samples and AI-refined mineral maps, scientists are closing in on whether Mars once had the chemistry needed for life.

Scientists at Stellenbosch University have uncovered a rare class of plant compounds, flavoalkaloids, in Cannabis leaves for the first time. Using advanced two-dimensional chromatography and mass spectrometry, they identified 79 phenolic compounds across three strains, 25 of which had never before been reported in Cannabis. The surprising discovery highlights the complexity of the plant and its untapped biomedical potential beyond cannabinoids, opening new doors for research and medicine.

A small tissue fold in fly embryos, once thought purposeless, plays a vital role in stabilizing tissues. Researchers show that it absorbs stress during early development, and its position and timing likely shaped its evolutionary emergence.

Scientists have uncovered a surprising new healing mechanism in injured cells called cathartocytosis, in which cells "vomit" out their internal machinery to revert more quickly to a stem cell-like state. While this messy shortcut helps tissues regenerate faster, it also leaves behind debris that can fuel inflammation and even cancer.

Scientists have created glow-in-the-dark succulents that can recharge with sunlight and shine for hours, rivaling small night lights. Unlike costly and complex genetic engineering methods, this breakthrough relies on phosphor particles—similar to those in glow-in-the-dark toys—carefully sized to flow through plant tissues. Surprisingly, succulents turned out to be the best glow carriers, with researchers even building a wall of 56 glowing plants bright enough to read by.

Researchers demonstrated how amino acids could spontaneously attach to RNA under early Earth-like conditions using thioesters, providing a long-sought clue to the origins of protein synthesis. This finding bridges the “RNA world” and “thioester world” theories and suggests how life’s earliest peptides may have formed.

Scientists have discovered that a gene called MUC19, inherited from Denisovans through ancient interbreeding, may have played a vital role in helping Indigenous ancestors adapt as they migrated into the Americas. Found at unusually high frequencies in both modern and ancient populations, the gene likely provided immune advantages against new pathogens. This research highlights how archaic DNA, passed through both Denisovans and Neanderthals, enriched human genetic diversity in ways that still shape us today.

Scientists have developed a breakthrough food supplement that could help save honeybees from devastating declines. By engineering yeast to produce six essential sterols found in pollen, researchers provided bees with a nutritionally complete diet that boosted reproduction up to 15-fold. Unlike commercial substitutes that lack key nutrients, this supplement mimics natural pollen’s sterol profile, giving bees the equivalent of a balanced diet.

Two independent research teams have unveiled near-complete reference genomes of the central bearded dragon, a reptile with the rare ability to change sex depending on both chromosomes and nest temperature. Using next-generation sequencing technologies from China and Australia, the projects uncovered the long-sought genetic basis of sex determination in this lizard.

MSU researchers discovered that microbes begin shaping the brain while still in the womb, influencing neurons in a region critical for stress and social behavior. Their findings suggest modern birth practices that alter the microbiome may have hidden impacts on brain development.

Roughly two-thirds of all atmospheric methane, a potent greenhouse gas, comes from methanogens. Tracking down which methanogens in which environment produce methane with a specific isotope signature is difficult, however. UC Berkeley researchers have for the first time CRISPRed the key enzyme involved in microbial methane production to understand the unique isotopic fingerprints of different environments to better understand Earth's methane budget.

Scientists have engineered a groundbreaking cancer treatment that uses bacteria to smuggle viruses directly into tumors, bypassing the immune system and delivering a powerful one-two punch against cancer cells. The bacteria act like Trojan horses, carrying viral payloads to cancer’s core, where the virus can spread and destroy malignant cells. Built-in safety features ensure the virus can’t multiply outside the tumor, offering a promising pathway for safe, targeted therapy.

By flipping a single genetic switch, researchers made one fruit fly species adopt the gift-giving courtship of another, showing how tiny brain rewiring can drive evolutionary change.

Once on the brink during the last ice age, great white sharks made a remarkable recovery globally, but their DNA reveals a baffling story. Classic migration explanations fail, leaving scientists with a mystery that defies reproductive and evolutionary logic.

Researchers at Scripps have created T7-ORACLE, a powerful new tool that speeds up evolution, allowing scientists to design and improve proteins thousands of times faster than nature. Using engineered bacteria and a modified viral replication system, this method can create new protein versions in days instead of months. In tests, it quickly produced enzymes that could survive extreme doses of antibiotics, showing how it could help develop better medicines, cancer treatments, and other breakthroughs far more quickly than ever before.

Scientists discovered that jewel wasp larvae that undergo a developmental "pause" live longer and age more slowly at the molecular level by nearly 30%. This slowdown is tied to conserved biological pathways, hinting at possible applications for human aging.

Apple snails can fully regrow their eyes, and their genes and eye structures are strikingly similar to humans. Scientists mapped the regeneration process and used CRISPR to identify genes, including pax6, as essential to eye development, raising hopes for future human vision restoration.

A group of Chinese scientists has created powerful new tools that allow them to edit large chunks of DNA with incredible accuracy—and without leaving any trace. Using a mix of advanced protein design, AI, and clever genetic tweaks, they’ve overcome major limitations in older gene editing methods. These tools can flip, remove, or insert massive pieces of genetic code in both plants and animals. To prove it works, they engineered rice that’s resistant to herbicides by flipping a huge section of its DNA—something that was nearly impossible before.

Scientists at UC Merced have engineered artificial cells that can keep perfect time—mimicking the 24-hour biological clocks found in living organisms. By reconstructing circadian machinery inside tiny vesicles, the researchers showed that even simplified synthetic systems can glow with a daily rhythm—if they have enough of the right proteins.

Millipedes, often dismissed as creepy crawlies, may hold the secret to future painkillers and neurological drugs. Researchers at Virginia Tech discovered unique alkaloid compounds in the defensive secretions of a native millipede species. These complex molecules, which cause disorientation in ants, interact with human neuroreceptors linked to pain and cognition. By decoding these natural chemical defenses, scientists could open a new path toward innovative drug therapies, though challenges remain in producing the compounds at scale.

What made ribose the sugar of choice for life's code? Scientists at Scripps Research may have cracked a major part of this mystery. Their experiments show that ribose binds more readily and selectively to phosphate compared to other similar sugars, forming a structure ideal for RNA formation. This discovery hints at how nature might have selected specific molecules long before enzymes or life existed, and could reshape our understanding of life’s chemical origins.

Gene editing may hold the key to rescuing endangered species—not just by preserving them, but by restoring their lost genetic diversity using DNA from museum specimens and related species. Scientists propose a visionary framework that merges biotechnology with traditional conservation, aiming to give struggling populations like Mauritius’ pink pigeon a fighting chance against extinction. From agriculture to de-extinction, these tools are already transforming biology—and now, they could transform the future of biodiversity itself.

What scientists once dismissed as junk DNA may actually be some of the most powerful code in our genome. A new international study reveals that ancient viral DNA buried in our genes plays an active role in controlling how other genes are turned on or off, especially during early human development. These sequences, originally from long-extinct viruses, have evolved to act like tiny genetic switches. Using new analysis tools and large-scale experiments, researchers discovered that certain viral DNA fragments are especially strong at activating genes and may even have helped shape what makes humans different from other primates.

Tourists feeding wild elephants may seem innocent or even compassionate, but a new 18-year study reveals it s a recipe for disaster. Elephants in Sri Lanka and India have learned to beg for snacks sugary treats and human food leading to deadly encounters, injuries, and even the ingestion of plastic. Once wild animals become accustomed to handouts, they lose their natural instincts, grow bolder, and risk both their lives and the safety of humans.