Medical and Health Sciences

Researchers discovered how rabies virus exerts massive control over host cells with very few genes. A key viral protein changes shape and binds RNA, allowing it to infiltrate different cellular systems. This adaptability could explain the power of other deadly viruses, including Nipah and Ebola. The breakthrough may lead to next-generation antivirals or vaccines.

Cockroach infestations don’t just bring creepy crawlers, they fill homes with allergens and bacterial toxins that can trigger asthma and allergies. NC State researchers found that larger infestations meant higher toxin levels, especially from female roaches. When extermination eliminated the pests, both allergens and endotoxins plummeted. The findings highlight how pest control is vital for cleaner, healthier air indoors.

Researchers have, for the first time, estimated how quickly E. coli bacteria can spread between people — and one strain moves as fast as swine flu. Using genomic data from the UK and Norway, scientists modeled bacterial transmission rates and discovered key differences between strains. Their work offers a new way to monitor and control antibiotic-resistant bacteria in both communities and hospitals.

Scientists at Mizzou have identified two small molecules, agmatine and thiamine, that could both reveal and fight glaucoma. Their research shows these compounds are lower in glaucoma patients, suggesting they may serve as early warning markers. Even better, they might help protect retinal cells from damage, potentially slowing or stopping vision loss. The discovery could revolutionize how the disease is detected and treated.

A new compound called CMX410 may change the fight against tuberculosis. It targets a weak point in the bacteria’s defenses, even in drug-resistant forms of the disease. Created using a cutting-edge chemistry method, the drug shows promise for being both powerful and safe. Scientists believe it could lead to shorter, more effective treatments for millions of people.

Walking a few thousand steps daily may help hold off Alzheimer’s for years, a Mass General Brigham study found. Even moderate physical activity slowed both cognitive decline and the buildup of harmful tau proteins in the brain. The researchers say these results show lifestyle changes can meaningfully delay Alzheimer’s symptoms, especially in early stages.

A collaboration between Brazilian and German researchers has led to a sunflower-based meat substitute that’s high in protein and minerals. The new ingredient, made from refined sunflower flour, delivers excellent nutritional value and a mild flavor. Tests showed strong texture and healthy fat content, suggesting great potential for use in the growing plant-based food sector.

Researchers at MIT’s Picower Institute found that rotating waves of brain activity help restore focus after distractions. In animal tests, these rotations predicted performance: full rotations meant full recovery, while incomplete ones led to errors. The brain needed time to complete the cycle, revealing a biological rhythm of cognitive recovery.

Researchers have discovered a specific set of neurons in the amygdala that can trigger anxiety and social deficits when overactive. By restoring the excitability balance in this brain region, they successfully reversed these symptoms in mice. The results point toward targeted neural therapies for emotional disorders. This finding could reshape how anxiety and depression are treated at the circuit level.

Using powerful 7-Tesla brain imaging, researchers mapped how the brainstem manages pain differently across the body. They discovered that distinct regions activate for facial versus limb pain, showing the brain’s built-in precision pain control system. The findings could lead to targeted, non-opioid treatments that use cannabinoid mechanisms instead of opioids, offering safer pain relief options.

Long-term melatonin use for sleep problems may come with unexpected heart dangers. Researchers found that chronic users were almost twice as likely to die and 3.5 times more likely to be hospitalized for heart failure. Though melatonin is widely regarded as harmless, experts now urge caution with extended use.

Researchers at McMaster University have discovered that the eyes may offer a powerful, non-invasive way to assess heart health and biological aging. By analyzing retinal scans alongside genetic and blood data from over 74,000 participants, they found that simpler, less branched eye vessels were linked to higher cardiovascular risk and faster aging.

Researchers found that embodying a digital, childlike version of one’s own face helps unlock vivid childhood memories. This illusion strengthens the connection between bodily self-perception and autobiographical recall. The findings suggest that memory retrieval is not purely mental but deeply linked to how we perceive our own bodies. Such insights could lead to tools for recovering forgotten memories or treating memory loss.

UC San Diego researchers combined artificial intelligence with molecular biology to unravel how immune cells in the gut decide between inflammation and healing, a process gone awry in Crohn’s disease. They discovered that the NOD2 gene’s interaction with a protein called girdin is crucial for maintaining balance. When this connection is lost due to a common mutation, inflammation spirals out of control.

Boston researchers linked nighttime light exposure to greater stress-related brain activity and inflamed arteries, signaling a higher risk of heart disease. The study suggests that artificial light at night disrupts normal stress responses, leading to chronic inflammation. Experts call for reducing unnecessary light in cities and homes to protect cardiovascular health.

Duke-NUS scientists unveiled BrainSTEM, a revolutionary single-cell map that captures the full cellular diversity of the developing human brain. The project’s focus on dopamine neurons provides crucial insight for Parkinson’s treatment. Their findings reveal flaws in current lab-grown models while offering a precise, open-source standard for future research. It’s a leap toward more accurate brain modeling and powerful cell-based therapies.

Scientists uncovered how the amino acid leucine enhances mitochondrial efficiency by preserving crucial proteins that drive energy production. By downregulating the protein SEL1L, leucine prevents unnecessary degradation and strengthens the cell’s power output. The findings link diet directly to mitochondrial health and suggest potential therapeutic applications for energy-related diseases.

Penn State scientists uncovered an ancient bacterial defense where dormant viral DNA helps bacteria fight new viral threats. The enzyme PinQ flips bacterial genes to create protective proteins that block infection. Understanding this mechanism could lead to breakthroughs in antivirals, antibiotic alternatives, and industrial microbiology.

A team of scientists has developed a highly accurate blood test for Chronic Fatigue Syndrome. The test reads tiny DNA patterns that reveal the biological signature of the illness. For millions who’ve faced doubt and misdiagnosis, it’s a breakthrough that finally validates their experience — and may help diagnose long Covid too.

Disrupted sleep patterns in Alzheimer’s disease may be more than a symptom—they could be a driving force. Researchers at Washington University found that the brain’s circadian rhythms are thrown off in key cell types, changing when hundreds of genes turn on and off. This disruption, triggered by amyloid buildup, scrambles normal gene timing in microglia and astrocytes—cells vital for brain maintenance and immune defense.

Scientists have discovered that a “longevity gene” found in people who live beyond 100 can reverse heart aging in models of Progeria, a devastating disease that causes children to age rapidly. By introducing this supercentenarian gene into Progeria-affected cells and mice, researchers restored heart function, reduced tissue damage, and slowed aging symptoms. The discovery opens the door to new therapies inspired by the natural biology of long-lived humans—possibly reshaping how we treat both rare diseases and normal aging.

Cognitive struggles are climbing across the U.S., especially among young and economically disadvantaged adults. Rates of self-reported cognitive disability nearly doubled in people under 40 between 2013 and 2023. Researchers suspect social and economic inequality plays a major role and are urging further study to understand the trend’s causes and long-term impact.

Researchers discovered that altering the body’s natural rhythm can help protect the brain from Alzheimer’s damage. By turning off a circadian protein in mice, they raised NAD+ levels and reduced harmful tau buildup. The findings suggest that adjusting the body’s clock may one day help prevent neurodegeneration.

New research from Australia overturns the old idea that exercise “uses up” heartbeats. It shows that fitter people actually use fewer total heartbeats each day thanks to their lower resting heart rates, even when accounting for workouts. Athletes’ hearts beat around 10% less daily, saving over 11,000 beats per day compared to sedentary people. This efficiency not only signals cardiovascular fitness but also translates to longer life expectancy and lower disease risk.

More screen time among children and teens is linked to higher risks of heart and metabolic problems, particularly when combined with insufficient sleep. Danish researchers discovered a measurable rise in cardiometabolic risk scores and a metabolic “fingerprint” in frequent screen users. Experts say better sleep and balanced daily routines can help offset these effects and safeguard lifelong health.

People living in socially and economically disadvantaged neighborhoods may face higher dementia risks, according to new research from Wake Forest University. Scientists found biological signs of Alzheimer’s and vascular brain disease in those from high-burden areas, particularly among Black participants. The results suggest that social and environmental injustices can alter brain structure and function. Improving community conditions could be key to protecting brain health.

Scientists discovered that a blood molecule called CtBP2 may play a major role in how we age. It helps regulate metabolism and appears to link aging across the entire body. Lower levels are tied to poor health and faster aging, while higher levels are found in longer-living people. The finding could lead to simple blood tests that reveal how healthy or “young” your body really is.

Semaglutide appears to safeguard the heart even when patients lose little weight. In a massive international trial, heart attack and stroke risk dropped by 20% regardless of BMI. The benefit seems tied not just to slimming down but to deeper biological effects on inflammation, blood pressure, and vessel health. Researchers say this could expand who qualifies for the drug.

Researchers in Japan have revealed how some gourds draw pollutants into their fruits. The secret lies in a protein that carries contaminants through the plant sap. By manipulating this protein’s structure, scientists hope to breed crops that resist contamination or serve as natural soil purifiers. This finding bridges food safety and environmental cleanup.

From mini-brains to spider-inspired gloves and wolf apple coatings, scientists are turning eerie-sounding experiments into real innovations that could revolutionize health and sustainability. Lab-grown brain organoids may replace animal testing, spider-silk gloves could create instant wound dressings, wolf apple starch keeps veggies fresh, and researchers even found microplastics lurking in human retinas—offering both wonder and a warning about the modern world.

By electrically stimulating macrophages, scientists at Trinity College Dublin have found a way to calm inflammation and promote faster healing. The process turns these immune cells into tissue-repairing helpers, enhancing regeneration and blood vessel growth. Safe, effective, and based on human cells, this discovery could revolutionize treatments for inflammation and injury recovery.

People with gum disease may have higher levels of brain white matter damage, a new study finds. Researchers observed that participants with gum disease had significantly more white matter hyperintensities, even after accounting for other risk factors. The findings hint that chronic oral inflammation could subtly impact the brain, especially in older adults. More research is needed, but keeping gums healthy might protect the mind too.

UCL scientists found that human skulls evolved much faster than those of other apes, reflecting the powerful forces driving our brain growth and facial flattening. By comparing 3D models of ape skulls, they showed that humans changed about twice as much as expected. The findings suggest that both cognitive and social factors, not just intelligence, influenced our evolutionary path.

Flatworms can rebuild themselves from just a small fragment, and now scientists know why. Their stem cells ignore nearby instructions and respond to long-distance signals from other tissues. This discovery turns old stem cell theories upside down and could lead to new ways to repair or regrow human tissue. It also reveals a hidden complexity in one of nature’s simplest creatures.

Researchers used supramolecular nanoparticles to repair the brain’s vascular system and reverse Alzheimer’s in mice. Instead of carrying drugs, the nanoparticles themselves triggered natural clearance of amyloid-β proteins. This restored blood-brain barrier function and reversed memory loss. The results point to a revolutionary new path for treating neurodegenerative diseases.

Finnish scientists found that eicosapentaenoic acid (EPA) from fish oil impacts each person’s metabolism uniquely. Participants showed strong but short-lived increases in EPA levels, with significant differences in lipid profiles. The results reveal how metabolism shapes individual responses to omega-3 supplements and underscore the need for personalized heart health strategies.

New research reveals that intelligence plays a key role in how well people process speech in noisy environments. The study compared neurotypical and neurodivergent individuals and found that cognitive ability predicted performance across all groups. This challenges the idea that listening struggles are solely due to hearing loss, emphasizing the brain’s role in decoding complex soundscapes.

A new McGill-led study reveals that digital brain exercises can rejuvenate aging brain systems responsible for learning and memory. Older adults using BrainHQ for 10 weeks showed restored cholinergic function — effectively turning back the brain’s clock by a decade. Scans confirmed measurable biochemical changes, offering a hopeful new approach for dementia prevention.

A team of scientists discovered a hidden antibiotic 100 times stronger than existing drugs against deadly superbugs like MRSA. The molecule had been overlooked for decades in a familiar bacterium. It shows no signs of resistance so far, offering hope in the fight against drug-resistant infections and paving the way for new approaches to antibiotic discovery.

An international team of researchers led by scientists from the Max Planck Institute for Evolutionary Anthropology in Leipzig, working with 15 collaborators around the world, has conducted the most comprehensive study yet of lifespan differences between the sexes in mammals and birds. Their findings shed new light on one of biology’s enduring mysteries: why males and females age differently.

ETH Zurich scientists have created “MetaGraph,” a revolutionary DNA search engine that functions like Google for genetic data. By compressing global genomic datasets by a factor of 300, it allows researchers to search trillions of DNA and RNA sequences in seconds instead of downloading massive data files. The tool could transform biomedical research and pandemic response.

A new study offers reassurance about the safety of certain processed fats found in everyday foods. Interesterified fats made from palm or plant oils didn’t raise cholesterol or cause metabolic harm in healthy adults. The research challenges the idea that all processed fats are dangerous and shows that food technology can replace trans fats safely.

Researchers found that COVID-19 mRNA vaccines significantly increased survival in lung and skin cancer patients undergoing immunotherapy. The vaccine appears to prime the immune system in a powerful, nonspecific way, enhancing cancer treatment outcomes. If confirmed, the discovery could lead to a universal cancer vaccine and transform oncology care.

New research reveals that walking in longer, uninterrupted bouts of 10–15 minutes significantly lowers cardiovascular disease risk—by up to two-thirds compared to shorter strolls. Scientists from the University of Sydney and Universidad Europea found that even people who walk less than 8,000 steps daily can see major heart health benefits simply by changing how they walk. Those who took their steps in one or two continuous sessions had lower rates of heart attacks, strokes, and death.

Researchers at UC Davis discovered that adding a banana to your smoothie may drastically reduce the absorption of flavanols — powerful compounds linked to heart and brain health. The culprit is polyphenol oxidase (PPO), an enzyme abundant in bananas that interferes with flavanol availability. In experiments, banana-based smoothies cut flavanol absorption by 84% compared to berry-based ones.

Generalized anxiety disorder affects millions, often trapping sufferers in cycles of fear and isolation that conventional medications barely relieve. At UCSF, neuroscientist Jennifer Mitchell is testing a pharmaceutical form of LSD called MM120, which has shown striking results in reducing symptoms by promoting neuroplasticity and easing rigid thought patterns. In clinical trials, a single dose significantly outperformed standard treatments, offering hope to those who have found little relief elsewhere.

Groundbreaking research published in The Lancet suggests that most people who believe they’re sensitive to gluten are actually reacting to other factors like FODMAPs or brain-gut dynamics. The study challenges the idea that gluten itself is the culprit behind symptoms in non-coeliac gluten sensitivity. Experts call for better diagnostic tools, more personalized treatment, and an end to unnecessary gluten avoidance.

King’s College London researchers discovered that parts of our DNA once thought to be “junk” can actually help destroy cancer cells. In some blood cancers, damaged genes trigger chaos in these DNA segments, leaving cancer cells vulnerable. When scientists used existing drugs to block the cells’ repair systems, the cells collapsed. This finding could open the door to new treatments for hard-to-treat cancers.

People with both cavities and gum disease were found to have an 86% higher stroke risk than those with healthy mouths. The study followed thousands of adults for two decades, linking poor oral health with major cardiovascular events. Regular dental checkups dramatically reduced these risks, hinting that simple oral care could play a vital role in stroke prevention.

A team of researchers has developed a floral-scented fungus that tricks mosquitoes into approaching and dying. The fungus emits longifolene, a natural scent that irresistibly draws them in. It’s harmless to humans, inexpensive to produce, and remains potent for months. This innovative biological control could be crucial as mosquitoes spread with climate change.

Researchers found that life expectancy growth in wealthy nations has dramatically slowed since 1939. Once driven by major reductions in child mortality, longevity gains are now limited by slower progress in older-age survival. The study suggests no generation since 1939 will live to 100 on average, reshaping how societies must plan for aging and pensions.

GLP-1 drugs, originally developed for diabetes and obesity, may also curb addictive behaviors by acting on reward circuits in the brain. Early trials show reductions in alcohol intake, opioid seeking, and nicotine use. Though more research is needed, scientists believe these drugs could open a powerful new front in addiction therapy.

Researchers have uncovered microbial evidence in the remains of Napoleon’s soldiers from the 1812 Russian retreat. Genetic analysis revealed pathogens behind paratyphoid and relapsing fever, diseases likely contributing to the army’s massive losses. Using advanced DNA sequencing, the team pieced together centuries-old infection clues, connecting historical accounts with modern science. Their work redefines our understanding of how disease shaped history’s most infamous retreat.

Researchers found that combining regular exercise with omega-3 supplements can make a big difference for oral health. The duo helps the immune system fight off chronic tooth root infections and reduces bone loss around the teeth. In animal studies, those that both exercised and took omega-3s had much lower inflammation and healthier bone structure.

A new study shows that eating more fruits and vegetables during the day can significantly improve sleep that same night. Researchers found a clear link between diet quality and sleep depth, with participants who met the CDC’s daily produce recommendations seeing a 16% boost in sleep quality. The findings suggest that small dietary changes could make a big difference in how well we rest.

Researchers found that neurons can use fat, not just sugar, to power the brain. When a protein called DDHD2 fails, this process breaks down and leads to serious brain problems. Scientists were able to restore damaged cells by feeding them fatty acids, reviving their energy in just 48 hours. The discovery could help pave the way for new brain treatments.

Japanese researchers discovered that hair graying and melanoma share a surprising cellular origin. When DNA damage strikes melanocyte stem cells, they may undergo a protective process called seno-differentiation, leading to hair graying. However, carcinogens can override this safeguard, allowing the damaged cells to persist and turn cancerous. This balance between cell loss and survival reveals a hidden connection between aging and cancer.

Inside your body, an intricate communication network constantly monitors breathing, heart rate, digestion, and immune function — a hidden “sixth sense” called interoception. Now, Nobel laureate Ardem Patapoutian and a team at Scripps Research and the Allen Institute have received $14.2 million from the NIH to map this internal sensory system in unprecedented detail.

Scientists at The University of Texas at Austin have developed a revolutionary gene-editing method using bacterial retrons that can correct multiple disease-causing mutations at once. Unlike traditional tools limited to one or two mutations, this retron-based system replaces large defective DNA regions, dramatically improving efficiency and inclusivity for patients with complex disorders like cystic fibrosis.

ASU scientists found that people whose gut microbes make more methane extract more calories from fiber-rich foods. Methanogens help the microbiome turn fiber into energy by consuming hydrogen and producing methane. Using advanced metabolic chambers, researchers measured how diet and gut chemistry interact, showing that methane may signal efficient digestion. The work could lead to personalized diets based on individual microbiomes.