Biological Sciences

Laboratory could improve crop resilience In a discovery three decades in the making, scientists have acquired detailed knowledge about the internal structures and mode of regulation for a specialized protein and are proceeding to develop tools that can capitalize on its ability to help plants combat a wide range of diseases. The work, which exploits a natural process where plant cells die on purpose to help the host plant stay healthy, is expected to have wide applications in the agricultural sector, offering new ways to protect major food crops from a variety of devastating diseases, the scientists said.

To achieve the European Green Deal's goal of 25% organic agriculture by 2030, researchers argue that new genomic techniques (NGTs) should be allowed without pre-market authorization in organic as well as conventional food production. NGTs -- also known as gene editing --- are classified under the umbrella of GMOs, but they involve more subtle genetic tweaks.

Long considered a disease brought to the Americas by European colonizers, leprosy may actually have a much older history on the American continent. Scientists reveal that a recently identified second species of bacteria responsible for leprosy, Mycobacterium lepromatosis, has been infecting humans in the Americas for at least 1,000 years, several centuries before the Europeans arrived.

Scientists found out how naturally unstable filaments decide whether to grow or to shorten.

A new study reveals that the aerobic nitrogen cycle in the ocean may have occurred about 100 million years before oxygen began to significantly accumulate in the atmosphere, based on nitrogen isotope analysis from ancient South African rock cores. These findings not only refine the timeline of Earth's oxygenation but also highlight a critical evolutionary shift, where life began adapting to oxygen-rich conditions -- paving the way for the emergence of complex, multicellular organisms like humans.

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study.

New techniques used to analyze soft tissue in dinosaur fossils may hold the key to new cancer discoveries. Researchers have analyzed dinosaur fossils using advanced paleoproteomic techniques, a method that holds promise for uncovering molecular data from ancient specimens.

A professor of crop sciences and of plant biology describes research efforts to 'future-proof' the crops that are essential to feeding a hungry world in a changing climate. Long, who has spent decades studying the process of photosynthesis and finding ways to improve it, provides an overview of key scientific findings that offer a ray of hope.

Scientists have pioneered a new way to breed climate-resilient crops faster by combining plant genebank data with climate and DNA analysis. The method, tested on sorghum, could speed up global efforts to secure food supplies in a changing climate.

Researchers have identified a monoacylglycerol acyltransferase-coding gene named bishu-1. It is involved in the thermal responsiveness of cool temperature-sensing neurons by regulating ionotropic receptor expression, thereby maintaining the cool temperature avoidance behaviors in Drosophila larvae.

Coffee can help you stay awake. But what does caffeine actually do to your brain once you're asleep? Using AI, a team of researchers has an answer: it affects the brain's 'criticality'.

New HIV research shows that small changes in the virus affect how quickly or slowly it replicates and how easily it can reawaken in the body. These insights bring researchers closer to finding ways to flush out the dormant virus and eliminate it for good.

Whether you are lucky enough to have a cat companion or must merely live this experience vicariously through cat videos, Felis catus is a familiar and comforting presence in our daily lives. Unlike most other feline species, cats exhibit sociality, can live in groups, and communicate both with other cats and humans, which is why they have been humans' trusted accomplices for millennia. Despite this intimacy, there is still much that we don't know about our feline friends.

Researchers have identified a previously unknown species of unicellular organism in seawater collected near Hachijojima Island. The newly discovered species, named Viscidocauda repens, belongs to the protist group Endomyxa and is notable for possessing a persistent flagellum -- marking the first recorded instance of such a flagellate within this group.

Scientists analyzed almost 200 cannabis genomes to create the most comprehensive, high-quality, detailed genetic atlas of the plant to date. The atlas reveals unprecedented diversity and complexity within the species, sets the stage for advances in cannabis-based agriculture, medicine, and industry, and builds on a 10,000-year long relationship between humans and cannabis, showing that cannabis can be as important as other crops like corn or wheat.

A study finds small-scale tree cover in Costa Rica boosts biodiversity while limiting dangerous mosquito species.

A new study integrated mathematical modeling with advanced imaging to discover that the physical shape of the fruit fly egg chamber, combined with chemical signals, significantly influences how cells move. Cell migration is critical in wound healing, immune responses, and cancer metastasis, so the work has potential to advance a range of medical treatments.

A new concept of kinetic modules in biochemical networks could revolutionize the understanding of how these networks function. Scientists succeeded in linking the structure and dynamics of biochemical networks via kinetic modules, thus clarifying a systems biology question that has been open for longtime.

Scientists created dye-based molecules that self-assemble into ring-shaped structures, mimicking nature's light-harvesting systems. These stacked rings allow electrons and energy to circulate freely, demonstrating a phenomenon called toroidal conjugation. The work could inspire new materials for solar energy, optoelectronics and next-generation electronic devices.

Researchers compared the whole genome sequence of two genetically distinct lineages of bed bug, and their findings indicate bed bugs may well be the first true urban pest.

Obesity is a global health problem that affects many people. In recent years, very promising anti-obesity drugs have been developed. Despite these successes, there are patients who do not respond to these drugs or suffer from side effects. Therefore, there is still an unmet need for therapies. Researchers have now discovered a small group of nerve cells in the hypothalamus of mouse brains that influence eating behavior and weight gain. This discovery could pave the way for the development of new targeted anti-obesity drugs.

A new species of velvet worm, Peripatopsis barnardi, represents the first ever species from the arid Karoo, which indicates that the area was likely historically more forested than at present. In the Cape Fold Mountains, we now know that every mountain peak has an endemic species. This suggests that in unsampled areas there are likely to be additional novel diversity, waiting to be found.

Parasitic worms that infect humans are not interbreeding with those that infect cattle as previously thought. This is good news for when it comes to controlling schistosomiasis, a disease caused by these worms that affects more than 200 million people globally.

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis. However, it takes considerable effort to produce it in immortalized hamster cells. This process is also costly. It would be far more cost-effective to produce it with undemanding yeast cells.

Palaeontologists have analyzed the most complete stegosaurian skull ever found in Europe and rewritten the evolutionary history of this iconic group of dinosaurs.

Scientists have developed a unified theory for mathematical parameters known as gauge freedoms. Their new formulas will allow researchers to interpret research results much faster and with greater confidence. The development could prove fundamental for future efforts in agriculture, drug discovery, and beyond.

Chemists have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth -- a key process in the origin of life.

Researchers find high-fat diets set off metabolic dysfunction in cells, leading to weight gain, but these effects can be reversed by treatment with an antioxidant.

A team identified herpes virus saimiri, which infects the T cells of squirrel monkeys, as a source of proteins that activate pathways in T cells that are needed to promote T cell survival.

In a major leap forward for genetic and biomedical research, scientists have developed a powerful new artificial intelligence tool that can predict the 3D shape of chromosomes inside individual cells -- helping researchers gain a new view of how our genes work.

The aging of the innermost cell layer of blood vessels leads to cardiovascular diseases. Researchers have now shown for the first time that intestinal bacteria and their metabolites contribute directly to vascular aging. As people age, the bacterial composition in their gut changes, resulting in fewer 'rejuvenating' and more harmful substances in the body.

A new study finds that chronic cannabis use -- whether it's smoked or consumed in edible form -- is associated with significant cardiovascular risks.

As rising global temperatures alter ecosystems worldwide, animal species usually have two choices: adapt to changing local conditions or flee to a cooler clime. Ecologists have long assumed that the world's bird species were best equipped to respond to the pressures of climate change simply because they have the option of flying to higher altitudes or towards global poles. But a new study finds that few bird species are able to escape the realities of a warming world.

A new study reveals the biological secret to the Zika virus's infectious success: Zika uses host cells' own 'self-care' system of clearing away useless molecules to suppress the host proteins that the virus has employed to get into those cells in the first place.

Researchers found that digestion in hawks and owls can alter the results of isotopic analysis in pellets and droppings.

Scientists, who have spent more than a decade examining the impact of artificial light at night on the world's coasts and oceans, have shown that more than one-fifth of the global ocean -- an area spanning more than 75 million sq km -- has been the subject of ocean darkening over the past two decades. Ocean darkening occurs when changes in the optical properties of the ocean reduce the depth of its photic zones, home to 90% of all marine life and places where sunlight and moonlight drive ecological interactions.

Alterations to the diet of pests could impact how quickly they can adapt to biopesticides.

Scientists have discovered cells in the skin of Atlantic salmon that offer new insights into how wounds heal, tissues regenerate, and cellular transitions support long-term skin health.

Humans were making tools from whale bones as far back as 20,000 years ago, according to a new study. This discovery broadens our understanding of early human use of whale remains and offers valuable insight into the marine ecology of the time.

Flowers grow stems, leaves and petals in a perfect pattern again and again. A new study shows that even in this precise, patterned formation in plants, gene activity inside individual cells is far more chaotic than it appears.

A gene that regulates the development of roots in vascular plants is also involved in the organ development of liverworts -- land plants so old they don't even have proper roots. The discovery highlights the fundamental evolutionary dynamic of co-opting, evolving a mechanism first and adopting it for a different purpose later.

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden rules that should be considered to build a functional enzyme.

Daylight can boost the immune system's ability to fight infections.

The molecular pathways involved in antiviral defenses and counter-defenses in host-pathogen systems remain unclear. Researchers have used Neurospora crassa as a model organism to explore how RNA editing influences fungal antiviral responses. They identified two neighboring genes -- an RNA-editing enzyme (old) and a transcription factor (zao) -- that regulate virus-induced gene expression. Their findings show how the old-zao module controls both asymptomatic and symptomatic infections, providing new insight into conserved antiviral mechanisms in fungi.

Cold-adapted animals started to evolve 2.6 million years ago when the permanent ice at the poles became more prevalent. There followed a time when the continental ice sheets expanded and contracted and around 700,000 years ago the cold periods doubled in length. This is when many of the current cold-adapted species, as well as extinct ones like mammoths, evolved.

A new study shows that monitoring and managing select bird species can provide benefits for other species within specific regions.

Research reveals that for C. elegans worms, the presence of dead members of their species has profound behavioral and physiological effects, leading them to more quickly reproduce and shortening their lifespans.

New research shows how rapidly proliferating turf algae are waging 'chemical warfare' to inhibit the recovery of kelp forests along Maine's warming coast.

Proteins catalyze life by changing shape when they interact with other molecules. The result is a muscle twitching, the perception of light, or a bit of energy extracted from food. The ability to engineer shapeshifting proteins opens new avenues for medicine, agriculture, and beyond.

Researchers have analyzed ancient DNA from Borrelia recurrentis, a type of bacteria that causes relapsing fever, pinpointing when it evolved to spread through lice rather than ticks, and how it gained and lost genes in the process.

A new study proves that a type of genetic element called 'introners' are the mechanism by which many introns spread within and between species, also providing evidence of eight instances in which introners have transferred between unrelated species in a process called 'horizontal gene transfer,' the first proven examples of this phenomenon.

New research examining 11,700 years of bowhead whale persistence throughout the Arctic projects that sea ice loss due to climate change will cause their habitat to severely contract by up to 75 per cent.

Chemists have developed an efficient skeletal editing method for frequently used heteroaromatic structures. The technique could serve as a means to chemically modify biologically active compounds.

The bacteria that cause tuberculosis (TB) may have an 'on-off switch' that lets them pause and restart growth, according to a new study. The research helps explain why TB is so hard to treat with antibiotics and could pave the way for better drugs.

An analysis of 900 species over a 20-year period showed that biodiversity enhances ecosystem stability and helps safeguard natural communities in a changing environment.

Researchers uncover a notorious cholera strain that contains sophisticated immune systems to fend off viruses, which potentially helped it to fuel a devastating epidemic across Latin America.

Planting flower strips in a field with at least two species can increase the number of natural enemies of pests by 70 percent. The more flower species, the better the effect, according to a new meta-analysis.

Scientists have developed a new surgical technique for implanting multiple tissue grafts in the eye's retina. The findings in animals may help advance treatment options for dry age-related macular degeneration (AMD), which is a leading cause of vision loss among older Americans.

Clownfish have been shown to shrink in order to survive heat stress and avoid social conflict, research reveals.

New research has shed light on how plants precisely control their growth and development, revealing that seemingly similar molecular components fulfill surprisingly different jobs.