Biotechnology

Leafcutter ants live in highly organized colonies where every ant has a job, and now researchers can flip those jobs like a switch. By manipulating just two neuropeptides, scientists can turn defenders into nurses or gardeners into leaf harvesters. These same molecular signals echo in naked mole-rats, revealing a deep evolutionary link in how complex societies function, even across species. The study also teases out a possible connection to insulin and longevity, hinting at new frontiers in understanding human behavior and lifespan.

Lichen from the Mojave Desert has stunned scientists by surviving months of lethal UVC radiation, suggesting life could exist on distant planets orbiting volatile stars. The secret? A microscopic “sunscreen” layer that protects their vital cells—even though Earth’s atmosphere already filters out such rays.

Two Ice Age wolf pups once thought to be early dogs have been identified as wild wolves, thanks to detailed DNA and chemical analysis. Surprisingly, their last meals included woolly rhinoceros meat—an unusually large prey item—hinting that ancient wolves might have been bigger than today’s. Their well-preserved bodies also shed light on wolf pack behavior and Ice Age environments.

In a remarkable twist of science, researchers have transformed a fungus long associated with death into a potential weapon against cancer. Found in tombs like that of King Tut, Aspergillus flavus was once feared for its deadly spores. Now, scientists at Penn and several partner institutions have extracted a new class of molecules from it—called asperigimycins—that show powerful effects against leukemia cells. These compounds, part of a rare group known as fungal RiPPs, were bioengineered for potency and appear to disrupt cancer cell division with high specificity.

Even after 20 million years of evolutionary separation, two tiny worm species show astonishingly similar patterns in how they turn genes on and off. Scientists mapped every cell s activity during development and found that genes essential to basic functions like muscles and digestion remained largely unchanged. Meanwhile, genes linked to sensing the environment or brain-like functions showed more variation. This high-resolution comparison of every cell between species may help unlock mysteries of how life evolves and adapts without always changing how it looks.

Researchers investigating the enigmatic and antibiotic-resistant Pandoraea bacteria have uncovered a surprising twist: these pathogens don't just pose risks they also produce powerful natural compounds. By studying a newly discovered gene cluster called pan, scientists identified two novel molecules Pandorabactin A and B that allow the bacteria to steal iron from their environment, giving them a survival edge in iron-poor places like the human body. These molecules also sabotage rival bacteria by starving them of iron, potentially reshaping microbial communities in diseases like cystic fibrosis.

Scientists have uncovered that fish biofluorescence a captivating ability to glow in vivid colors has ancient roots stretching back over 100 million years. This trait evolved independently in reef fish more than 100 times, likely influenced by post-dinosaur-extinction reef expansion. The glowing spectacle is more diverse than previously imagined, spanning multiple colors across hundreds of species.

Sea cucumbers, long known for cleaning the ocean floor, may also harbor a powerful cancer-fighting secret. Scientists discovered a unique sugar in these marine creatures that can block Sulf-2, an enzyme that cancer cells use to spread. Unlike traditional medications, this compound doesn t cause dangerous blood clotting issues and offers a cleaner, potentially more sustainable way to develop carbohydrate-based drugs if scientists can find a way to synthesize it in the lab.

The biosynthesis of the great variety of natural plant products has not yet been elucidated for many medically interesting substances. In a new study, an international team of researchers was able to show how ipecacuanha alkaloids, substances used in traditional medicine, are synthesized. They compared two distantly related plant species and were able to show that although both plant species use a comparable chemical approach, the enzymes they need for synthesis differ and a different starting material is used. Further investigations revealed that the biosynthetic pathways of these complex chemical compounds have developed independently in the two species. These results help to enable the synthesis of these and related substances on a larger scale for medical use.

Some microbes living on sand grains use up all the oxygen around them. Their neighbors, left without oxygen, make the best of it: They use nitrate in the surrounding water for denitrification -- a process hardly possible when oxygen is present. This denitrification in sandy sediments in well-oxygenated waters can substantially contribute to nitrogen loss in the oceans.

Researchers have synthesized a new compound called infuzide that shows activity against resistant strains of pathogens.

Scientists in Australia have developed a smart, bacteria-repelling coating based on resilin the ultra-elastic protein that gives fleas their legendary jumping power. When applied to surfaces like medical implants or surgical tools, the engineered resilin forms nano-droplets that physically disrupt bacterial cells, including antibiotic-resistant strains like MRSA, without harming human tissue. In lab tests, the coating was 100% effective at keeping bacteria from sticking and forming biofilms, a key cause of infection after surgery.

Laboratory could improve crop resilience In a discovery three decades in the making, scientists have acquired detailed knowledge about the internal structures and mode of regulation for a specialized protein and are proceeding to develop tools that can capitalize on its ability to help plants combat a wide range of diseases. The work, which exploits a natural process where plant cells die on purpose to help the host plant stay healthy, is expected to have wide applications in the agricultural sector, offering new ways to protect major food crops from a variety of devastating diseases, the scientists said.

To achieve the European Green Deal's goal of 25% organic agriculture by 2030, researchers argue that new genomic techniques (NGTs) should be allowed without pre-market authorization in organic as well as conventional food production. NGTs -- also known as gene editing --- are classified under the umbrella of GMOs, but they involve more subtle genetic tweaks.

The process of necrosis, a form of cell death, may represent one of the most promising ways to change the course of human aging, disease and even space travel, according to a new study.

A professor of crop sciences and of plant biology describes research efforts to 'future-proof' the crops that are essential to feeding a hungry world in a changing climate. Long, who has spent decades studying the process of photosynthesis and finding ways to improve it, provides an overview of key scientific findings that offer a ray of hope.

Researchers have identified a monoacylglycerol acyltransferase-coding gene named bishu-1. It is involved in the thermal responsiveness of cool temperature-sensing neurons by regulating ionotropic receptor expression, thereby maintaining the cool temperature avoidance behaviors in Drosophila larvae.

New HIV research shows that small changes in the virus affect how quickly or slowly it replicates and how easily it can reawaken in the body. These insights bring researchers closer to finding ways to flush out the dormant virus and eliminate it for good.

Scientists analyzed almost 200 cannabis genomes to create the most comprehensive, high-quality, detailed genetic atlas of the plant to date. The atlas reveals unprecedented diversity and complexity within the species, sets the stage for advances in cannabis-based agriculture, medicine, and industry, and builds on a 10,000-year long relationship between humans and cannabis, showing that cannabis can be as important as other crops like corn or wheat.

The protein DNase1 is one of the oldest biological agents in history: It has been on the market since 1958 and is now used, among other things, to treat cystic fibrosis. However, it takes considerable effort to produce it in immortalized hamster cells. This process is also costly. It would be far more cost-effective to produce it with undemanding yeast cells.

Scientists have developed a unified theory for mathematical parameters known as gauge freedoms. Their new formulas will allow researchers to interpret research results much faster and with greater confidence. The development could prove fundamental for future efforts in agriculture, drug discovery, and beyond.

Chemists have demonstrated how RNA (ribonucleic acid) might have replicated itself on early Earth -- a key process in the origin of life.

Researchers find high-fat diets set off metabolic dysfunction in cells, leading to weight gain, but these effects can be reversed by treatment with an antioxidant.

A team identified herpes virus saimiri, which infects the T cells of squirrel monkeys, as a source of proteins that activate pathways in T cells that are needed to promote T cell survival.

Scientists have discovered cells in the skin of Atlantic salmon that offer new insights into how wounds heal, tissues regenerate, and cellular transitions support long-term skin health.

Flowers grow stems, leaves and petals in a perfect pattern again and again. A new study shows that even in this precise, patterned formation in plants, gene activity inside individual cells is far more chaotic than it appears.

A gene that regulates the development of roots in vascular plants is also involved in the organ development of liverworts -- land plants so old they don't even have proper roots. The discovery highlights the fundamental evolutionary dynamic of co-opting, evolving a mechanism first and adopting it for a different purpose later.

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden rules that should be considered to build a functional enzyme.

The molecular pathways involved in antiviral defenses and counter-defenses in host-pathogen systems remain unclear. Researchers have used Neurospora crassa as a model organism to explore how RNA editing influences fungal antiviral responses. They identified two neighboring genes -- an RNA-editing enzyme (old) and a transcription factor (zao) -- that regulate virus-induced gene expression. Their findings show how the old-zao module controls both asymptomatic and symptomatic infections, providing new insight into conserved antiviral mechanisms in fungi.

Proteins catalyze life by changing shape when they interact with other molecules. The result is a muscle twitching, the perception of light, or a bit of energy extracted from food. The ability to engineer shapeshifting proteins opens new avenues for medicine, agriculture, and beyond.

A new study proves that a type of genetic element called 'introners' are the mechanism by which many introns spread within and between species, also providing evidence of eight instances in which introners have transferred between unrelated species in a process called 'horizontal gene transfer,' the first proven examples of this phenomenon.

The bacteria that cause tuberculosis (TB) may have an 'on-off switch' that lets them pause and restart growth, according to a new study. The research helps explain why TB is so hard to treat with antibiotics and could pave the way for better drugs.

If you've ever regretted ordering a spicy meal, take note: A new study identifying molecules that suppress the heat of chili peppers hints at the possibility of adapting these compounds into an 'anti-spice' condiment for food that's too fiery to eat. The research helps explain differences in chili pepper pungency, or spiciness, by identifying three compounds in a range of pepper samples that chemical analysis predicted, and study participants on a tasting panel confirmed, are linked to lower heat intensity.

A study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy.

Researchers have shown that gonadotrophs, cells in the pituitary gland with a key role in puberty and reproduction, come from two different populations, with the majority produced after birth rather than in the embryo, as previously thought.

Bats are known as natural hosts for highly pathogenic viruses such as MERS- and SARS-related coronaviruses, as well as the Marburg and Nipah viruses. In contrast to the severe and often fatal disease outcomes these viruses cause in humans, bats generally do not show obvious signs of viral illness following infection. An international research team has developed an innovative organoid research platform that allowed them to closely investigate the cellular antiviral defense mechanisms of mucosal epithelial tissues of bats. The results could pave the way for the development of new therapies against viral diseases.

New research demonstrates how specially engineered bacteria taken orally can operate as a delivery system for vaccines and antiviral therapies.

Antimicrobial resistance is a growing issue in aquaculture. Researchers discovered that combinations of bacteria from live-feed microalgae are capable of inhibiting pathogens.

With its fascinating ability to regrow entire limbs and internal organs, the Mexican axolotl is the ideal model for studying regeneration. Scientists have now found a factor that tells cells which part of the arm to regenerate -- and used it to reprogram the identity of cells as they develop. This breakthrough for the regeneration research field has implications for tissue engineering, including in human tissues.

Cancer cells respond to stress with greater diversity. Drugs that affect DNA replication, or radiation that causes direct DNA damage, lead to increasingly diverse offspring over multiple cell generations. This increases the tumor's genetic complexity and facilitates the development of resistance to therapy. Researchers have now investigated the emergence of cellular diversity in real time.

A team of researchers studied the properties of membranes to understand how these cellular structures influenced the chemistry of life on Earth as it began.

A study has used advanced genetic and genomic techniques to offer a major step forward in understanding and diagnosing infectious intestinal diseases. The large-scale study analyzed more than 1,000 stool samples from people with diarrheal illness to harness two cutting edge tools. The study used metagenomic (DNA-based) and metatranscriptomic (gene or RNA-based) sequencing. Unlike traditional methods, these techniques do not rely on growing organisms in a lab. Instead, they detect and analyze the genetic material directly from patient samples.

Scientists have elucidated the molecular mechanism by which LEM-3 cuts DNA bridges during cytokinesis.

Researchers have shown that the evolution of a family of exported proteins in the malaria-causing parasite Plasmodium falciparum enabled it to infect humans.

The demand for the widely used cancer drug Taxol is increasing, but it's difficult and expensive to produce because it hasn't been possible to do it biosynthetically. Until now, that is. Researchers have now cracked the last part of a code that science has struggled with for 30 years. The breakthrough could halve the price of the drug and make production far more sustainable.

A team was able to show that swimming movements are possible even without a central control unit. This not only explains the behavior of microorganisms, it could also enable nanobots to move in a targeted manner, for example to transport drugs to the right place in the body.

Newly discovered weapons of bacterial self-defense take different approaches to achieving the same goal: preventing a virus from spreading through the bacterial population.

Taste, pain, or response to stress -- nearly all essential functions in the human body are regulated by molecular switches called G protein-coupled receptors (GPCRs). Researchers have uncovered the fundamental mechanism how such a GPCR works. Using a method similar to the earth satellite GPS, they could track the motions of a GPCR and observe it in action. Their findings provide guidance for designing drugs.

Researchers have designed a high-performance, open-access continuous flow process to safely produce key antibacterial drugs from bio-based furfural.

Thetis cells, a class of immune cells first described in 2022, play an essential and previously unknown role in suppressing inflammatory responses to food, a new study finds.

An international research team has discovered a critical protein that acts as a 'switch' regulating immune responses to viruses.

Many an orange cat-affiliated human will vouch for their cat's, let's say, specialness. But now scientists have confirmed that there is, in fact, something unique about ginger-hued domestic felines. In a new study, researchers have discovered the long-posited but elusive genetic mutation that makes orange cats orange -- and it appears to occur in no other mammal.

We might have another reason to enjoy our daily cup of tea or small piece of dark chocolate, as a new study has found that naturally occurring compounds called flavan-3-ols -- found in cocoa, tea, apples and grapes -- may improve blood pressure and the health of our blood vessels.

Scientists are using artificial intelligence to determine which genes collectively govern nitrogen use efficiency in plants such as corn, with the goal of helping farmers improve their crop yields and minimize the cost of nitrogen fertilizers.

The northern white rhinoceros is one of the rarest animals on Earth, with just two females left and no natural way for the species to reproduce. Now, scientists have mapped the entire genome of a northern white rhino. This represents a crucial step toward bringing the critically endangered species back from the edge using advanced reproductive technologies. The complete genome can be used as a reference to analyze the health of previously developed northern white rhinoceros stem cells. Eventually, those stem cells may be able to generate sperm and eggs to yield new rhinos.

Researchers have developed a novel technology that allows the distribution of components within a single cell to be accurately detected and visualized. Positioning a t-SPESI (tapping-mode scanning probe electrospray ionization) unit above an inverted fluorescence microscope allows visualization of both the sample and the exact location of chemical components analyzed. This provides an increased understanding of complex biological samples, aiding the development of advanced therapies and diagnostic techniques.

An international team of researchers has discovered saarvienin A, a new type of glycopeptide antibiotic. Their findings introduce a compound with strong activity against highly resistant bacterial strains.

When biting into a chili pepper, you expect a fiery sensation on your tongue. This spiciness is detected because of capsaicinoid compounds. But for some peppers, despite high levels of capsaicinoids, the heat is mysteriously dull. Now, researchers have identified three compounds that lessen peppers' pungency. These results challenge the reliability of the century-old Scoville scale, which traditionally bases its rating on two capsaicinoids.

Using a new fluorescent mouse model with advanced imaging techniques, researchers have successfully visualized how musculoskeletal components are integrated into the functional locomotor system during embryonic development.

With coral reefs in crisis due to climate change, scientists have engineered a bio-ink that could help promote coral larvae settlement and restore these underwater ecosystems before it's too late. Researchers demonstrate that the ink could boost coral settlement by more than 20 times, which they hope could contribute to rebuilding coral reefs around the world.