Medical and Health Sciences

People who naturally stay up late may be putting their hearts under added strain as they age. A large study tracking more than 300,000 adults found that middle-aged and older night owls had poorer overall heart health and a higher risk of heart attack and stroke than those who were active earlier in the day, with the effect especially pronounced in women. Much of this elevated risk appeared to stem from lifestyle factors common among evening types, including smoking and inadequate sleep.

Men start developing heart disease earlier than women, with risks rising faster beginning around age 35, according to long-term research. The difference is driven mainly by coronary heart disease, not stroke or heart failure. Traditional risk factors explain only part of the gap. The findings suggest earlier screening could help catch problems before serious damage occurs.

A new drug developed by Australian researchers has shown promising results in reducing sepsis in a Phase II clinical trial involving 180 patients. The carbohydrate-based treatment works by calming a dangerous immune reaction that can cause organ failure. With no specific anti-sepsis therapy currently available, the findings mark a major step forward. Researchers now aim to move into Phase III trials.

Researchers have discovered how pancreatic cancer reprograms its surroundings to spread quickly and stealthily. By using a protein called periostin, the tumor remodels nearby tissue and invades nerves, which helps cancer cells travel and form metastases. This process also creates a tough, fibrous barrier that makes treatments less effective. Targeting periostin could help stop this invasion before it starts.

A fast-aging fish is giving scientists a rare, accelerated look at how kidneys grow old—and how a common drug may slow that process down. Researchers found that SGLT2 inhibitors, widely used to treat diabetes and heart disease, preserved kidney structure, blood vessels, and energy production as the fish aged, while also calming inflammation. The results help explain why these drugs protect kidneys and hearts so reliably in people, even beyond blood sugar control.

A new imaging technology called fast-RSOM lets researchers see the smallest blood vessels in the body without invasive procedures. It can detect early dysfunction in these vessels — a quiet warning sign of future heart disease — long before symptoms appear. Unlike traditional risk estimates, it measures real changes happening in the body. The portable system could one day be used in routine checkups to catch heart risks earlier.

Two decades after a breast cancer vaccine trial, every participant is still alive—an astonishing result for metastatic disease. Scientists found their immune systems retained long-lasting memory cells primed to recognize cancer. By enhancing a key immune signal called CD27, researchers dramatically improved tumor elimination in lab studies. The findings suggest cancer vaccines may have been missing a crucial ingredient all along.

Scientists at Mount Sinai have unveiled a bold new way to fight metastatic cancer by turning the tumor’s own defenses against it. Instead of attacking cancer cells head-on, the experimental immunotherapy targets macrophages—immune cells that tumors hijack to shield themselves from attack. By eliminating or reprogramming these “bodyguards,” the treatment cracks open the tumor’s protective barrier and allows the immune system to flood in and destroy the cancer.

Collagen pills sound like a shortcut to younger skin, but solid evidence doesn’t back them up. Higher-quality studies show little benefit, and your body doesn’t absorb collagen in the way ads suggest. Some supplements may even pose safety concerns and lack proper testing. Experts recommend focusing on proven habits like sunscreen, retinoids, and a nutrient-rich diet instead.

An experimental drug once known for helping control type 2 diabetes may also fight heart disease. Researchers found IC7Fc lowered cholesterol, blood fats, and artery-clogging plaques while calming inflammation linked to heart attacks and strokes. Notably, these benefits appeared even without weight loss, suggesting the drug could help lean people at risk of heart disease.

Scientists in Sweden and Norway have uncovered a promising way to spot Parkinson’s disease years—possibly decades—before its most damaging symptoms appear. By detecting subtle biological signals in the blood tied to how cells handle stress and repair DNA, the team identified a brief early window when Parkinson’s quietly leaves a measurable fingerprint.

Helping care for grandchildren may offer an unexpected boost to brain health later in life. Researchers found that grandparents who provided childcare scored higher on memory and verbal skills than those who did not. The effect did not depend on how often they helped or the type of care they provided. Being involved as a caregiver itself appeared to matter most.

Drinking heavily over many years is linked to a higher risk of colorectal cancer, especially rectal cancer, according to new research tracking U.S. adults for two decades. People who drank heavily throughout adulthood faced sharply higher risks than light drinkers. Former drinkers did not show increased cancer risk and had fewer precancerous tumors. The results suggest that quitting alcohol may help lower long-term cancer risk.

Scientists at KAIST have found a way to turn a tumor’s own immune cells into powerful cancer fighters—right inside the body. Tumors are packed with macrophages, immune cells that should attack cancer but are usually silenced by the tumor environment. By injecting a specially designed drug directly into tumors, researchers were able to “reprogram” these dormant cells to recognize and destroy cancer.

Researchers have developed smart nanoparticles that can seek out and destroy disease-causing proteins the body can’t normally eliminate. Unlike traditional drugs, these particles can reach hard-to-access tissues, including the brain, and precisely target problem proteins without widespread side effects. Early results show promise against major cancer drivers, and the platform is designed to be easily adapted to many diseases. The work could reshape the future of precision medicine.

Cancer immunotherapy has been a game-changer, but many tumors still find ways to slip past the immune system. New research reveals a hidden trick: cancer cells can package the immune-blocking protein PD-L1 into tiny particles that circulate through the body and weaken immunotherapy’s impact. Scientists in Japan discovered that a little-known protein, UBL3, controls this process—and surprisingly, common cholesterol-lowering drugs called statins can shut it down.

A massive international study of more than 3,100 long COVID patients uncovered a striking divide in how brain-related symptoms are reported around the world. In the U.S., the vast majority of non-hospitalized patients described brain fog, depression, and anxiety, while far fewer patients in countries like India and Nigeria reported the same issues. The difference doesn’t appear to be about the virus itself, but about culture, stigma, and access to mental health care.

Ozempic, Mounjaro, and Zepbound can drive impressive weight loss, but stopping them is often followed by rapid weight regain. Researchers found that people regain weight faster after quitting these drugs than after diet and exercise alone. Improvements in heart health and diabetes risk also tend to reverse within a few years. The results suggest long-term success may require more than medication alone.

Scientists in South Korea have discovered that one of the most common malignant brain tumors in young adults may begin years before a tumor can be seen. IDH-mutant glioma, long treated by removing visible tumor tissue, actually starts when normal-looking brain cells quietly acquire a cancer-linked mutation and spread through the brain’s cortex. Using advanced genetic mapping and animal models, researchers traced the cancer’s true origin to glial progenitor cells that appear healthy at first.

Where your body stores fat may matter just as much as how much you carry—especially for your brain. Using advanced MRI scans and data from nearly 26,000 people, researchers identified two surprising fat patterns tied to faster brain aging, cognitive decline, and higher neurological disease risk. One involves unusually high fat buildup in the pancreas, even without much liver fat, while the other—often called “skinny fat”—affects people who don’t appear severely obese but carry excess fat relative to muscle.

Drinking tea, particularly green tea, is linked to better heart health, improved metabolism, and lower risks of chronic diseases like diabetes and cancer. It may also help protect the brain and preserve muscle strength as people age. However, processed teas—such as bottled and bubble varieties—often contain sugars and additives that may cancel out these benefits. Moderation and choosing freshly brewed tea appear key.

AI may learn better when it’s allowed to talk to itself. Researchers showed that internal “mumbling,” combined with short-term memory, helps AI adapt to new tasks, switch goals, and handle complex challenges more easily. This approach boosts learning efficiency while using far less training data. It could pave the way for more flexible, human-like AI systems.

A sweeping scientific review highlights wild blueberries as a standout food for cardiometabolic health. The strongest evidence shows improvements in blood vessel function, with encouraging signs for blood pressure, cholesterol, blood sugar, gut health, and cognition. Researchers suggest these benefits may kick in within hours—or build over weeks—thanks to the berries’ unique mix of polyphenols and fiber.

A common parasite long thought to lie dormant is actually much more active and complex. Researchers found that Toxoplasma gondii cysts contain multiple parasite subtypes, not just one sleeping form. Some are primed to reactivate and cause disease, which helps explain why infections are so hard to treat. The discovery could reshape efforts to develop drugs that finally eliminate the parasite for good.

Researchers have discovered a biological switch that explains why movement keeps bones strong. The protein senses physical activity and pushes bone marrow stem cells to build bone instead of storing fat, slowing age-related bone loss. By targeting this “exercise sensor,” scientists believe they could create drugs that mimic exercise at the molecular level. The approach could protect fragile bones in people who are unable to stay active.

Asthma may not be driven by the molecules scientists have blamed for decades. Researchers have identified “pseudo leukotrienes,” inflammation-triggering compounds formed by uncontrolled free-radical reactions rather than normal enzymes. These molecules were found at much higher levels in people with asthma, closely tracking how severe their symptoms were. The finding hints at a new way to treat asthma by preventing the inflammatory spark instead of blocking its aftermath.

A long-term study found that while a ketogenic diet prevented weight gain, it also triggered major metabolic problems. Mice developed fatty liver disease, abnormal blood fats, and an impaired ability to control blood sugar—especially after reintroducing carbohydrates. Male mice were hit hardest, showing severe liver damage. The results suggest keto’s benefits may come with hidden risks over time.

Findings could create new opportunities to treat and study neurodegenerative diseasesScientists discovered that sugar metabolism plays a surprising role in whether injured neurons collapse or cling to life. By activating internal protective programs, certain metabolic changes can temporarily slow neurodegeneration—hinting at new ways to help the brain defend itself.

A large French study tracking more than 100,000 people over a decade has found that higher consumption of certain food preservatives—commonly found in processed foods and drinks—is linked to a modestly higher cancer risk. While many preservatives showed no association, several widely used ones, including potassium sorbate, sulfites, sodium nitrite, and potassium nitrate, were tied to increased risks of overall cancer and specific types such as breast and prostate cancer.

Carbohydrates don’t just fuel the body—they may also influence how the brain ages. A large long-term study found that diets high in fast-acting carbs that rapidly raise blood sugar were linked to a higher risk of dementia. People who ate more low-glycemic foods like fruit, legumes, and whole grains had a noticeably lower risk of Alzheimer’s. The quality of carbs, not just the amount, appears to matter for brain health.

A new genetic study suggests that obesity and high blood pressure may play a direct role in causing dementia, not just increasing the risk. By analyzing data from large populations in Denmark and the U.K., researchers found strong evidence that higher body weight can damage brain health over time, especially when it leads to elevated blood pressure. Much of the dementia risk appeared to be tied to vascular damage in the brain, which affects blood flow and cognitive function.

Home fireplaces and wood stoves are quietly driving a large share of winter air pollution, even though only a small number of households rely on wood heat. Researchers found that wood smoke accounts for over one-fifth of Americans’ winter exposure to dangerous fine particles linked to heart disease and early death. Much of this pollution drifts into cities, where it disproportionately harms people of color. Reducing wood burning could deliver major public health benefits.

A 5,500-year-old skeleton from Colombia has revealed the oldest known genome of the bacterium linked to syphilis and related diseases. The ancient strain doesn’t fit neatly into modern categories, hinting at a forgotten form that split off early in the pathogen’s evolution. This pushes the history of treponemal diseases in the Americas back by millennia and shows they were already diversifying long before written records.

Cancer doesn’t evolve by pure chaos. Scientists have developed a powerful new method that reveals the hidden rules guiding how cancer cells gain and lose whole chromosomes—massive genetic shifts that help tumors grow, adapt, and survive treatment. By tracking thousands of individual cells over time, the approach shows which chromosome combinations give cancer an edge and why some tumors become especially resilient.

Alzheimer’s may destroy memory by flipping a single molecular switch that tells neurons to prune their own connections. Researchers found that both amyloid beta and inflammation converge on the same receptor, triggering synapse loss. Surprisingly, neurons aren’t passive victims—they actively respond to these signals. Targeting this receptor could offer a new way to protect memory beyond current amyloid-focused drugs.

A newly uncovered immune chain reaction in the gut may explain why people with inflammatory bowel disease face a much higher risk of colorectal cancer. Researchers found that a powerful inflammatory signal flips on specialized gut immune cells, which then call in waves of white blood cells from the bone marrow and rewire them in ways that help tumors grow. This process appears to damage DNA in the gut lining and create a tumor-friendly environment.

A massive new study comparing more than 100,000 people with today’s most advanced AI systems delivers a surprising result: generative AI can now beat the average human on certain creativity tests. Models like GPT-4 showed strong performance on tasks designed to measure original thinking and idea generation, sometimes outperforming typical human responses. But there’s a clear ceiling. The most creative humans — especially the top 10% — still leave AI well behind, particularly on richer creative work like poetry and storytelling.

Scientists are warning that a little-known group of microbes called free-living amoebae may pose a growing global health threat. Found in soil and water, some species can survive extreme heat, chlorine, and even modern water systems—conditions that kill most germs. One infamous example, the “brain-eating amoeba,” can cause deadly infections after contaminated water enters the nose. Even more concerning, these amoebae can act as hiding places for dangerous bacteria and viruses, helping them evade disinfection and spread.

Researchers have found that a natural aging-related molecule can repair key memory processes affected by Alzheimer’s disease. The compound improves communication between brain cells and restores early memory abilities that typically fade first. Because it already exists in the body and declines with age, boosting it may offer a safer way to protect the brain. The discovery hints at a new strategy for slowing cognitive ageing before severe damage sets in.

Chronic inflammation may be quietly reshaping the colon and making it more vulnerable to early-onset colorectal cancer. Scientists found that colon tissue in younger patients was stiffer, even in areas that appeared healthy, suggesting these changes may happen before cancer develops. Lab experiments showed that cancer cells grow faster in rigid environments.

Aging immune cells may be sabotaging the body from within. Researchers found that macrophages produce a protein that locks them into a chronic inflammatory state, making infections like sepsis more deadly in older adults. Turning off this signal reduced inflammation and improved survival in older models. The findings hint at future treatments that could dial back harmful immune overreactions.

People with spinal cord injuries often lose movement even though their brains still send the right signals. Researchers tested whether EEG brain scans could capture those signals and reroute them to spinal stimulators. The system can detect when a patient is trying to move, though finer control remains a challenge. Scientists hope future improvements could turn intention into action.

A large, decades-long study suggests that signs of ADHD in childhood may have consequences that extend well beyond school and behavior. Researchers followed nearly 11,000 people from childhood into midlife and found that those with strong ADHD traits at age 10 were more likely to experience multiple physical health problems and health-related disability by their mid-40s.

Pancreatic cancer may evade the immune system using a clever molecular trick. Researchers found that the cancer-driving protein MYC also suppresses immune alarm signals, allowing tumors to grow unnoticed. When this immune-shielding ability was disabled in animal models, tumors rapidly collapsed. The findings point to a new way to expose cancer to the body’s own defenses without harming healthy cells.

Chemotherapy’s gut damage turns out to have a surprising upside. By changing nutrient availability in the intestine, it alters gut bacteria and increases levels of a microbial molecule that travels to the bone marrow. This signal reshapes immune cell production, strengthening anti-cancer defenses and making metastatic sites harder for tumors to colonize. Patient data suggest this immune rewiring is linked to better survival.

Alzheimer’s may be driven far more by genetics than previously thought, with one gene playing an outsized role. Researchers found that up to nine in ten cases could be linked to the APOE gene — even including a common version once considered neutral. The discovery reshapes how scientists think about risk and prevention. It also highlights a major opportunity for new treatments aimed at a single biological pathway.

In Guatemala’s Western Highlands, researchers found that the drinking water people trust most may actually be the riskiest. Bottled water from refillable jugs—seen as the safest choice—was frequently contaminated with harmful bacteria, while protected municipal wells were the cleanest.

New research suggests that auditory hallucinations in schizophrenia may come from a brain glitch that confuses inner thoughts for external voices. Normally, the brain predicts the sound of its own inner speech and tones down its response. But in people hearing voices, brain activity ramps up instead, as if the voice belongs to someone else. The discovery could help scientists develop early warning signs for psychosis.

Researchers have identified a promising new weapon against triple-negative breast cancer, one of the most aggressive forms of the disease. An experimental antibody targets a protein that fuels tumor growth and shuts down immune defenses, effectively turning the immune system back on. In early tests, the treatment slowed tumor growth, reduced lung metastases, and destroyed chemotherapy-resistant cancer cells.

Type 2 diabetes becomes more dangerous to the heart the longer a person has it. Researchers found that after several years, red blood cells can begin interfering with healthy blood vessel function. This harmful shift was not present in newly diagnosed patients but emerged over time. A small molecule inside blood cells may help flag rising cardiovascular risk early.

A new study reveals that super agers over 80 have a distinct genetic edge. They are much less likely to carry the gene most associated with Alzheimer’s risk, even when compared with other healthy seniors. Researchers also found higher levels of a protective gene variant in this group. Together, the findings help explain why some people age with remarkably youthful minds.

A new blood test may reveal Crohn’s disease years before symptoms begin. The test detects an unusual immune response to gut bacteria in people who later develop the condition. By studying healthy relatives of Crohn’s patients, researchers identified early warning signals long in advance. The findings raise hope for earlier diagnosis and future prevention.

Scientists found that nasal cells act as a first line of defense against the common cold, working together to block rhinovirus soon after infection. A fast antiviral response can stop the virus before symptoms appear. If that response is weakened or delayed, the virus spreads and causes inflammation and breathing problems. The study highlights why the body’s reaction matters more than the virus alone.

Scientists studying genetic data from over a quarter million people have uncovered new clues about what controls how fast the gut moves. They identified multiple DNA regions linked to bowel movement frequency, confirming known gut pathways and revealing new ones. The biggest surprise was a strong connection to vitamin B1, a common nutrient not usually linked to digestion.

Fungal infections are becoming deadlier as drug resistance spreads and treatment options stall. Researchers at McMaster University discovered that a molecule called butyrolactol A can dramatically weaken dangerous fungi, allowing existing antifungal drugs to work again. Instead of killing the fungus directly, the molecule sabotages a vital internal system, leaving the pathogen exposed. The breakthrough could help revive an entire class of antifungal medicines once thought obsolete.

New research suggests that consistent aerobic exercise can help keep your brain biologically younger. Adults who exercised regularly for a year showed brains that appeared nearly a year younger than those who didn’t change their habits. The study focused on midlife, a critical window when prevention may offer long-term benefits. Even small shifts in brain age could add up over decades.

A major global study suggests that a hidden mismatch between two common blood tests could quietly signal serious trouble ahead. When results from creatinine and cystatin C—two markers used to assess kidney health—don’t line up, the risk of kidney failure, heart disease, and even death appears to rise sharply. Researchers found that this gap is especially common among hospitalized and older patients, and that relying on just one test may miss early warning signs.

Researchers from New England Biolabs (NEB®) and Yale University describe the first fully synthetic bacteriophage engineering system for Pseudomonas aeruginosa, an antibiotic-resistant bacterium of global concern, in a new PNAS study. The system is enabled by NEB’s High-Complexity Golden Gate Assembly (HC-GGA) platform. In this method, researchers engineer bacteriophages synthetically using sequence data rather than bacteriophage isolates.

Scientists have uncovered why people with chronic kidney disease so often die from heart problems: damaged kidneys release tiny particles into the bloodstream that actively poison the heart. These particles, produced only by diseased kidneys, carry genetic material that disrupts heart function and can lead to heart failure.

Researchers have identified a key molecular interaction that accelerates Parkinson’s disease by damaging the brain’s energy systems. They designed a new treatment that intercepts this harmful process, protecting brain cells and restoring their function. In lab and animal models, the approach improved movement and cognitive performance while reducing inflammation. The findings point toward a new generation of Parkinson’s therapies aimed at the root cause, not just the symptoms.