Psychology

A new study suggests that dementia may be driven in part by faulty blood flow in the brain. Researchers found that losing a key lipid causes blood vessels to become overactive, disrupting circulation and starving brain tissue. When the missing molecule was restored, normal blood flow returned. This discovery opens the door to new treatments aimed at fixing vascular problems in dementia.

Alzheimer’s has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain’s energy supply help drive the disease—and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers. The results offer fresh hope that recovery may be possible.

When we watch someone move, get injured, or express emotion, our brain doesn’t just see it—it partially feels it. Researchers found eight body-like maps in the visual cortex that organize what we see in the same way the brain organizes touch. These maps help us instantly understand actions, emotions, and intentions in others. The discovery sheds light on human empathy and opens doors for new brain-based therapies and AI systems that better understand the body.

New research suggests Alzheimer’s may start far earlier than previously thought, driven by a hidden toxic protein in the brain. Scientists found that an experimental drug, NU-9, blocks this early damage in mice and reduces inflammation linked to disease progression. The treatment was given before symptoms appeared, targeting the disease at its earliest stage. Researchers say this approach could reshape how Alzheimer’s is prevented and treated.

Spending a few hours a week helping others may slow the aging of the brain. Researchers found that both formal volunteering and informal acts, like helping neighbors or relatives, were linked to noticeably slower cognitive decline over time. The benefits added up year after year and didn’t require a huge time commitment. Even modest, everyday helping packed a powerful mental payoff.

After injury, the visual system can recover by growing new neural connections rather than replacing lost cells. Researchers found that surviving eye cells formed extra branches that restored communication with the brain. These new pathways worked much like the originals. The repair process, however, was slower or incomplete in females, pointing to important biological differences in recovery.

Consciousness evolved in stages, starting with basic survival responses like pain and alarm, then expanding into focused awareness and self-reflection. These layers help organisms avoid danger, learn from the environment, and coordinate socially. Surprisingly, birds show many of these same traits, from subjective perception to basic self-awareness. This suggests consciousness is far older and more widespread than once believed.

New research shows that your brain’s “true age” can shift dramatically depending on how you live, with optimism, restorative sleep, stress management, and strong social support acting like powerful anti-aging tools. Using advanced MRI-based brain-age estimates, scientists found that people with multiple healthy lifestyle factors had brains up to eight years younger than expected — even among those living with chronic pain.

Natural killer cells act as the immune system’s rapid-response team, but the stress of anxiety and insomnia may be quietly thinning their ranks. A study of young women in Saudi Arabia found that both conditions were linked to significantly fewer NK cells—especially the circulating types responsible for destroying infected or abnormal cells. As anxiety severity increased, NK cell levels dropped even further, suggesting a stress-driven weakening of immune defenses.

Scientists exploring how the brain responds to stress discovered molecular changes that can influence behavior long after an experience ends. They also identified natural resilience systems that help protect certain individuals from harm. These findings are opening the door to treatments that focus on building strength, not just correcting problems. The work is also fueling a broader effort to keep science open, independent, and accessible.

Rats with naturally high stress levels were far more likely to self-administer cannabis when given access. Behavioral testing showed that baseline stress hormones were the strongest predictor of cannabis-seeking behavior. Lower cognitive flexibility and low endocannabinoid levels also contributed to increased use. The results hint at possible early indicators of vulnerability to drug misuse.

Researchers discovered that a tiny structural feature of the enzyme GPX4 helps keep neurons safe. A rare mutation removes this protection, allowing harmful molecules to damage cell membranes and trigger early dementia. Mouse and cell studies showed changes resembling Alzheimer’s. Early tests to slow this damage give scientists new directions to explore.

Deep-brain recordings showed that Mounjaro and Zepbound briefly shut down the craving circuits linked to food noise in a patient with severe obesity. Her obsessive thoughts about food disappeared as the medication quieted the nucleus accumbens, the brain’s reward hub.

Human biology evolved for a world of movement, nature, and short bursts of stress—not the constant pressure of modern life. Industrial environments overstimulate our stress systems and erode both health and reproduction. Evidence ranging from global fertility declines to chronic inflammatory diseases shows the toll of this mismatch. Researchers say cultural and environmental redesign, especially nature-focused planning, is essential.

Scientists uncovered a surprising four-layer structure hidden inside the hippocampal CA1 region, one of the brain’s major centers for memory, navigation, and emotion. Using advanced RNA imaging techniques, the team mapped more than 330,000 genetic signals from tens of thousands of neurons, revealing crisp, shifting bands of cell types that run along the length of the hippocampus. This layered organization may help explain why different parts of CA1 support different behaviors and why certain neurons break down more easily in disorders such as Alzheimer’s disease and epilepsy.

Researchers found that people with anxiety disorders consistently show lower choline levels in key brain regions that regulate thinking and emotions. This biochemical difference may help explain why the brain reacts more intensely to stress in anxiety conditions. Scientists believe nutrition could play a role in restoring balance, though more research is needed. Many Americans already fall short of recommended choline intake, making diet a potential area of interest.

Nitrous oxide may offer quick, short-term relief for people with major depression, especially those who haven’t responded to standard medications. The meta-analysis found rapid improvements after a single dose and more sustained benefits after repeated treatments. Side effects were generally mild and brief, though researchers stress the need for larger, longer-term studies.

A large study of brain scans shows that our neural wiring evolves through five major stages from birth to late old age. These phases are separated by sudden turning points that mark big shifts in how the brain is organized. The most surprising discovery is that adolescent-style development lasts into our early thirties. The work helps explain changing abilities and risks at different points in life.

MIT scientists found that what we see is strongly influenced by how alert or active we are. Parts of the brain responsible for planning and control send specialized signals that either boost or quiet visual details. These areas seem to balance each other, sharpening important information while dimming distractions. The study shows vision is constantly being shaped by our internal state.

Scientists have uncovered a stepwise system that guides how the brain sorts and stabilizes lasting memories. By tracking brain activity during virtual reality learning tasks, researchers identified molecules that influence how long memories persist. Each molecule operates on a different timescale, forming a coordinated pattern of memory maintenance. The discoveries reshape how scientists understand memory formation.

Princeton researchers found that the brain excels at learning because it reuses modular “cognitive blocks” across many tasks. Monkeys switching between visual categorization challenges revealed that the prefrontal cortex assembles these blocks like Legos to create new behaviors. This flexibility explains why humans learn quickly while AI models often forget old skills. The insights may help build better AI and new clinical treatments for impaired cognitive adaptability.

Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light chain, a marker of neuron injury. Low choline levels appeared closely tied to these changes. The results hint that early metabolic disruptions may quietly influence the brain long before symptoms emerge.

Scientists discovered that lowered brain energy signaling in the hippocampus can lead to both depression- and anxiety-like behaviors in mice. Stress reduced ATP, a molecule important for cell energy and communication. Altering a protein called connexin 43, which helps release ATP, caused similar symptoms even without stress. Restoring this protein improved mood-related behavior.

Scientists found that people who use both cannabis and tobacco show a distinct brain pattern tied to mood and stress regulation. Their scans revealed higher levels of an enzyme that reduces a natural feel-good molecule in the brain. This imbalance may help explain why co-users experience more anxiety and struggle more when quitting.

Researchers have uncovered surprising evidence that anxiety may be controlled not by neurons but by two dueling groups of immune cells inside the brain. These microglia act like biological pedals—one pushing anxiety forward and the other holding it back.

Researchers scanning soccer fans’ brains found that wins trigger bursts of reward activity while losses dampen control signals. The results show how loyalty and rivalry can override logic, turning competition into an emotional storm. The same brain circuits that fuel sports passion may also underlie political or social fanaticism. Early experiences, the study suggests, shape whether these circuits lead to healthy excitement or explosive reactions.

Researchers identified SGK1 as a key chemical connecting childhood trauma to depression and suicidal behavior. High SGK1 levels were found in the brains of suicide victims and in people with genetic variants linked to early adversity. Drugs that block SGK1 could offer a new kind of antidepressant, especially for patients resistant to SSRIs.

Millions struggle with depression and anxiety, often enduring long waits for effective treatment. Scientists in Sweden, Denmark, and Germany are developing a genetic test to predict which medications will actually work. Using polygenic risk scores, they can analyze DNA variations linked to mental health and drug response.

Sertraline (Zoloft) may relieve emotional symptoms of depression and anxiety within two weeks, while physical side effects stabilize later. The research highlights how antidepressants can act on specific symptom networks rather than uniformly across all aspects of depression.

New research shows that the superior colliculus, a primitive brain region, can independently interpret visual information. This challenges long-held beliefs that only the cortex handles such complex computations. The discovery highlights how ancient neural circuits guide attention and perception, shaping how we react to the world around us.

Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older rats. Another experiment revived a silenced memory gene, IGF2, through targeted DNA methylation editing. These findings highlight that aging brains can regain function through precise molecular intervention.

Researchers at MIT’s Picower Institute found that rotating waves of brain activity help restore focus after distractions. In animal tests, these rotations predicted performance: full rotations meant full recovery, while incomplete ones led to errors. The brain needed time to complete the cycle, revealing a biological rhythm of cognitive recovery.

Researchers have discovered a specific set of neurons in the amygdala that can trigger anxiety and social deficits when overactive. By restoring the excitability balance in this brain region, they successfully reversed these symptoms in mice. The results point toward targeted neural therapies for emotional disorders. This finding could reshape how anxiety and depression are treated at the circuit level.

Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They discovered that distinct regions activate for facial versus limb pain, showing the brain’s built-in precision pain control system. The findings could lead to targeted, non-opioid treatments that use cannabinoid mechanisms instead of opioids, offering safer pain relief options.

Cognitive struggles are climbing across the U.S., especially among young and economically disadvantaged adults. Rates of self-reported cognitive disability nearly doubled in people under 40 between 2013 and 2023. Researchers suspect social and economic inequality plays a major role and are urging further study to understand the trend’s causes and long-term impact.

People living in socially and economically disadvantaged neighborhoods may face higher dementia risks, according to new research from Wake Forest University. Scientists found biological signs of Alzheimer’s and vascular brain disease in those from high-burden areas, particularly among Black participants. The results suggest that social and environmental injustices can alter brain structure and function. Improving community conditions could be key to protecting brain health.

People with gum disease may have higher levels of brain white matter damage, a new study finds. Researchers observed that participants with gum disease had significantly more white matter hyperintensities, even after accounting for other risk factors. The findings hint that chronic oral inflammation could subtly impact the brain, especially in older adults. More research is needed, but keeping gums healthy might protect the mind too.

UCL scientists found that human skulls evolved much faster than those of other apes, reflecting the powerful forces driving our brain growth and facial flattening. By comparing 3D models of ape skulls, they showed that humans changed about twice as much as expected. The findings suggest that both cognitive and social factors, not just intelligence, influenced our evolutionary path.

Generalized anxiety disorder affects millions, often trapping sufferers in cycles of fear and isolation that conventional medications barely relieve. At UCSF, neuroscientist Jennifer Mitchell is testing a pharmaceutical form of LSD called MM120, which has shown striking results in reducing symptoms by promoting neuroplasticity and easing rigid thought patterns. In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere.

New research reveals that exercise counteracts the mood-damaging effects of a Western-style diet through specific gut and hormonal mechanisms. Running restored metabolites tied to mental well-being and balanced key hormones like insulin and leptin. However, poor diet limited the brain’s ability to generate new neurons, showing diet still matters for full brain benefits.

Menopause brings profound shifts not just in hormones but in the very structure of the brain. Scientists have found that gray matter in regions tied to memory and thinking can shrink, while white matter may show damage linked to blood flow issues. Yet there’s hope — evidence points to partial recovery and adaptive changes postmenopause.

Feeling in control may be the key to conquering daily stress. Penn State researchers found that people were 62% more likely to resolve everyday hassles on days when they felt greater control. This link grew stronger over time, suggesting we get better at managing stress as we age. Simple actions like setting priorities and reframing challenges can help boost that sense of control and reduce overall stress.

Finasteride, a common hair-loss drug, has long been tied to depression and suicide, but regulators ignored the warnings. Prof. Mayer Brezis’s review exposes global data showing psychiatric harm and a pattern of inaction by Merck and the FDA. Despite its cosmetic use, the drug’s effects on brain chemistry can be devastating. Brezis calls for urgent regulatory reforms and post-marketing studies to protect public health.

People experiencing their first psychotic episode who also have skin conditions such as rashes or itching are at greater risk of depression and suicidal thoughts, according to new research presented at the ECNP meeting. Scientists found that 25% of these patients experienced suicidal ideation, compared with only 7% of those without skin issues. The study suggests that dermatological symptoms could serve as early warning markers for worse psychiatric outcomes.

Different types of depression affect the body in different ways. Atypical, energy-related depression raises the risk of diabetes, while melancholic depression increases the likelihood of heart disease. Scientists say these differences reflect distinct biological pathways and highlight the need for personalized mental and physical health care.

Researchers have identified two compounds, K102 and K110, that could repair the nerve damage from multiple sclerosis. These drugs help regenerate the protective myelin sheath and balance immune responses. Licensed by Cadenza Bio, the discovery represents a leap from lab research to potential clinical therapy. If successful, it could transform how neurodegenerative diseases are treated.

A University of Toronto study found that nearly one in four adults aged 60+ who reported poor well-being were able to regain optimal wellness within three years. The research highlights that physical activity, healthy weight, good sleep, and emotional and social support play crucial roles in recovery. Those with strong psychological wellness at the start were five times more likely to bounce back.

Scientists identified two types of brain cells, neurons and microglia, that are altered in people with depression. Through genomic mapping of post-mortem brain tissue, they found major differences in gene activity affecting mood and inflammation. The findings reinforce that depression has a clear biological foundation and open new doors for treatment development.

Addiction often isn’t about chasing pleasure—it’s about escaping pain. Researchers at Scripps Research have discovered that a tiny brain region called the paraventricular nucleus of the thalamus (PVT) becomes hyperactive when animals learn that alcohol eases the agony of withdrawal. This circuit helps explain why people relapse: their brains learn that alcohol brings relief from stress and anxiety.

Scientists discovered that lifelong social support can slow biological aging. Using DNA-based “epigenetic clocks,” they found that people with richer, more sustained relationships showed younger biological profiles and lower inflammation. The effect wasn’t about single friendships but about consistent connections across decades.

Penn researchers found that psilocybin can calm brain circuits tied to pain and mood, easing both physical suffering and emotional distress in animal studies. The compound works in the anterior cingulate cortex, bypassing injury sites and offering a dual benefit for pain and depression. Unlike opioids, psilocybin is non-addictive and may provide relief lasting weeks.

Scientists confirmed that pianists can alter timbre through touch, using advanced sensors to capture micro-movements that shape sound perception. The discovery bridges art and science, promising applications in music education, neuroscience, and beyond.

Scientists discovered that high-fat junk food disrupts memory circuits in the brain almost immediately. Within just four days, neurons in the hippocampus became overactive, impairing memory. Restoring glucose calmed the neurons, showing that interventions like fasting or dietary shifts can restore brain health. This could help prevent obesity-related dementia and Alzheimer’s.

Boston University researchers found that ordinary moments can gain staying power if they’re connected to significant emotional events. Using studies with hundreds of participants, they showed that the brain prioritizes fragile memories when they overlap with meaningful experiences. This could help explain why we recall certain details surrounding big events and may lead to new ways of boosting learning and treating memory disorders.

New studies reveal that lifestyle changes—such as exercise, healthy eating, and social engagement—can help slow or prevent cognitive decline. Experts say this low-cost, powerful approach could transform dementia care and reduce its crushing toll on families and health systems.

Scientists have uncovered how the brain reroutes its communication pathways depending on whether it’s processing something new or recalling the familiar. By fine-tuning the balance between different inhibitory circuits, the brain flexibly shifts between reactivating stored memories and integrating fresh sensory input. This discovery not only reshapes our understanding of brain rhythms but also opens new doors for exploring how attention, cognition, and even neurological disorders like epilepsy or Alzheimer’s may emerge from disrupted balance.

Researchers from the University of Waterloo discovered that measuring long-term stress through children’s hair samples can reveal early signs of mental health risks in those living with chronic physical illnesses. Children with persistently high cortisol were more likely to struggle with anxiety, depression, and behavioral challenges, while those whose stress markers declined showed fewer problems.

UC Berkeley researchers mapped the brain circuits that control growth hormone during sleep, uncovering a feedback system where sleep fuels hormone release, and the hormone regulates wakefulness. The discovery helps explain links between poor sleep, obesity, diabetes, and cognitive decline, while opening new paths for treating sleep and metabolic disorders.

Scientists at Stanford have found that hyperactivity in the brain’s reticular thalamic nucleus may drive autism-like behaviors. In mouse models, drugs and neuromodulation techniques that suppressed this overactive region reversed symptoms, hinting at new therapeutic pathways that overlap with epilepsy treatments.

Getting a smartphone before age 13 may drastically increase the risk of poor mental health later in life, according to data from more than 100,000 people. Early use is linked to suicidal thoughts, aggression, and detachment, largely driven by social media, cyberbullying, and lost sleep. Researchers urge urgent action to restrict access and protect young minds.