Medical and Health Sciences

Researchers have discovered a previously unknown enzyme that plays a crucial role in fat production. By blocking it, they stopped weight gain, reduced liver damage, and lowered harmful cholesterol levels in animal studies. The finding opens the door to a new kind of medication that could tackle obesity, fatty liver disease, and cardiovascular disease all at once.

Colorectal cancer has long baffled scientists because, unlike most tumors, patients often do better when their cancers are packed with immune-suppressing regulatory T cells. New research finally explains why. Scientists discovered that these T cells aren’t all the same: one subtype actually helps keep tumors in check, while another shields cancer from immune attack. The balance between these “good” and “bad” cells can determine whether a tumor grows or shrinks.

Scientists at Keck Medicine of USC are testing an experimental stem cell therapy that aims to restore the brain’s ability to produce dopamine, the chemical whose loss drives Parkinson’s disease. The early-stage clinical trial involves implanting lab-grown dopamine-producing cells directly into a key movement-control region of the brain, with the hope of slowing disease progression and improving motor function.

New research using rhesus monkeys suggests that the brain’s relationship with alcohol may begin forming long before a person ever takes a drink. Scientists found that exposure to alcohol before birth reshaped the brain’s dopamine system, a key player in motivation and reward, and those changes were linked to faster drinking later in adulthood.

Scientists in Australia have uncovered a clever new way to fight some of the most dangerous drug-resistant bacteria by targeting a sugar that exists only on bacterial cells. By designing antibodies that recognize this unique sugar, researchers were able to guide the immune system to attack and eliminate deadly infections that normally shrug off antibiotics.

A new imaging breakthrough combines ultrasound and light-based techniques to generate vivid 3D images that show both tissue structure and blood vessel activity. Developed by researchers at Caltech and USC, the system delivers detailed results quickly and without radiation or contrast dyes. It has already been used to image multiple parts of the human body. The approach could significantly improve cancer detection, nerve-damage monitoring, and brain imaging.

Researchers have figured out how psoriasis can quietly turn into joint disease for some patients. Immune cells formed in inflamed skin can travel through the blood and reach the joints, where they sometimes trigger inflammation. The key difference lies in the joint’s ability to keep those cells in check. This insight could help doctors identify warning signs early and prevent lasting joint damage.

People who switch to a fully unprocessed diet don’t just eat differently—they eat smarter. Research from the University of Bristol shows that when people avoid ultra-processed foods, they naturally pile their plates with fruits and vegetables, eating over 50% more food by weight while still consuming hundreds fewer calories each day. This happens because whole foods trigger a kind of built-in “nutritional intelligence,” nudging people toward nutrient-rich, lower-calorie options.

Kidney disease often creeps in silently, and many patients aren’t diagnosed until major damage is already done. New research shows that even “normal” kidney test results can signal danger if they’re unusually low for someone’s age. By mapping kidney function across the population, scientists revealed who’s quietly at higher risk. A new online tool could help doctors catch these warning signs years earlier.

Researchers have created the first complete map showing how hundreds of mutations in a key cancer gene affect tumor growth. By testing every possible mutation in a critical hotspot, they found that some changes barely boost cancer signals, while others supercharge them. When matched against real patient data, the map accurately predicted cancer behavior across tissues.

Advanced care provided by air ambulance teams was linked to higher survival rates in major trauma patients. Researchers found that more people survived than predicted by standard models, including many with severe injuries and low chances of survival. Younger patients and those more responsive at first assessment benefited most. Outcomes for traumatic cardiac arrest also improved steadily over the study period.

At just two months old, babies are already organizing the world in their minds. Brain scans revealed distinct patterns as infants looked at pictures of animals, toys, and everyday objects, showing early category recognition. Scientists used AI to help decode these patterns, offering a rare glimpse into infant thinking. The results suggest babies begin learning and understanding far sooner than expected.

As bird flu continues to circulate in animals and spill over into humans, researchers are racing to stop it before it adapts to spread widely between people. A new nasal spray vaccine showed strong protection against H5N1 in animal tests, outperforming traditional flu shots. Because it targets the nose and lungs, it may prevent infection at the earliest stage.

Popular weight-loss drugs like Ozempic and Wegovy can dramatically curb appetite, but experts warn many users are flying blind when it comes to nutrition. New research suggests people taking these medications may not be getting enough guidance on protein, vitamins, and overall diet quality, increasing the risk of muscle loss and nutrient deficiencies.

A massive Swedish study tracking nearly 28,000 people for 25 years found an unexpected link between full-fat dairy and brain health. Among adults without a genetic risk for Alzheimer’s, eating more full-fat cheese was associated with a noticeably lower risk of developing the disease, while higher cream intake was tied to reduced dementia risk overall. The findings challenge decades of low-fat dietary advice but come with important caveats.

Scientists still don’t know how the brain turns physical activity into thoughts, feelings, and awareness—but a powerful new tool may help crack the mystery. Researchers at MIT are exploring transcranial focused ultrasound, a noninvasive technology that can precisely stimulate deep regions of the brain that were previously off-limits. In a new “roadmap” paper, they explain how this method could finally let scientists test cause-and-effect in consciousness research, not just observe correlations.

Scientists are digging into why heart disease risk in type 2 diabetes differs between men and women—and sex hormones may be part of the story. In a large Johns Hopkins study, men with higher testosterone had lower heart disease risk, while rising estradiol levels were linked to higher risk. These hormone effects were not seen in women. The results point toward more personalized approaches to heart disease prevention in diabetes.

Sound machines may not be the sleep saviors many believe. Researchers found that pink noise significantly reduced REM sleep, while simple earplugs did a better job protecting deep, restorative sleep from traffic noise. When pink noise was combined with outside noise, sleep quality dropped even further. The results suggest that popular “sleep sounds” could be doing more harm than good—particularly for kids.

Plants make chemical weapons to protect themselves, and many of these compounds have become vital to human medicine. Researchers found that one powerful plant chemical is produced using a gene that looks surprisingly bacterial. This suggests plants reuse microbial tools to invent new chemistry. The insight could help scientists discover new drugs and produce them more sustainably.

As we age, our cells don’t just wear down—they reorganize. Researchers found that cells actively remodel a key structure called the endoplasmic reticulum, reducing protein-producing regions while preserving fat-related ones. This process, driven by ER-phagy, is tied to lifespan and healthy aging. Because these changes happen early, they could help trigger later disease—or offer a chance to stop it.

A new brain imaging study reveals that remembering facts and recalling life events activate nearly identical brain networks. Researchers expected clear differences but instead found strong overlap across memory types. The finding challenges decades of memory research. It may also help scientists better understand conditions like Alzheimer’s and dementia.

Chronic stress can damage the gut’s protective lining, triggering inflammation that may worsen depression. New research shows that stress lowers levels of a protein called Reelin, which plays a key role in both gut repair and brain health. Remarkably, a single injection restored Reelin levels and produced antidepressant-like effects in preclinical models. The findings hint at a future treatment that targets depression through the gut–brain connection.

MMS has long been promoted as a miracle cure, but new research shows it’s essentially a toxic disinfectant. While it can kill bacteria, it only works at levels that also damage human cells and beneficial gut microbes. Scientists warn that homemade MMS mixtures are especially dangerous due to wildly inconsistent dosing. The study calls MMS a clear case where the risks are high—and the benefits are effectively zero.

Researchers studying nearly 2 million older adults found that cerebral amyloid angiopathy sharply raises the risk of developing dementia. Within five years, people with the condition were far more likely to be diagnosed than those without it. The increased risk was present even without a history of stroke. Experts say this makes early screening for memory and thinking changes especially important.

When the brain rests, it usually replays recent experiences to strengthen memory. Scientists found that in Alzheimer’s-like mice, this replay still occurs — but the signals are jumbled and poorly coordinated. As a result, memory-supporting brain cells lose their stability, and the animals struggle to remember where they’ve been.

Middle age is becoming a tougher chapter for many Americans, especially those born in the 1960s and early 1970s. Compared with earlier generations, they report more loneliness and depression, along with weaker physical strength and declining memory. These troubling trends stand out internationally, as similar declines are largely absent in other wealthy nations, particularly in Nordic Europe, where midlife well-being has improved.

Scientists warn that rapid advances in AI and neurotechnology are outpacing our understanding of consciousness, creating serious ethical risks. New research argues that developing scientific tests for awareness could transform medicine, animal welfare, law, and AI development. But identifying consciousness in machines, brain organoids, or patients could also force society to rethink responsibility, rights, and moral boundaries. The question of what it means to be conscious has never been more urgent—or more unsettling.

Researchers found that small doses of an antibiotic can coax gut bacteria into producing a life-extending compound. In worms, this led to longer lifespans, while mice showed healthier cholesterol and insulin changes. Because the drug stays in the gut, it avoids toxic side effects. The study points to a new way of promoting health by targeting microbes rather than the body itself.

Researchers in Bangladesh have identified a bat-borne virus, Pteropine orthoreovirus, in patients who were initially suspected of having Nipah virus but tested negative. All had recently consumed raw date-palm sap, a known pathway for bat-related infections. Genetic analysis confirmed live virus in several samples, pointing to active human infection. The finding raises concerns that dangerous bat viruses may be circulating undetected alongside Nipah.

Statins are a cornerstone of heart health, but muscle pain and weakness cause many patients to quit taking them. Scientists have now identified the precise molecular trigger behind these side effects. They found that statins jam open a critical muscle protein, causing a toxic calcium leak. The discovery could lead to safer statins that keep their life-saving benefits without the muscle damage.

Lowering salt in everyday foods could quietly save lives. Researchers found that modest sodium reductions in bread, packaged foods, and takeout meals could significantly reduce heart disease and stroke rates in France and the U.K. The key advantage is that people would not need to alter their eating habits at all. Small changes to the food supply could deliver large, long-term health benefits.

People who naturally stay up late may be putting their hearts under added strain as they age. A large study tracking more than 300,000 adults found that middle-aged and older night owls had poorer overall heart health and a higher risk of heart attack and stroke than those who were active earlier in the day, with the effect especially pronounced in women. Much of this elevated risk appeared to stem from lifestyle factors common among evening types, including smoking and inadequate sleep.

Men start developing heart disease earlier than women, with risks rising faster beginning around age 35, according to long-term research. The difference is driven mainly by coronary heart disease, not stroke or heart failure. Traditional risk factors explain only part of the gap. The findings suggest earlier screening could help catch problems before serious damage occurs.

A new drug developed by Australian researchers has shown promising results in reducing sepsis in a Phase II clinical trial involving 180 patients. The carbohydrate-based treatment works by calming a dangerous immune reaction that can cause organ failure. With no specific anti-sepsis therapy currently available, the findings mark a major step forward. Researchers now aim to move into Phase III trials.

Researchers have discovered how pancreatic cancer reprograms its surroundings to spread quickly and stealthily. By using a protein called periostin, the tumor remodels nearby tissue and invades nerves, which helps cancer cells travel and form metastases. This process also creates a tough, fibrous barrier that makes treatments less effective. Targeting periostin could help stop this invasion before it starts.

A fast-aging fish is giving scientists a rare, accelerated look at how kidneys grow old—and how a common drug may slow that process down. Researchers found that SGLT2 inhibitors, widely used to treat diabetes and heart disease, preserved kidney structure, blood vessels, and energy production as the fish aged, while also calming inflammation. The results help explain why these drugs protect kidneys and hearts so reliably in people, even beyond blood sugar control.

A new imaging technology called fast-RSOM lets researchers see the smallest blood vessels in the body without invasive procedures. It can detect early dysfunction in these vessels — a quiet warning sign of future heart disease — long before symptoms appear. Unlike traditional risk estimates, it measures real changes happening in the body. The portable system could one day be used in routine checkups to catch heart risks earlier.

Two decades after a breast cancer vaccine trial, every participant is still alive—an astonishing result for metastatic disease. Scientists found their immune systems retained long-lasting memory cells primed to recognize cancer. By enhancing a key immune signal called CD27, researchers dramatically improved tumor elimination in lab studies. The findings suggest cancer vaccines may have been missing a crucial ingredient all along.

Scientists at Mount Sinai have unveiled a bold new way to fight metastatic cancer by turning the tumor’s own defenses against it. Instead of attacking cancer cells head-on, the experimental immunotherapy targets macrophages—immune cells that tumors hijack to shield themselves from attack. By eliminating or reprogramming these “bodyguards,” the treatment cracks open the tumor’s protective barrier and allows the immune system to flood in and destroy the cancer.

Collagen pills sound like a shortcut to younger skin, but solid evidence doesn’t back them up. Higher-quality studies show little benefit, and your body doesn’t absorb collagen in the way ads suggest. Some supplements may even pose safety concerns and lack proper testing. Experts recommend focusing on proven habits like sunscreen, retinoids, and a nutrient-rich diet instead.

An experimental drug once known for helping control type 2 diabetes may also fight heart disease. Researchers found IC7Fc lowered cholesterol, blood fats, and artery-clogging plaques while calming inflammation linked to heart attacks and strokes. Notably, these benefits appeared even without weight loss, suggesting the drug could help lean people at risk of heart disease.

Scientists in Sweden and Norway have uncovered a promising way to spot Parkinson’s disease years—possibly decades—before its most damaging symptoms appear. By detecting subtle biological signals in the blood tied to how cells handle stress and repair DNA, the team identified a brief early window when Parkinson’s quietly leaves a measurable fingerprint.

Helping care for grandchildren may offer an unexpected boost to brain health later in life. Researchers found that grandparents who provided childcare scored higher on memory and verbal skills than those who did not. The effect did not depend on how often they helped or the type of care they provided. Being involved as a caregiver itself appeared to matter most.

Drinking heavily over many years is linked to a higher risk of colorectal cancer, especially rectal cancer, according to new research tracking U.S. adults for two decades. People who drank heavily throughout adulthood faced sharply higher risks than light drinkers. Former drinkers did not show increased cancer risk and had fewer precancerous tumors. The results suggest that quitting alcohol may help lower long-term cancer risk.

Scientists at KAIST have found a way to turn a tumor’s own immune cells into powerful cancer fighters—right inside the body. Tumors are packed with macrophages, immune cells that should attack cancer but are usually silenced by the tumor environment. By injecting a specially designed drug directly into tumors, researchers were able to “reprogram” these dormant cells to recognize and destroy cancer.

Researchers have developed smart nanoparticles that can seek out and destroy disease-causing proteins the body can’t normally eliminate. Unlike traditional drugs, these particles can reach hard-to-access tissues, including the brain, and precisely target problem proteins without widespread side effects. Early results show promise against major cancer drivers, and the platform is designed to be easily adapted to many diseases. The work could reshape the future of precision medicine.

Cancer immunotherapy has been a game-changer, but many tumors still find ways to slip past the immune system. New research reveals a hidden trick: cancer cells can package the immune-blocking protein PD-L1 into tiny particles that circulate through the body and weaken immunotherapy’s impact. Scientists in Japan discovered that a little-known protein, UBL3, controls this process—and surprisingly, common cholesterol-lowering drugs called statins can shut it down.

A massive international study of more than 3,100 long COVID patients uncovered a striking divide in how brain-related symptoms are reported around the world. In the U.S., the vast majority of non-hospitalized patients described brain fog, depression, and anxiety, while far fewer patients in countries like India and Nigeria reported the same issues. The difference doesn’t appear to be about the virus itself, but about culture, stigma, and access to mental health care.

Ozempic, Mounjaro, and Zepbound can drive impressive weight loss, but stopping them is often followed by rapid weight regain. Researchers found that people regain weight faster after quitting these drugs than after diet and exercise alone. Improvements in heart health and diabetes risk also tend to reverse within a few years. The results suggest long-term success may require more than medication alone.

Scientists in South Korea have discovered that one of the most common malignant brain tumors in young adults may begin years before a tumor can be seen. IDH-mutant glioma, long treated by removing visible tumor tissue, actually starts when normal-looking brain cells quietly acquire a cancer-linked mutation and spread through the brain’s cortex. Using advanced genetic mapping and animal models, researchers traced the cancer’s true origin to glial progenitor cells that appear healthy at first.

Where your body stores fat may matter just as much as how much you carry—especially for your brain. Using advanced MRI scans and data from nearly 26,000 people, researchers identified two surprising fat patterns tied to faster brain aging, cognitive decline, and higher neurological disease risk. One involves unusually high fat buildup in the pancreas, even without much liver fat, while the other—often called “skinny fat”—affects people who don’t appear severely obese but carry excess fat relative to muscle.

Drinking tea, particularly green tea, is linked to better heart health, improved metabolism, and lower risks of chronic diseases like diabetes and cancer. It may also help protect the brain and preserve muscle strength as people age. However, processed teas—such as bottled and bubble varieties—often contain sugars and additives that may cancel out these benefits. Moderation and choosing freshly brewed tea appear key.

AI may learn better when it’s allowed to talk to itself. Researchers showed that internal “mumbling,” combined with short-term memory, helps AI adapt to new tasks, switch goals, and handle complex challenges more easily. This approach boosts learning efficiency while using far less training data. It could pave the way for more flexible, human-like AI systems.

A sweeping scientific review highlights wild blueberries as a standout food for cardiometabolic health. The strongest evidence shows improvements in blood vessel function, with encouraging signs for blood pressure, cholesterol, blood sugar, gut health, and cognition. Researchers suggest these benefits may kick in within hours—or build over weeks—thanks to the berries’ unique mix of polyphenols and fiber.

A common parasite long thought to lie dormant is actually much more active and complex. Researchers found that Toxoplasma gondii cysts contain multiple parasite subtypes, not just one sleeping form. Some are primed to reactivate and cause disease, which helps explain why infections are so hard to treat. The discovery could reshape efforts to develop drugs that finally eliminate the parasite for good.

Researchers have discovered a biological switch that explains why movement keeps bones strong. The protein senses physical activity and pushes bone marrow stem cells to build bone instead of storing fat, slowing age-related bone loss. By targeting this “exercise sensor,” scientists believe they could create drugs that mimic exercise at the molecular level. The approach could protect fragile bones in people who are unable to stay active.

Asthma may not be driven by the molecules scientists have blamed for decades. Researchers have identified “pseudo leukotrienes,” inflammation-triggering compounds formed by uncontrolled free-radical reactions rather than normal enzymes. These molecules were found at much higher levels in people with asthma, closely tracking how severe their symptoms were. The finding hints at a new way to treat asthma by preventing the inflammatory spark instead of blocking its aftermath.

A long-term study found that while a ketogenic diet prevented weight gain, it also triggered major metabolic problems. Mice developed fatty liver disease, abnormal blood fats, and an impaired ability to control blood sugar—especially after reintroducing carbohydrates. Male mice were hit hardest, showing severe liver damage. The results suggest keto’s benefits may come with hidden risks over time.

A large French study tracking more than 100,000 people over a decade has found that higher consumption of certain food preservatives—commonly found in processed foods and drinks—is linked to a modestly higher cancer risk. While many preservatives showed no association, several widely used ones, including potassium sorbate, sulfites, sodium nitrite, and potassium nitrate, were tied to increased risks of overall cancer and specific types such as breast and prostate cancer.

Carbohydrates don’t just fuel the body—they may also influence how the brain ages. A large long-term study found that diets high in fast-acting carbs that rapidly raise blood sugar were linked to a higher risk of dementia. People who ate more low-glycemic foods like fruit, legumes, and whole grains had a noticeably lower risk of Alzheimer’s. The quality of carbs, not just the amount, appears to matter for brain health.