Pharmaceuticals

People taking semaglutide report far fewer obsessive thoughts about food, with cravings dropping sharply and mental health improving. This new research hints the drug may offer freedom from the constant distraction of food noise.

Preschoolers with ADHD are often given medication right after diagnosis, against medical guidelines that recommend starting with behavioral therapy. Limited access to therapy and physician pressures drive early prescribing, despite risks and reduced effectiveness in young children.

Scientists discovered that a gut bacteria molecule called corisin can travel to the kidneys, triggering inflammation and scarring that lead to diabetic kidney fibrosis. By attaching to albumin in the blood, corisin infiltrates kidney tissue and accelerates damage. In animal studies, antibodies that neutralize corisin slowed disease progression, offering hope for new treatments beyond dialysis and transplants.

New research suggests that immunotherapy given before and after surgery could help patients with diffuse pleural mesothelioma, one of the most challenging cancers to treat. A phase II clinical trial tested immunotherapy in resectable cases, with promising results presented at the World Conference on Lung Cancer.

Metformin, long trusted for diabetes, turns out to work in the brain too. By shutting down Rap1 in the hypothalamus, the drug lowers blood sugar more effectively than previously understood, opening doors for new therapies.

Scientists discovered seven molecules in the blood linked to excessive daytime sleepiness, a condition that affects one in three Americans and raises the risk of heart disease, obesity, and diabetes. The study highlights the role of both diet and hormones, finding that omega-3 and omega-6 fatty acids may protect against drowsiness, while compounds like tyramine may worsen it.

Sucralose, the sugar substitute in many diet products, may weaken cancer immunotherapy by altering gut bacteria and reducing arginine levels needed for immune cells. But supplementation with arginine or citrulline could counteract this effect, pointing to new clinical trial possibilities.

Drinking nitrate-rich beetroot juice lowered blood pressure in older adults by reshaping their oral microbiome, according to researchers at the University of Exeter. The study found that beneficial bacteria increased while harmful ones decreased, leading to better conversion of dietary nitrates into nitric oxide—a molecule vital for vascular health.

Harvard scientists have uncovered that lithium, a naturally occurring element in the brain, may be the missing piece in understanding Alzheimer’s. Their decade-long research shows that lithium depletion—caused by amyloid plaques binding to it—triggers early brain changes that lead to memory loss. By testing new lithium compounds that evade plaque capture, they reversed Alzheimer’s-like damage and restored memory in mice at doses far lower than those used in psychiatric treatments.

For people with macular telangiectasia type 2 (MacTel), an orphan retinal disorder that gradually destroys central vision, there have long been no approved treatment options. But now, a new study sponsored by Neurotech Pharmaceuticals and spearheaded by investigators at Scripps Research and the National Institutes of Health offers compelling evidence that vision loss can be slowed with a neuroprotective surgical implant.

Painkillers we often trust — ibuprofen and acetaminophen — may be quietly accelerating one of the world’s greatest health crises: antibiotic resistance. Researchers discovered that these drugs not only fuel bacterial resistance on their own but make it far worse when combined with antibiotics. The findings are especially troubling for aged care settings, where residents commonly take multiple medications, creating perfect conditions for resistant bacteria to thrive.

Researchers uncovered that hypothalamic neurons safeguard blood sugar overnight by directing fat breakdown, preventing hypoglycemia during early sleep. This subtle control system may explain abnormal metabolism in prediabetes.

Researchers have created plant-based microbeads that trap fat in the gut, helping rats lose weight without side effects. Unlike current drugs, the beads are safe, tasteless, and easy to mix into everyday foods. Human trials are now underway.

Scientists have engineered a groundbreaking cancer treatment that uses bacteria to smuggle viruses directly into tumors, bypassing the immune system and delivering a powerful one-two punch against cancer cells. The bacteria act like Trojan horses, carrying viral payloads to cancer’s core, where the virus can spread and destroy malignant cells. Built-in safety features ensure the virus can’t multiply outside the tumor, offering a promising pathway for safe, targeted therapy.

A groundbreaking study has found that a simple change in walking style can ease osteoarthritis pain as effectively as medication—without the side effects. By adjusting foot angle, participants reduced knee stress, slowed cartilage damage, and maintained the change for over a year.

Arizona State University scientists have unveiled NasRED, a revolutionary one-drop blood test that can detect diseases like COVID-19, Ebola, HIV, and Lyme with incredible speed and precision. Using gold nanoparticles to spot microscopic disease markers, the device delivers results in just 15 minutes—outperforming traditional lab tests in sensitivity, speed, and affordability. Portable and costing only $2 per test, it could be deployed from remote clinics to urban hospitals, offering a lifeline for early detection and outbreak control worldwide.

Stopping prescription weight loss drugs often leads to significant weight regain, according to a large-scale analysis of 11 global studies. Researchers found that although these medications, including GLP-1-based treatments like semaglutide and tirzepatide, help patients lose substantial weight while in use, gains tend to return within weeks of stopping.

In an exciting breakthrough, researchers have identified cancer drugs that might reverse the effects of Alzheimer's disease in the brain. By analyzing gene expression in brain cells, they discovered that some FDA-approved cancer medications could reverse damage caused by Alzheimer's.

A mysterious gut hormone may be behind many cases of chronic diarrhea, especially in people with undiagnosed bile acid malabsorption, a condition often mistaken for irritable bowel syndrome. Researchers from the University of Cambridge identified that the hormone INSL5 spikes when bile acid reaches the colon, triggering intense diarrhea. Their discovery not only sheds light on the biological cause of symptoms but opens the door to a diagnostic blood test and new treatment options, including a surprising existing drug that blocks this hormone’s effects.

A team of scientists has developed a remarkable new approach to modeling how cells behave over time—using a digital "forecast" much like predicting the weather. By combining patient genomics with a groundbreaking plain-language “hypothesis grammar,” the researchers can simulate how cells communicate and evolve within tissues. These simulations allow scientists to digitally test how cancers grow, how immune systems respond, and even how treatments might work in individual patients.

A virus from humble black-eyed peas is showing extraordinary promise in the fight against cancer. Unlike other plant viruses, the cowpea mosaic virus (CPMV) can awaken the human immune system and transform it into a cancer-fighting powerhouse, without infecting human cells. By comparing it to a similar, but ineffective, virus, researchers uncovered that CPMV uniquely triggers potent interferons and immune responses, making it a low-cost, plant-grown immunotherapy on the fast track toward clinical trials.

A massive global survey has revealed that people with eating disorders often turn to cannabis and psychedelics like magic mushrooms and LSD to ease their symptoms, rating them more effective than traditional medications. Surprisingly, common prescriptions like antidepressants were seen as helpful for overall mental health but fell short for eating disorder relief.

Radiation therapy, once thought of mainly as a local cancer treatment, is now showing power to awaken the immune system in surprising ways. Researchers discovered that combining radiation with immunotherapy can transform stubborn, unresponsive lung tumors into targets for immune attack—especially those considered “cold” and typically resistant. This happens through a rare and poorly understood effect where immune cells are activated systemically, not just at the radiation site. Patients whose tumors underwent this “warm-up” had significantly better outcomes, revealing a promising new strategy for fighting hard-to-treat cancers.

Artificial intelligence is now designing custom proteins in seconds—a process that once took years—paving the way for cures to diseases like cancer and antibiotic-resistant infections. Australian scientists have joined this biomedical frontier by creating bacteria-killing proteins with AI. Their new platform, built by a team of biologists and computer scientists, is part of a global movement to democratize and accelerate protein design for medical breakthroughs.

In a remarkable twist of science, researchers have transformed a fungus long associated with death into a potential weapon against cancer. Found in tombs like that of King Tut, Aspergillus flavus was once feared for its deadly spores. Now, scientists at Penn and several partner institutions have extracted a new class of molecules from it—called asperigimycins—that show powerful effects against leukemia cells. These compounds, part of a rare group known as fungal RiPPs, were bioengineered for potency and appear to disrupt cancer cell division with high specificity.

Colistin, a last-resort antibiotic, is losing its power due to rising resistance—and the culprits might be hiding in your seafood dinner. A University of Georgia research team discovered colistin-resistance genes in bacteria found in imported shrimp and scallops from markets in Atlanta. These genes can hop between bacteria via plasmids, potentially turning once-curable infections into deadly threats.

Fresh concerns have emerged about the platelet studies underpinning the FDA approval of ticagrelor, AstraZeneca's multibillion-dollar heart drug. A new BMJ investigation reveals data discrepancies, missing lab readings, and questions about the integrity of the trial process. Notably, key results reported in a major cardiology journal were inaccurately presented, and some study contributors were omitted or denied involvement. With generics on the horizon, critics say these revelations highlight potential dangers, including severe rebound effects and bleeding risks, that were never properly disclosed.

A team at Kobe University has created a game-changing resource for autism research: 63 mouse embryonic stem cell lines, each carrying a genetic mutation strongly associated with the disorder. By pairing classic stem cell manipulation with precise CRISPR gene editing, they ve built a standardized platform that mirrors autism-linked genetic conditions in mice. These models not only replicate autism-related traits but also expose key dysfunctions, like the brain s inability to clean up faulty proteins.

A new Rutgers Health study reveals a surprising twist in the antibiotic resistance story: instead of simply killing bacteria, drugs like ciprofloxacin can actually trigger a kind of microbial survival mode. By crashing the bacteria's energy levels, the antibiotic causes E. coli to ramp up its metabolism, survive attacks, and mutate faster ultimately accelerating the evolution of drug resistance.

A breakthrough study from Keck Medicine of USC may have found a powerful new triple therapy for glioblastoma, one of the deadliest brain cancers. By combining Tumor Treating Fields (TTFields), which deliver electric waves into tumors, with immunotherapy and chemotherapy, researchers saw a major boost in survival.

Chronic inflammatory bowel disease is challenging to treat and carries a risk of complications, including the development of bowel cancer. Young people are particularly affected: when genetic predisposition and certain factors coincide, diseases such as ulcerative colitis or Crohn's disease usually manifest between the ages of 15 and 29 -- a critical period for education and early career development. Prompt diagnosis and treatment are crucial. Researchers have now discovered a therapeutic target that significantly contributes to halting the ongoing inflammatory processes.

Scientists in Australia have developed a smart, bacteria-repelling coating based on resilin the ultra-elastic protein that gives fleas their legendary jumping power. When applied to surfaces like medical implants or surgical tools, the engineered resilin forms nano-droplets that physically disrupt bacterial cells, including antibiotic-resistant strains like MRSA, without harming human tissue. In lab tests, the coating was 100% effective at keeping bacteria from sticking and forming biofilms, a key cause of infection after surgery.

An international clinical trial shows an innovative CAR-T cell immunotherapy is promising against aggressive T cell cancers and has manageable side effects.

Current regulations for nanomedicines overlook the effects of the different forms of the same element, such as ions, nanoparticles, and aggregates. In a recent study, researchers developed a new analytical method combining an asymmetric flow field-flow fractionation system and mass spectrometry to separately quantify these forms. This technique allows for better quality control and safety evaluation of metal-based nanomedicines, promoting their development and clinical use, with applications also extending to food, cosmetics, and the environment.

Parasitic worms that infect humans are not interbreeding with those that infect cattle as previously thought. This is good news for when it comes to controlling schistosomiasis, a disease caused by these worms that affects more than 200 million people globally.

Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events. Despite clinicians recommending that many patients with diabetes take statins, nearly one-fifth of them opt to delay treatment. In a new study, researchers found that patients who started statin therapy right away reduced the rate of heart attack and stroke by one third compared to those who chose to delay taking the medication.

Scientists have fabricated two bed netting prototypes targeting malaria-causing blood parasites. They designed netting systems to deliver antimalarial drugs called Endochin-like Quinolones (ELQs) that destroy Plasmodium parasites transmitted by mosquitoes.

New research demonstrates how specially engineered bacteria taken orally can operate as a delivery system for vaccines and antiviral therapies.

SSRIs boosted the ability of T cells to kill cancer cells and suppressed tumor growth in both mouse and human tumor models.

MIT researchers found a way to measure cell density quickly and accurately -- measuring up to 30,000 cells in a single hour. They also showed density changes could be used to make useful predictions, including whether T cells have become activated to kill tumors or whether tumor cells are susceptible to a specific drug.

An unprecedented international effort to decode how cells manage the transport of chemical substances has culminated in four groundbreaking studies This decade-long project provides the first comprehensive functional blueprint of chemical transport pathways in human cells.

Researchers have discovered how a parasite that causes malaria when transmitted through a mosquito bite can hide from the body's immune system, sometimes for years. It turns out that the parasite, Plasmodium falciparum, can shut down a key set of genes, rendering itself 'immunologically invisible.'

Scientists report that they have learned how certain combinations of rearranged genes can promote the progression of a rare type of kidney cancer.

A recent study reveals that the average duration of ADHD medication for children and adolescents is more than three years. However, reliable, controlled data on the safety of marketed ADHD medicines in children are available for only one year of follow-up.

Some patients with lupus who possess specific antibodies are at a higher risk of thrombotic events such as a blood clot, stroke or heart attack, a new study shows. The finding might help clinicians determine which patients may need early treatment and clinical monitoring for thrombotic events.

An international team of researchers has discovered saarvienin A, a new type of glycopeptide antibiotic. Their findings introduce a compound with strong activity against highly resistant bacterial strains.

A new treatment approach significantly improves survival rates for patients with aggressive, inherited breast cancers, according to researchers. In a trial where cancers were treated with chemotherapy followed by a targeted cancer drug before surgery, 100% of patients survived the critical three-year period post-surgery.

AI model EVE-Vax provides clues about how a virus may evolve and the immune response it could provoke.

A new strategy may help prevent or slow the progression of Type 1 diabetes.

Groundbreaking device instantly detects dangerous street drugs, offering hope for harm reduction A portable device that instantly detects illicit street drugs at very low concentrations, thereby highlighting the risks they pose. The device has the potential to address the growing global problem of people unknowingly taking drugs that have been mixed with undeclared substances, including synthetic opioids such as fentanyl and nitazenes.

Bacterial resistance negates the effect of antibiotics in the treatment of infection. Using mouse models, researchers now show that if antibiotics are administered with an enzyme called endolysin, the combined effect protects against infection by resistant bacteria in all bodily organs -- including the brain, which antibiotics alone have difficulty reaching.

Scientists have identified essential genetic code for a method called plasmid curing, which aims to 'displace' antibiotic resistance genes from bacteria.

Ear infections are a common and painful occurrence in infants and toddlers. Oral antibiotics are often prescribed for a week to treat the condition, but these drugs can trigger side effects that disrupt treatment, which can lead to infection recurrence and antibiotic resistance. Now, researchers report a topical antibiotic gel that, applied once, cured middle ear infection within 24 hours in chinchillas.

Chemists found a way to identify a complex sugar molecule in the cell walls of Mycobacterium tuberculosis, the world's deadliest pathogen. This labeling could lead to simpler, faster TB tests.

A new approach to drug design can deliver medicine directly to the gut in mice at significantly lower doses than current inflammatory bowel disease treatments. The proof-of-concept study introduced a mechanism called 'GlycoCaging' that releases medicine exclusively to the lower gut at doses up to 10 times lower than current therapies.

Recent disease modeling research challenges public health guidelines recommending conservative antibiotic use for cholera, suggesting that for some outbreaks, prescribing antibiotics more aggressively could slow or stop the spread of the disease and even reduce the likelihood of antibiotic resistance.

Artificial intelligence algorithms have now been combined with traditional laboratory methods to uncover promising drug leads against human enterovirus 71 (EV71), the pathogen behind most cases of hand, foot and mouth disease. The study showed that reliable antiviral predictions can be made even when only a modest amount of experimental data are available.

Depression, schizophrenia and other mental health conditions affect 1 in 4 people in their lifetime, but mechanisms underlying these conditions are poorly understood. New research has linked the body's immune response with schizophrenia, Alzheimer's disease, depression, and bipolar disorder. The study demonstrates mental health conditions might be affected by the whole body as well as changes in the brain. The findings could pave the way for better treatments of some mental health conditions.

Scientists built a model that allows them to diminish phage communities from a mouse gut microbiome -- and then bring them back -- without affecting the bacteria. On a test run of their model, researchers found evidence that phages may increase gut bacteria's sensitivity to antibiotics.

A new study has identified a specific mode of fat uptake by immune cells within tumors that serves as a metabolic checkpoint against anti-cancer immune responses.