Medical and Health Sciences

Researchers have identified a promising new weapon against triple-negative breast cancer, one of the most aggressive forms of the disease. An experimental antibody targets a protein that fuels tumor growth and shuts down immune defenses, effectively turning the immune system back on. In early tests, the treatment slowed tumor growth, reduced lung metastases, and destroyed chemotherapy-resistant cancer cells.

Type 2 diabetes becomes more dangerous to the heart the longer a person has it. Researchers found that after several years, red blood cells can begin interfering with healthy blood vessel function. This harmful shift was not present in newly diagnosed patients but emerged over time. A small molecule inside blood cells may help flag rising cardiovascular risk early.

A new study reveals that super agers over 80 have a distinct genetic edge. They are much less likely to carry the gene most associated with Alzheimer’s risk, even when compared with other healthy seniors. Researchers also found higher levels of a protective gene variant in this group. Together, the findings help explain why some people age with remarkably youthful minds.

A new blood test may reveal Crohn’s disease years before symptoms begin. The test detects an unusual immune response to gut bacteria in people who later develop the condition. By studying healthy relatives of Crohn’s patients, researchers identified early warning signals long in advance. The findings raise hope for earlier diagnosis and future prevention.

Scientists found that nasal cells act as a first line of defense against the common cold, working together to block rhinovirus soon after infection. A fast antiviral response can stop the virus before symptoms appear. If that response is weakened or delayed, the virus spreads and causes inflammation and breathing problems. The study highlights why the body’s reaction matters more than the virus alone.

Scientists studying genetic data from over a quarter million people have uncovered new clues about what controls how fast the gut moves. They identified multiple DNA regions linked to bowel movement frequency, confirming known gut pathways and revealing new ones. The biggest surprise was a strong connection to vitamin B1, a common nutrient not usually linked to digestion.

Fungal infections are becoming deadlier as drug resistance spreads and treatment options stall. Researchers at McMaster University discovered that a molecule called butyrolactol A can dramatically weaken dangerous fungi, allowing existing antifungal drugs to work again. Instead of killing the fungus directly, the molecule sabotages a vital internal system, leaving the pathogen exposed. The breakthrough could help revive an entire class of antifungal medicines once thought obsolete.

New research suggests that consistent aerobic exercise can help keep your brain biologically younger. Adults who exercised regularly for a year showed brains that appeared nearly a year younger than those who didn’t change their habits. The study focused on midlife, a critical window when prevention may offer long-term benefits. Even small shifts in brain age could add up over decades.

A major global study suggests that a hidden mismatch between two common blood tests could quietly signal serious trouble ahead. When results from creatinine and cystatin C—two markers used to assess kidney health—don’t line up, the risk of kidney failure, heart disease, and even death appears to rise sharply. Researchers found that this gap is especially common among hospitalized and older patients, and that relying on just one test may miss early warning signs.

Researchers from New England Biolabs (NEB®) and Yale University describe the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa, an antibiotic-resistant bacterium of global concern, in a new PNAS study. The system is enabled by NEB’s High-Complexity Golden Gate Assembly (HC-GGA) platform. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.

Scientists have discovered that the human brain understands spoken language in a way that closely resembles how advanced AI language models work. By tracking brain activity as people listened to a long podcast, researchers found that meaning unfolds step by step—much like the layered processing inside systems such as GPT-style models.

A new study suggests that micro-doses of THC could help counter many long-term side effects of HIV treatment without causing intoxication. In animal models, low-dose THC reduced inflammation, improved gut bacteria, boosted serotonin, and lowered harmful cholesterol and bile acids. Surprisingly, it also reduced circulating levels of antiretroviral drugs while maintaining viral suppression, potentially protecting the liver. Scientists say the results point to a promising new approach for managing chronic complications of HIV.

Scientists at Stanford Medicine have discovered a treatment that can reverse cartilage loss in aging joints and even prevent arthritis after knee injuries. By blocking a protein linked to aging, the therapy restored healthy, shock-absorbing cartilage in old mice and injured joints, dramatically improving movement and joint function. Human cartilage samples from knee replacement surgeries also began regenerating when exposed to the treatment.

Researchers report that vagus nerve stimulation helped many people with long-standing, treatment-resistant depression feel better—and stay better—for at least two years. Most participants had lived with depression for decades and had exhausted nearly every other option. Those who improved at one year were very likely to maintain or increase their gains over time. Even some patients who didn’t respond initially improved after longer treatment.

Scientists have uncovered why people with chronic kidney disease so often die from heart problems: damaged kidneys release tiny particles into the bloodstream that actively poison the heart. These particles, produced only by diseased kidneys, carry genetic material that disrupts heart function and can lead to heart failure.

Researchers have identified a key molecular interaction that accelerates Parkinson’s disease by damaging the brain’s energy systems. They designed a new treatment that intercepts this harmful process, protecting brain cells and restoring their function. In lab and animal models, the approach improved movement and cognitive performance while reducing inflammation. The findings point toward a new generation of Parkinson’s therapies aimed at the root cause, not just the symptoms.

When you’re short on sleep and your focus suddenly drifts, your brain may be briefly slipping into cleanup mode. Scientists discovered that these attention lapses coincide with waves of fluid washing through the brain, a process that usually happens during sleep. It’s the brain’s way of compensating for missed rest. Unfortunately, that internal cleaning comes at the cost of momentary mental shutdowns.

Ibuprofen may be doing more than easing aches and pains—it could also help reduce the risk of some cancers. Studies have linked regular use to lower rates of endometrial and bowel cancer, likely because the drug dampens inflammation that fuels tumor growth. Researchers have even found it can interfere with genes cancer cells rely on to survive. Still, experts warn that long-term use carries risks and shouldn’t replace proven prevention strategies.

Researchers have found a reliable way to grow helper T cells from stem cells, solving a major challenge in immune-based cancer therapy. Helper T cells act as the immune system’s coordinators, helping other immune cells fight longer and harder. The team discovered how to precisely control a key signal that determines which type of T cell forms. This advance could lead to ready-made cell therapies that are cheaper, faster, and easier to access.

Scientists have uncovered a surprising reason why some chronic wounds refuse to heal, even when treated with antibiotics. A common bacterium found in long-lasting wounds does not just resist drugs. It actively releases damaging molecules that overwhelm skin cells and stop them from repairing tissue. Researchers discovered that neutralizing these harmful molecules with antioxidants allows skin cells to recover and restart healing.

Scientists have uncovered new clues about why diabetic foot infections can become so severe and difficult to treat. By analyzing the DNA of E. coli bacteria taken from infected wounds around the world, researchers found an unexpected level of diversity, with many strains carrying genes linked to antibiotic resistance and aggressive disease. Rather than a single dangerous strain, multiple types of E. coli appear able to thrive in diabetic foot ulcers, helping explain why infections can worsen quickly and sometimes lead to amputation.

A major new scientific review brings reassuring news for expectant parents: using acetaminophen, commonly known as Tylenol, during pregnancy does not increase a child’s risk of autism, ADHD, or intellectual disability. Researchers analyzed 43 high-quality studies, including powerful sibling comparisons that help separate medication effects from genetics and family environment. Earlier warnings appear to have been driven by underlying maternal health factors such as fever or pain rather than the medication itself.

Scientists at Johns Hopkins have uncovered a surprising new way to influence brain activity by targeting a long-mysterious class of proteins linked to anxiety, schizophrenia, and movement disorders. Once thought to be mostly inactive, these proteins—called GluDs—turn out to play an active role in how brain cells communicate and form connections.

Researchers found that autistic and non-autistic people move their faces differently when expressing emotions like anger, happiness, and sadness. Autistic participants tended to rely on different facial features and produced more varied expressions, which can look unfamiliar to non-autistic observers. The study suggests emotional misunderstandings are a two-way street, not a one-sided deficit.

Cannabis-based medicines have been widely promoted as a potential answer for people living with chronic nerve pain—but a major new review finds the evidence just isn’t there yet. After analyzing more than 20 clinical trials involving over 2,100 adults, researchers found no strong proof that cannabis products outperform placebos in relieving neuropathic pain. Even when small improvements were reported, especially with THC-CBD combinations, they weren’t large enough to make a real difference in daily life.

Scientists have discovered that breast cancer can quietly throw the brain’s internal clock off balance—almost immediately after cancer begins. In mice, tumors flattened the natural daily rhythm of stress hormones, disrupting the brain-body feedback loop that regulates stress, sleep, and immunity. Remarkably, when researchers restored the correct day-night rhythm in specific brain neurons, stress hormone cycles snapped back into place, immune cells flooded the tumors, and the cancers shrank—without using any anti-cancer drugs.

While social media continues to circulate claims linking acetaminophen to autism in children, medical experts say those fears distract from a far more serious and proven danger: overdose. Acetaminophen, found in Tylenol and many cold and flu remedies, is one of the leading causes of emergency room visits, hospitalizations, and acute liver failure in the United States.

When scientists sent bacteria-infecting viruses to the International Space Station, the microbes did not behave the same way they do on Earth. In microgravity, infections still occurred, but both viruses and bacteria evolved differently over time. Genetic changes emerged that altered how viruses attach to bacteria and how bacteria defend themselves. The findings could help improve phage therapies against drug-resistant infections.

A long-running Swedish study has followed adults for nearly five decades, uncovering when physical decline truly begins. Fitness and strength start slipping around age 35, then worsen gradually with age. The encouraging twist: adults who began exercising later still improved their physical capacity by up to 10 percent. It’s a powerful reminder that staying active matters, even if you start late.

Thyme extract is packed with health-promoting compounds, but it is difficult to control and easy to waste. Researchers created a new technique that traps tiny amounts of the extract inside microscopic capsules, preventing evaporation and irritation. The method delivers consistent nanodoses and could eventually be used in medicines or food products. It may also work for many other natural extracts.

Researchers have turned artificial intelligence into a powerful new lens for understanding why cancer survival rates differ so dramatically around the world. By analyzing cancer data and health system information from 185 countries, the AI model highlights which factors, such as access to radiotherapy, universal health coverage, and economic strength, are most closely linked to better survival in each nation.

Scientists are uncovering a hidden and surprisingly complex earthquake zone beneath Northern California by tracking swarms of tiny earthquakes that are far too weak to feel. These faint tremors are revealing what lies beneath the surface where the San Andreas fault meets the Cascadia subduction zone, one of the most dangerous seismic regions in North America.

A simple change in how primary care clinics approach weight management is delivering big public health wins. PATHWEIGH lets patients openly request help and gives doctors the tools to focus entire visits on weight care. In a massive real-world trial, the program halted population weight gain and increased access to obesity treatment. Now, health systems across the U.S. are lining up to adopt it.

Bamboo shoots may be far more than a crunchy side dish. A comprehensive review found they can help control blood sugar, support heart and gut health, and reduce inflammation and oxidative stress. Laboratory and human studies also suggest bamboo may promote beneficial gut bacteria and reduce toxic compounds in cooked foods. However, bamboo must be pre-boiled to avoid natural toxins.

Moderate video gaming appears harmless, but heavy gaming may take a toll on young people’s health. Researchers found that students gaming more than 10 hours a week had worse diets, higher body weight, and poorer sleep than lighter gamers. Below that level, health outcomes were largely similar. The findings suggest balance, not abstinence, is key.

A new study warns that a widely used eye ointment can damage a popular glaucoma implant. Researchers found that oil-based ointments can be absorbed into the implant’s material, causing it to swell and sometimes break. Patient cases showed damage only when the implant directly contacted the ointment, a result confirmed in lab experiments. The findings raise concerns about standard post-surgery eye care.

Scientists have discovered that the adolescent brain does more than prune old connections. During the teen years, it actively builds dense new clusters of synapses in specific parts of neurons. These clusters emerge only in adolescence and may help shape higher-level thinking. When the process is disrupted, it could play a role in conditions like schizophrenia.

A vitamin A byproduct has been found to quietly disarm the immune system, allowing tumors to evade attack and weakening cancer vaccines. Scientists have now developed a drug that shuts down this pathway, dramatically boosting immune responses and slowing cancer growth in preclinical studies.

Researchers have identified OTULIN, an immune-regulating enzyme, as a key trigger of tau buildup in the brain. When OTULIN was disabled, tau vanished from neurons and brain cells remained healthy. The findings challenge long-held assumptions about tau’s necessity and highlight a promising new path for fighting Alzheimer’s and brain aging. Scientists now believe OTULIN may act as a master switch for inflammation and age-related brain decline.

Tryptophan does far more than help us sleep—it fuels brain chemistry, energy production, and mood-regulating neurotransmitters. But as the brain ages or develops neurological disease, this delicate system goes awry, pushing tryptophan toward harmful byproducts linked to memory loss, mood changes, and sleep problems.

New research suggests statins may protect adults with type 2 diabetes regardless of how low their predicted heart risk appears. In a large UK study, statin use was linked to fewer deaths and major cardiac events across all risk levels. Even those labeled “low risk” benefited, challenging long-held assumptions about who should receive preventive therapy. Side effects were rare and generally mild.

Spikes in blood sugar after eating may be more dangerous for the brain than previously thought. In a massive genetic study, people with higher post-meal blood sugar had a much greater risk of Alzheimer’s disease. The effect couldn’t be explained by visible brain damage, suggesting hidden biological pathways may be involved. Researchers say managing blood sugar after meals could become a key strategy for reducing dementia risk.

“BPA-free” food packaging may be hiding new risks. A McGill University study found that several BPA substitutes used in grocery price labels can seep into food and interfere with vital processes in human ovarian cells. Some triggered unusual fat buildup and disrupted genes linked to cell repair and growth. The results raise concerns that BPA replacements may be just as troubling as the chemical they replaced.

Pancreatic cancer uses a sugar-coated disguise to evade the immune system, helping explain why it’s so hard to treat. Northwestern scientists discovered this hidden mechanism and created an antibody that strips away the tumor’s protective signal. In animal tests, immune cells sprang back into action and tumors grew much more slowly. The team is now refining the therapy for future human trials.

Researchers have discovered a rare new type of diabetes that affects babies early in life. The condition is caused by changes in a single gene that prevent insulin-producing cells from working properly. When these cells fail, blood sugar rises and diabetes develops, often alongside neurological problems. The findings help explain a long-standing medical mystery and deepen understanding of diabetes overall.

A new discovery may explain why so many people abandon cholesterol-lowering statins because of muscle pain and weakness. Researchers found that certain statins can latch onto a key muscle protein and trigger a tiny but harmful calcium leak inside muscle cells. That leak may weaken muscles directly or activate processes that slowly break them down, offering a long-sought explanation for statin-related aches.

Scientists are taking a closer look at monk fruit and discovering it’s more than just a sugar substitute. New research shows its peel and pulp contain a rich mix of antioxidants and bioactive compounds that may support health. Different varieties offer different chemical profiles, hinting at unique benefits. The work could shape how monk fruit is used in future foods and supplements.

A massive international brain study has revealed that memory decline with age isn’t driven by a single brain region or gene, but by widespread structural changes across the brain that build up over time. Analyzing thousands of MRI scans and memory tests from healthy adults, researchers found that memory loss accelerates as brain tissue shrinkage increases, especially later in life. While the hippocampus plays a key role, many other brain regions also contribute, forming a broad vulnerability rather than isolated damage.

A new study reveals that alpha brain waves help the brain decide what belongs to your body. Faster rhythms allow the brain to match sight and touch more precisely, strengthening the feeling that a body part is truly yours. Slower rhythms blur that timing, making it harder to separate self from surroundings. The findings could improve prosthetic design and immersive virtual experiences.

Some people get drunk without drinking because their gut bacteria produce alcohol from food. Researchers have now identified the microbes and biological pathways behind this rare condition, auto-brewery syndrome. Tests showed patients’ gut samples produced far more alcohol than those of healthy people. In one case, a fecal transplant led to long-lasting symptom relief.

Despite longstanding guidelines, many dementia patients are still prescribed brain-altering medications that can raise the risk of falls and confusion. A new study shows that while prescribing has decreased overall, people with cognitive impairment remain more likely to receive these drugs. In many cases, there was no documented medical justification. The results suggest that medication safety remains a serious concern in dementia care.

A generative AI system can now analyze blood cells with greater accuracy and confidence than human experts, detecting subtle signs of diseases like leukemia. It not only spots rare abnormalities but also recognizes its own uncertainty, making it a powerful support tool for clinicians.

Childbirth depends not just on hormones, but on the uterus’s ability to sense physical force. Scientists found that pressure and stretch sensors in uterine muscles and surrounding nerves work together to trigger coordinated contractions. When these sensors are disrupted, contractions weaken and delivery slows. The discovery helps explain stalled labor—and could one day lead to better ways to manage childbirth.

Scientists at Tufts have found a way to turn common glucose into a rare sugar that tastes almost exactly like table sugar—but with far fewer downsides. Using engineered bacteria as microscopic factories, the team can now produce tagatose efficiently and cheaply, achieving yields far higher than current methods. Tagatose delivers nearly the same sweetness as sugar with significantly fewer calories, minimal impact on blood sugar, and even potential benefits for oral and gut health.

MIT engineers have developed a pill that can wirelessly report when it’s been swallowed. Inside the capsule is a biodegradable antenna that sends a signal within minutes of ingestion, then safely dissolves. The system is designed to work with existing medications and could help doctors track adherence for high-risk patients. Researchers hope it will prevent missed doses that can lead to serious health consequences.

Some antibiotics stop bacteria from growing without actually killing them, allowing infections to return later. Scientists at the University of Basel created a new test that tracks individual bacteria to see which drugs truly eliminate them. When tested on tuberculosis and other serious lung infections, the method revealed big differences in how bacteria tolerate treatment. The findings could lead to more precise therapies and better predictions of treatment success.

Waiting to eat when your food arrives first feels polite—but it may be mostly for your own peace of mind. Researchers found people feel far more uncomfortable breaking the “wait until everyone is served” rule than they expect others would feel watching it happen. Even being told to go ahead doesn’t fully ease the discomfort. Serving everyone at once could reduce awkwardness and make meals more enjoyable.

Researchers have discovered a brain activity pattern that can predict which people with mild cognitive impairment are likely to develop Alzheimer’s disease. Using a noninvasive brain scanning technique and a custom analysis tool, they detected subtle changes in electrical signals tied to memory processing years before diagnosis. The findings point to a new way of spotting Alzheimer’s early—by listening directly to how neurons behave.

A small group of people experience no pleasure from music despite normal hearing and intact emotions. Brain imaging reveals that their auditory and reward systems fail to properly communicate, leaving music emotionally flat. Researchers developed a questionnaire to measure how rewarding music feels across emotions, mood, movement, and social connection. The findings suggest pleasure isn’t all-or-nothing and may depend on how specific brain networks connect.

Weight-loss drugs like Ozempic and Wegovy are changing how Americans spend money on food. A large Cornell study found households cut grocery spending by over 5% within six months, with even bigger drops at fast-food restaurants. Snack foods and sweets saw the steepest declines, while only a few categories like yogurt and fruit rose slightly. The effects linger for at least a year among continued users.