Medical and Health Sciences

A high-fat diet does more than overload the liver with fat. New research from MIT shows that prolonged exposure to fatty foods can push liver cells into a survival mode that quietly raises the risk of cancer. Faced with ongoing metabolic stress, these cells abandon their normal roles and revert to a more primitive state that helps them endure harsh conditions. Over time, that shift leaves the liver less functional and far more vulnerable to tumor formation, helping explain why fatty liver disease so often precedes liver cancer.

A major update to how obesity is defined could push U.S. obesity rates to nearly 70%, according to a large new study. The change comes from adding waist and body fat measurements to BMI, capturing people who were previously considered healthy. Many of these newly included individuals face higher risks of diabetes and heart disease. The findings suggest that where fat is stored may be just as important as overall weight.

New research reveals a brighter side of ADHD, showing that adults who recognize and use their strengths feel happier, healthier, and less stressed. People with ADHD were more likely to identify traits like creativity, humor, and hyperfocus as personal strengths. Across the board, using these strengths was linked to better quality of life and fewer mental health symptoms. The study suggests that embracing strengths could be a game-changer for ADHD support.

Microplastics in rivers, lakes, and oceans aren’t just drifting debris—they’re constantly leaking invisible clouds of chemicals into the water. New research shows that sunlight drives this process, causing different plastics to release distinct and evolving mixtures of dissolved organic compounds as they weather. These chemical plumes are surprisingly complex, often richer and more biologically active than natural organic matter, and include additives, broken polymer fragments, and oxidized molecules.

New research suggests that even light alcohol use may carry serious risks. A large study in India found that drinking just one standard drink a day is linked to a roughly 50% higher risk of mouth cancer, with the greatest danger tied to locally brewed alcohol. When alcohol use overlaps with chewing tobacco, the effect becomes especially severe, potentially explaining nearly two-thirds of all cases nationwide.

Cannabis products with higher THC levels may slightly reduce chronic pain, particularly nerve pain, according to a review of multiple clinical trials. The improvement was small and short-lived, while side effects were more common. Products with little or no THC, including CBD-only formulations, showed no clear benefit. Researchers say more long-term studies are needed.

Letting a swear word fly when you’re struggling might do more than blow off steam—it could actually make you stronger. Research published by the American Psychological Association found that people who swear during physical challenges can push themselves harder and last longer. The boost seems to come from swearing’s ability to lower inhibitions, increase confidence, and help people slip into a focused “flow” state.

New research shows that women living near Superfund sites are more likely to develop aggressive and metastatic breast cancers. The studies found higher risks for hard-to-treat subtypes like triple-negative breast cancer, especially in areas with greater air pollution. Scientists also discovered molecular tumor changes linked to neighborhood deprivation. The findings point to environmental exposure and social conditions as key factors shaping cancer outcomes.

As the immune system weakens with age, scientists have found a way to restore some of its lost strength. By delivering mRNA to the liver, they created a temporary source of immune-boosting signals that normally come from the thymus. Older mice treated this way produced more effective T cells and responded far better to vaccines and cancer treatments. The strategy could one day help extend healthy years of life.

Researchers have created a protein that can detect the faint chemical signals neurons receive from other brain cells. By tracking glutamate in real time, scientists can finally see how neurons process incoming information before sending signals onward. This reveals a missing layer of brain communication that has been invisible until now. The discovery could reshape how scientists study learning, memory, and brain disease.

After the January 2025 LA wildfires, hospitals recorded a surge in serious health problems. Emergency visits for heart attacks, lung illness, and general sickness rose sharply in the following three months. Researchers believe fine particles from wildfire smoke, along with stress, may have triggered these effects. Unusual blood test changes point to hidden health impacts that lingered well beyond the fires themselves.

Tiny lab-grown brains are offering an unprecedented look at how schizophrenia and bipolar disorder disrupt neural activity. Researchers found distinct electrical firing patterns that could identify these conditions with high accuracy. The discovery opens the door to more precise diagnoses and personalized drug testing. Instead of guessing medications, doctors may one day see what works before treating the patient.

Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. In mid-aged animals, slimming down actually worsened inflammation in a brain region tied to appetite and energy balance. While this inflammation eventually subsided, brain inflammation has been linked to cognitive decline and neurodegenerative disease. The results suggest that weight loss in midlife may not be as straightforward as once thought.

A randomized trial from Vanderbilt-Ingram Cancer Center reveals that magnesium may be the missing key to keeping vitamin D levels in balance. The study found that magnesium raised vitamin D in people who were deficient while dialing it down in those with overly high levels—suggesting a powerful regulating effect. This could help explain why vitamin D supplements don’t work the same way for everyone and why past studies linking vitamin D to cancer and heart disease have produced mixed results.

A major new review has put hundreds of alternative autism treatments under the microscope—and most didn’t hold up. Scientists analyzed decades of research and found little reliable evidence that popular approaches like probiotics, acupuncture, or music therapy truly work. Alarmingly, safety was often ignored, with many treatments never properly evaluated for side effects. The researchers stress that looking at the full body of evidence matters far more than trusting a single hopeful study.

Stanford scientists have uncovered how mRNA COVID-19 vaccines can very rarely trigger heart inflammation in young men — and how that risk might be reduced. They found that the vaccines can spark a two-step immune reaction that floods the body with inflammatory signals, drawing aggressive immune cells into the heart and causing temporary injury.

UBC Okanagan researchers have uncovered how plants create mitraphylline, a rare natural compound linked to anti-cancer effects. By identifying two key enzymes that shape and twist molecules into their final form, the team solved a puzzle that had stumped scientists for years. The discovery could make it far easier to produce mitraphylline and related compounds sustainably. It also highlights plants as master chemists with untapped medical potential.

Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic tangles overwhelm normal repair pathways, cells flip on a fast but error-prone emergency fix that helps them survive. Some cancer cells rely heavily on this backup system, even though it makes their DNA more unstable. Blocking this process could expose a powerful new way to target tumors.

Vitamin C doesn’t just belong in skincare products—it works even better when you eat it. Scientists discovered that vitamin C from food travels through the bloodstream into every layer of the skin, boosting collagen and skin renewal. People who ate two vitamin C–packed kiwifruit daily showed thicker, healthier skin. The findings suggest glowing skin really does start from within.

Everyday sights and sounds quietly shape the choices people make, often without them realizing it. New research suggests that some individuals become especially influenced by these environmental cues, relying on them heavily when deciding what to do. The problem arises when those cues start leading to worse outcomes. For certain people, the brain struggles to update these learned signals, causing them to repeat risky or harmful decisions over time.

Scientists discovered that common food emulsifiers consumed by mother mice altered their offspring’s gut microbiome from the very first weeks of life. These changes interfered with normal immune system training, leading to long-term inflammation. As adults, the offspring were more vulnerable to gut disorders and obesity. The findings suggest that food additives may have hidden, lasting effects beyond those who consume them directly.

ADHD stimulants appear to work less by sharpening focus and more by waking up the brain. Brain scans revealed that these medications activate reward and alertness systems, helping children stay interested in tasks they would normally avoid. The drugs even reversed brain patterns linked to sleep deprivation. Researchers say this could complicate ADHD diagnoses if poor sleep is the real underlying problem.

A new study suggests temporal lobe epilepsy may be linked to early aging of certain brain cells. When researchers removed these aging cells in mice, seizures dropped, memory improved, and some animals avoided epilepsy altogether. The treatment used drugs already known to science, raising the possibility of quicker translation to people. The results offer new hope for patients who do not respond to existing medications.

Tramadol, a popular opioid often seen as a “safer” painkiller, may not live up to its reputation. A large analysis of clinical trials found that while it does reduce chronic pain, the relief is modest—so small that many patients likely wouldn’t notice much real-world benefit. At the same time, tramadol was linked to a significantly higher risk of serious side effects, especially heart-related problems like chest pain and heart failure, along with common issues such as nausea, dizziness, and sleepiness.

A new study suggests that dementia may be driven in part by faulty blood flow in the brain. Researchers found that losing a key lipid causes blood vessels to become overactive, disrupting circulation and starving brain tissue. When the missing molecule was restored, normal blood flow returned. This discovery opens the door to new treatments aimed at fixing vascular problems in dementia.

Alzheimer’s has long been considered irreversible, but new research challenges that assumption. Scientists discovered that severe drops in the brain’s energy supply help drive the disease—and restoring that balance can reverse damage, even in advanced cases. In mouse models, treatment repaired brain pathology, restored cognitive function, and normalized Alzheimer’s biomarkers. The results offer fresh hope that recovery may be possible.

The familiar fight between “mind as software” and “mind as biology” may be a false choice. This work proposes biological computationalism: the idea that brains compute, but not in the abstract, symbol-shuffling way we usually imagine. Instead, computation is inseparable from the brain’s physical structure, energy constraints, and continuous dynamics. That reframes consciousness as something that emerges from a special kind of computing matter, not from running the right program.

A four–amino acid peptide called CAQK has shown powerful brain-protective effects in animal models of traumatic brain injury. Delivered through a standard IV, it zeroes in on injured brain tissue, calming inflammation and reducing cell death while improving recovery. The peptide worked in both mice and pigs, whose brains are closer to humans in structure. Researchers are now preparing to move toward early human clinical trials.

Researchers have created tiny metal-based particles that push cancer cells over the edge while leaving healthy cells mostly unharmed. The particles work by increasing internal stress in cancer cells until they trigger their own shutdown process. In lab tests, they killed cancer cells far more effectively than healthy ones. The technology is still early-stage, but it opens the door to more precise and gentler cancer treatments.

Scientists studying thousands of rats discovered that gut bacteria are shaped by both personal genetics and the genetics of social partners. Some genes promote certain microbes that can spread between individuals living together. When researchers accounted for this social sharing, genetic influence on the microbiome turned out to be much stronger than previously thought. The study suggests genes can affect others indirectly, without DNA ever being exchanged.

Scientists at MIT and Stanford have unveiled a promising new way to help the immune system recognize and attack cancer cells more effectively. Their strategy targets a hidden “off switch” that tumors use to stay invisible to immune defenses—special sugar molecules on the cancer cell surface that suppress immune activity. Early tests show it can supercharge immune responses and outperform current antibody therapies.

A deadly hospital fungus that resists nearly every antifungal drug may have an unexpected weakness. Researchers discovered that Candida auris activates specific genes during infection to hunt for nutrients it needs to survive. This insight came from a new living-host model that allowed scientists to watch the fungus in action. The findings could eventually lead to new treatments or allow current drugs to be repurposed.

A new imaging technology can distinguish cancerous tissue from healthy cells by detecting ultra-weak light signals. It relies on nanoparticles that bind to tumor markers, making cancerous areas easier to identify. The system is far more sensitive than existing tools and could speed up cancer screening. Scientists believe it may help detect tumors earlier and reduce delays in diagnosis.

When we watch someone move, get injured, or express emotion, our brain doesn’t just see it—it partially feels it. Researchers found eight body-like maps in the visual cortex that organize what we see in the same way the brain organizes touch. These maps help us instantly understand actions, emotions, and intentions in others. The discovery sheds light on human empathy and opens doors for new brain-based therapies and AI systems that better understand the body.

Your eyes may reveal when your brain is working overtime. Researchers found that people blink less when trying to understand speech in noisy environments, especially during the most important moments. The effect stayed the same in bright or dark rooms, showing it’s driven by mental effort, not light. Blinking, it turns out, is a quiet marker of focused listening.

MIT scientists have achieved the first-ever lab synthesis of verticillin A, a complex fungal compound discovered in 1970. Its delicate structure stalled chemists for decades, despite differing from related molecules by only two atoms. With the synthesis finally complete, researchers created new variants that showed strong activity against a rare pediatric brain cancer. The breakthrough could unlock an entire class of previously unreachable cancer-fighting molecules.

New research suggests Alzheimer’s may start far earlier than previously thought, driven by a hidden toxic protein in the brain. Scientists found that an experimental drug, NU-9, blocks this early damage in mice and reduces inflammation linked to disease progression. The treatment was given before symptoms appeared, targeting the disease at its earliest stage. Researchers say this approach could reshape how Alzheimer’s is prevented and treated.

How you walk may matter just as much as how much you walk. A large UK study tracking more than 33,000 low-activity adults found that people who grouped their daily steps into longer, uninterrupted walks had dramatically lower risks of early death and heart disease than those who moved in short, scattered bursts.

A new study shows dopamine isn’t the brain’s movement “gas pedal” after all. Instead of setting speed or strength, it quietly enables movement in the background, much like oil in an engine. When scientists manipulated dopamine during movement, nothing changed—but restoring baseline dopamine levels made a big difference. The finding could reshape how Parkinson’s disease is treated.

A Brazilian study has confirmed that Joseph’s Coat, a plant used for generations in folk medicine, can significantly reduce inflammation and arthritis symptoms in lab tests. Researchers observed less swelling, healthier joints, and signs of tissue protection. Just as important, the extract showed a promising safety profile at tested doses. The discovery could pave the way for new plant-based anti-inflammatory treatments.

Eating full-fat cheese and cream may be associated with a lower risk of dementia, according to a large study that tracked people for more than 25 years. Those who consumed higher amounts of these foods developed dementia less often than those who ate little or none. Interestingly, low-fat dairy products did not show the same pattern. Researchers caution that the findings show an association, not cause and effect.

A major international review has upended long-held ideas about how top performers are made. By analyzing nearly 35,000 elite achievers across science, music, chess, and sports, researchers found that early stars rarely become adult superstars. Most world-class performers developed slowly and explored multiple fields before specializing. The message is clear: talent grows through variety, not narrow focus.

Spanish researchers have created a powerful new open-source tool that helps uncover the hidden genetic networks driving cancer. Called RNACOREX, the software can analyze thousands of molecular interactions at once, revealing how genes communicate inside tumors and how those signals relate to patient survival. Tested across 13 different cancer types using international data, the tool matches the predictive power of advanced AI systems—while offering something rare in modern analytics: clear, interpretable explanations that help scientists understand why tumors behave the way they do.

A major new meta-analysis finds that vegetarian and vegan diets can support healthy growth in children when properly planned. Kids on plant-based diets often had better heart health markers, including lower “bad” cholesterol, and consumed more fiber and vitamins. But the study also flagged common nutrient gaps—especially vitamin B12 and calcium—without supplementation. Experts say plant-based eating is achievable for kids, but only with careful planning.

Long before opioids flooded communities, something else was quietly changing—and it may have helped set the stage for today’s crisis. A new study finds that as church attendance dropped among middle-aged, less educated white Americans, deaths from overdoses, suicide, and alcohol-related disease began to rise. The trend started years before OxyContin appeared, suggesting the opioid epidemic intensified a problem already underway.

Researchers have revealed that so-called “junk DNA” contains powerful switches that help control brain cells linked to Alzheimer’s disease. By experimentally testing nearly 1,000 DNA switches in human astrocytes, scientists identified around 150 that truly influence gene activity—many tied to known Alzheimer’s risk genes. The findings help explain why many disease-linked genetic changes sit outside genes themselves. The resulting dataset is now being used to train AI systems to predict gene control more accurately.

In a rare and historic achievement, Children’s Hospital Colorado successfully completed its first dual heart and liver transplant in a pediatric patient. The life-saving surgery was performed on 11-year-old Gracie Greenlaw, whose congenital heart condition eventually led to liver failure. Dozens of specialists worked together for years to prepare for a moment like this, executing a complex, 16-hour operation. Now months later, Gracie is home, in school, and thriving.

Spending a few hours a week helping others may slow the aging of the brain. Researchers found that both formal volunteering and informal acts, like helping neighbors or relatives, were linked to noticeably slower cognitive decline over time. The benefits added up year after year and didn’t require a huge time commitment. Even modest, everyday helping packed a powerful mental payoff.

A small tweak to mitochondrial energy production led to big gains in health and longevity. Mice engineered to boost a protein that helps mitochondria work more efficiently lived longer and showed better metabolism, stronger muscles, and healthier fat tissue. Their cells produced more energy while dialing down oxidative stress and inflammation tied to aging. The results hint that improving cellular power output could help slow the aging process itself.

A new bioluminescent tool allows neurons to glow on their own, letting scientists track brain activity without harmful lasers or fading signals. The advance makes it possible to watch individual brain cells fire for hours, offering a clearer, deeper look at how the brain works.

After injury, the visual system can recover by growing new neural connections rather than replacing lost cells. Researchers found that surviving eye cells formed extra branches that restored communication with the brain. These new pathways worked much like the originals. The repair process, however, was slower or incomplete in females, pointing to important biological differences in recovery.

Firefighter turnout gear is designed to shield first responders from extreme heat and danger, but new research suggests it may also introduce chemical exposures. A U.S. study found that brominated flame retardants are present across multiple layers of firefighter gear, including newer equipment marketed as PFAS-free. In some cases, these chemicals appeared at higher levels than the substances they were meant to replace.

Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before. This breakthrough may help explain why immunotherapy works for some cancers and how it could be improved for others.

More than 20% of young adults say they use cannabis or alcohol to fall asleep, with cannabis leading by a wide margin. Researchers warn this strategy can backfire, disrupting sleep quality and increasing the risk of long-term sleep and substance-use problems.

AI tools designed to diagnose cancer from tissue samples are quietly learning more than just disease patterns. New research shows these systems can infer patient demographics from pathology slides, leading to biased results for certain groups. The bias stems from how the models are trained and the data they see, not just from missing samples. Researchers also demonstrated a way to significantly reduce these disparities.

Researchers have identified a previously overlooked protein that helps regulate appetite and energy use in the body. This “helper” protein supports a key system that decides whether the body burns energy or stores it, and when it does not function properly, appetite signals can weaken.

A missing brain molecule may be disrupting neural wiring in Down syndrome, according to new research. Replacing it in adult mice rewired brain circuits and improved brain flexibility, challenging the idea that treatment must happen before birth.

Sorbitol, a popular sugar-free sweetener, may not be as harmless as its label suggests. Researchers found it can be turned into fructose in the liver, triggering effects similar to regular sugar. Gut bacteria can neutralize some of it—but too much sorbitol or glucose can overwhelm that defense. The result: yet another “healthy” sweetener that may stress the liver.

A rare tick-borne allergy linked to red meat has now been confirmed as deadly for the first time. A healthy New Jersey man collapsed and died hours after eating beef, with later testing revealing a severe allergic reaction tied to alpha-gal, a sugar spread by Lone Star tick bites. Symptoms often appear hours later, making the condition easy to miss. Researchers warn that growing tick populations could put more people at risk.

Kimchi may do far more than add flavor to meals—it could help fine-tune the human immune system. A clinical study using advanced single-cell genetic analysis found that regular kimchi consumption strengthens immune defenses while preventing harmful overreactions. Researchers observed improved activity in key immune cells, with effects varying depending on fermentation methods.