Medical and Health Sciences

Weight-loss drugs like Ozempic and Wegovy are changing how Americans spend money on food. A large Cornell study found households cut grocery spending by over 5% within six months, with even bigger drops at fast-food restaurants. Snack foods and sweets saw the steepest declines, while only a few categories like yogurt and fruit rose slightly. The effects linger for at least a year among continued users.

A large genetic screen has revealed how stem cells transform into brain cells, exposing hundreds of genes that make this process possible. Among the discoveries is PEDS1, a gene now linked to a previously unknown neurodevelopmental disorder in children. When PEDS1 does not work properly, brain growth and nerve cell formation are impaired. The findings help explain how early genetic changes can shape brain development and disease.

Roasted coffee may do more than wake you up—it could help control blood sugar. Researchers discovered several new coffee compounds that inhibit α-glucosidase, a key enzyme linked to type 2 diabetes. Some of these molecules were even more potent than a common anti-diabetic drug. The study also introduced a faster, greener way to uncover health-boosting compounds in complex foods.

KAIST researchers have developed a way to reprogram immune cells already inside tumors into cancer-killing machines. A drug injected directly into the tumor is absorbed by macrophages, prompting them to recognize and attack cancer cells while activating nearby immune defenses. This eliminates the need for lab-based cell extraction and modification. In animal models, the strategy significantly slowed tumor growth and sparked strong anticancer immune responses.

In a striking real-world experiment, flu patients spent days indoors with healthy volunteers, but the virus never spread. Researchers found that limited coughing and well-mixed indoor air kept virus levels low, even with close contact. Age may have helped too, since middle-aged adults are less likely to catch the flu than younger people. The results highlight ventilation, air movement, and masks as key defenses against infection.

A new international trial has delivered striking results for people on dialysis, showing that daily fish oil supplements can sharply reduce serious heart-related events. Patients taking fish oil had far fewer heart attacks, strokes, and cardiac deaths than those on placebo. Researchers say this is especially important because dialysis patients face extreme cardiovascular risk and few proven treatment options. The findings mark a rare breakthrough in kidney care.

Although the gut renews itself constantly, its stem cells accumulate age-related molecular changes that quietly alter how genes are switched on and off. Scientists found that this “epigenetic drift” follows a clear pattern and appears in both aging intestines and most colon cancers. Some regions age faster than others, forming a patchwork of weakened tissue more prone to degeneration. Encouragingly, researchers showed this drift can be slowed—and partly reversed—by restoring iron levels or key cellular signals.

Sleep isn’t just about feeling rested—it may be one of the strongest predictors of how long you live. Researchers analyzing nationwide data found that insufficient sleep was more closely tied to shorter life expectancy than diet, exercise, or loneliness. The connection was consistent year after year and across most U.S. states. The takeaway is simple but powerful: getting seven to nine hours of sleep may be one of the best things you can do for long-term health.

New research shows that aging blood can accelerate Alzheimer’s-like changes in the brain, while younger blood may offer protection. In mouse experiments, older blood worsened memory performance and increased toxic protein buildup linked to the disease. The study also uncovered widespread changes in brain proteins tied to communication and signaling. The findings point to the blood as a powerful influencer of brain health—and a promising new therapeutic target.

Pancreatic cancer is notoriously hard to treat, often resisting therapies that target its most common mutations. Researchers have now uncovered a hidden three-part loop that fuels tumor growth, involving the cancer drivers SRSF1, AURKA, and MYC. By targeting just one part of this loop with a specially designed molecule, they were able to shut down all three at once. The result was a dramatic loss of tumor cell survival, offering new hope for smarter, more effective treatments.

Sugar-loving mouth bacteria create acids that damage teeth, but arginine can help fight back. In a clinical trial, arginine-treated dental plaque stayed less acidic, became structurally less harmful, and supported more beneficial bacteria. These changes made the biofilms less aggressive after sugar exposure. The results point to arginine as a promising, natural addition to cavity-prevention strategies.

Scientists at USC are launching a new trial to test a tiny stem cell implant that could restore vision in people with advanced dry macular degeneration. The hair-thin patch replaces damaged retinal cells responsible for sharp, central vision. Earlier studies showed the implant was safe and helped some patients see better. Researchers now hope it can deliver meaningful, lasting improvements in eyesight.

A large genetic study shows that many people carry DNA sequences that slowly expand as they get older. Common genetic variants can dramatically alter how fast this expansion happens, sometimes multiplying the pace by four. Researchers also identified specific DNA expansions linked to severe kidney and liver disease. The findings suggest that age-related DNA instability is far more common than previously realized.

Foods that rely heavily on preservatives may be doing more than extending shelf life. In a large study spanning more than a decade, people with the highest intake of preservative additives were far more likely to develop type 2 diabetes. The increased risk appeared across many commonly used additives found in everyday processed foods. Researchers say the findings support advice to limit highly processed products when possible.

Researchers have developed a new class of antibodies that amplify the immune system’s ability to fight cancer. By clustering immune receptors that normally receive weak signals from tumors, these four-pronged antibodies push T cells into full attack mode. In early studies, they outperformed conventional antibodies at activating cancer-killing immune cells. The work opens the door to more effective immunotherapy treatments.

Stanford researchers have developed an AI that can predict future disease risk using data from just one night of sleep. The system analyzes detailed physiological signals, looking for hidden patterns across the brain, heart, and breathing. It successfully forecast risks for conditions like cancer, dementia, and heart disease. The results suggest sleep contains early health warnings doctors have largely overlooked.

A new study finds that TikTok videos about gout frequently spread confusing or inaccurate advice. Most clips focus on diet changes and supplements, while barely mentioning the long-term treatments doctors say are essential for controlling the disease. Many videos also frame gout as a lifestyle problem, rather than a condition driven largely by genetics and underlying health factors. Researchers say the platform has huge potential—but only if accurate medical voices step in.

DNA doesn’t just sit still inside our cells — it folds, loops, and rearranges in ways that shape how genes behave. Researchers have now mapped this hidden architecture in unprecedented detail, showing how genome structure changes from cell to cell and over time. These insights reveal why many disease-linked mutations outside genes can still cause harm. The findings could speed up the discovery of genetic risks and inspire new ways to target diseases.

Long COVID affects an estimated 65 million people worldwide and can damage the brain, heart, blood vessels, and immune system long after infection. Researchers now link symptoms to lingering virus, inflammation, micro-clots, and disrupted energy metabolism. While structured rehab and pacing can improve quality of life, a growing list of experimental treatments—from antivirals and metformin to microbiome therapies and biologics—shows early promise. Clear answers, however, are still limited by small studies and the lack of large, definitive trials.

Scientists are uncovering why Brazil may be one of the most important yet underused resources for studying extreme longevity. Its highly diverse population harbors millions of genetic variants missing from standard datasets, including rare changes linked to immune strength and cellular maintenance. Brazilian supercentenarians often remain mentally sharp, survive serious infections, and come from families where multiple members live past 100. Together, they reveal aging not as inevitable decline, but as a form of biological resilience.

A brief, intense workout may do more than boost fitness—it could help fight cancer. Researchers found that just 10 minutes of hard exercise releases molecules into the bloodstream that switch on DNA repair and shut down cancer growth signals. When these molecules were applied to bowel cancer cells, hundreds of cancer-related genes changed activity. The discovery helps explain how exercise lowers cancer risk and hints at future therapies inspired by movement.

A large review of studies suggests that exercise can ease depression about as effectively as psychological therapy. Compared with antidepressants, exercise showed similar benefits, though the evidence was less certain. Researchers found that light to moderate activity over multiple sessions worked best, with few side effects. While it’s not a cure-all, exercise may be a powerful and accessible tool for many people.

Exercise doesn’t just challenge the body; it challenges how the brain interprets effort. Scientists discovered that vibrating tendons before cycling allowed people to push harder without feeling like they were working more. Their muscles and hearts worked overtime, but their sense of strain stayed the same. This brain-body mismatch could one day help make exercise feel less intimidating, especially for people who struggle to stay active.

Bariatric surgery far outperformed GLP-1 weight loss drugs in a new real-world comparison of more than 50,000 patients. Two years after treatment, surgery patients lost about 58 pounds on average, while those using semaglutide or tirzepatide lost roughly 12 pounds. Even patients who stayed on GLP-1 drugs for a full year saw much smaller results than surgical patients. High dropout rates and real-world challenges appear to blunt the drugs’ effectiveness.

Researchers in Japan built a miniature human brain circuit using fused stem-cell–derived organoids, allowing them to watch the thalamus and cortex interact in real time. They found that the thalamus plays a decisive role in maturing the cortex and organizing its neural networks. Signals from the thalamus triggered synchronized activity in specific neuron types, while others remained unaffected. The system closely mimics human brain development and could transform how scientists study neurological disorders.

Researchers have reconstructed ancient herpesvirus genomes from Iron Age and medieval Europeans, revealing that HHV-6 has been infecting humans for at least 2,500 years. Some people inherited the virus directly in their DNA, passing it down across generations. The study shows that these viruses evolved alongside humans—and that one strain eventually lost its ability to integrate into our chromosomes. It’s the first time this long, intimate relationship has been proven with ancient genetic evidence.

Researchers have developed a magnetic nanomaterial that can kill bone cancer cells and support bone regeneration at the same time. The material heats up under a magnetic field to destroy tumors, while its bioactive coating helps it bond to bone and stimulate healing. Tests showed rapid formation of bone-like minerals, a key sign of successful integration. The breakthrough could lead to smarter, less invasive treatments for bone tumors.

Global cancer cases have surged dramatically, doubling since 1990 and reaching 18.5 million new diagnoses in 2023. Deaths have also climbed to over 10 million a year, with the steepest increases hitting low- and middle-income countries. Without urgent action, researchers project more than 30 million new cases annually by 2050. Alarmingly, around four in ten cancer deaths are tied to preventable risks such as smoking, poor diet, and high blood sugar.

Scientists have discovered that wildfires release far more air-polluting gases than previously estimated. Many of these hidden emissions can transform into fine particles that are dangerous to breathe. The study shows wildfire pollution rivals human-made emissions in some parts of the world. This helps explain why wildfire smoke can linger and worsen air quality long after the flames are gone.

Teens who sleep in on weekends may be giving their mental health a boost. A new study found that young people who made up for lost weekday sleep had a significantly lower risk of depression. While consistent sleep is still best, weekend catch-up sleep appears to offer meaningful protection. The findings highlight how powerful sleep can be for adolescent well-being.

A familiar mouth bacterium best known for causing cavities may also be quietly influencing the brain. Scientists found that when this microbe settles in the gut, it produces compounds that can travel through the bloodstream and harm neurons involved in movement. In animal studies, this process triggered inflammation, motor problems, and brain changes linked to Parkinson’s disease. The findings hint that protecting oral and gut health could help protect the brain as well.

Researchers at USF Health have discovered a new way opioid receptors can work that may lead to safer pain medications. Their findings show that certain experimental compounds can amplify pain relief without intensifying dangerous side effects like suppressed breathing. This research offers a fresh blueprint for designing opioids that last longer, work better, and pose fewer risks. It also opens doors to safer treatments for other brain disorders.

Many people with multiple sclerosis struggle with balance and coordination, and this study uncovers a hidden reason why. Researchers found that inflammation in the brain disrupts the energy supply of vital movement-controlling neurons. As their mitochondria fail, these cells weaken and eventually die, worsening motor problems over time. Protecting brain energy systems could open the door to slowing these symptoms.

Scientists have found that combining silybin with carvedilol works far better against liver fibrosis than either drug alone. The duo targets the root drivers of liver scarring, sharply reducing collagen buildup and liver damage in experimental models. Importantly, both drugs are already approved and commonly prescribed. That makes this discovery especially promising for rapid clinical translation.

Scientists have uncovered a surprising viral shortcut that turns moving cells into delivery vehicles for infection. Instead of spreading one virus at a time, infected cells bundle viral material into large structures called Migrions and pass them directly to new cells. This collective delivery jump-starts viral replication and boosts disease severity. The finding reveals a migration-based route of viral spread that defies classic models of infection.

A long-running debate over Tamiflu’s safety in children may finally be settled. Researchers found that influenza, not the antiviral medication, was linked to serious neuropsychiatric events like seizures and hallucinations. Even more striking, kids treated with Tamiflu had about half the risk of these events compared to untreated children with the flu. The results suggest the drug may be protective rather than harmful.

Nearly all women in STEM graduate programs report feeling like impostors, despite strong evidence of success. This mindset leads many to dismiss their achievements as luck and fear being “found out.” Research links impostorism to worse mental health, higher burnout, and increased thoughts of dropping out. Supportive environments and shifting beliefs about intelligence may help break the cycle.

The idea that we make over 200 unconscious food choices a day has been repeated for years, but new research shows the number is more illusion than insight. The famous figure comes from a counting method that unintentionally exaggerates how many decisions people really make. Researchers warn that framing eating as mostly “mindless” can undermine confidence and self-control. A more realistic view focuses on meaningful choices—and practical strategies that make healthy decisions easier.

New research shows gut bacteria can directly influence how the brain develops and functions. When scientists transferred microbes from different primates into mice, the animals’ brains began to resemble those of the original host species. Microbes from large-brained primates boosted brain energy and learning pathways, while others triggered very different patterns. The results suggest gut microbes may have played a hidden role in shaping the human brain—and could influence mental health.

A protein once thought to simply help cancer cells avoid death turns out to do much more. MCL1 actively drives cancer metabolism by controlling the powerful mTOR growth pathway, tying survival and energy use together. This insight explains why MCL1-targeting drugs can be effective—but also why they sometimes damage the heart. Researchers have now identified a way to reduce that risk, potentially unlocking safer cancer therapies.

A large study has revealed that dozens of widely used chemicals can damage beneficial gut bacteria. Many of these substances, found in pesticides and everyday industrial products, were never thought to affect living organisms at all. When gut bacteria are stressed by these chemicals, some may also become resistant to antibiotics. The research raises new questions about how chemical exposure could be influencing human health behind the scenes.

A new CRISPR breakthrough shows scientists can turn genes back on without cutting DNA, by removing chemical tags that act like molecular anchors. The work confirms these tags actively silence genes, settling a long-running scientific debate. This gentler form of gene editing could offer a safer way to treat Sickle Cell disease by reactivating a fetal blood gene. Researchers say it opens the door to powerful therapies with fewer unintended side effects.

Researchers have developed experimental compounds that make cells burn more calories by subtly tweaking how mitochondria produce energy. Older versions of these chemicals were once used for weight loss—but were banned for being deadly. The new approach fine-tunes the effect, allowing cells to burn extra fuel safely. If successful, this could pave the way for new obesity treatments with added health benefits.

Researchers compared a traditional Chinese medicine, Yueju Pill, with a standard antidepressant and found both reduced depression symptoms. However, only Yueju Pill increased a brain-supporting protein associated with mood improvement. Brain imaging showed that unique network patterns—especially in visual regions—could predict who benefited most from Yueju Pill. This opens the door to more personalized depression treatments guided by brain scans.

New research shows that AI doesn’t need endless training data to start acting more like a human brain. When researchers redesigned AI systems to better resemble biological brains, some models produced brain-like activity without any training at all. This challenges today’s data-hungry approach to AI development. The work suggests smarter design could dramatically speed up learning while slashing costs and energy use.

Feeling warm or cold doesn’t just register on the skin—it changes how connected we feel to our own bodies. Research shows that temperature sensations help shape body ownership, emotional regulation, and mental well-being. Disruptions in thermal perception are linked to conditions like depression, trauma, and stroke-related body disconnect. These insights could lead to new sensory-based mental health treatments and more lifelike prosthetics.

Not all microbes are villains—many are vital to keeping us healthy. Researchers have created a world-first database that tracks beneficial bacteria and natural compounds linked to immune strength, stress reduction, and resilience. The findings challenge the long-standing obsession with germs as threats and instead highlight the hidden health benefits of biodiversity. This shift could influence everything from urban design to environmental restoration.

A groundbreaking study shows that breast cancer screening works better when it’s personalized. Instead of annual mammograms for all, women were screened based on genetics, health history, and lifestyle factors. This approach reduced advanced cancers without increasing risk for those screened less often. Most women preferred the personalized model, hinting at a major shift in future screening guidelines.

UK experts are warning that access to new weight-loss drugs could depend more on wealth than medical need. Strict NHS criteria mean only a limited number of patients will receive Mounjaro, while many others must pay privately. Researchers say this risks worsening existing health inequalities, especially for groups whose conditions are often missed or under-diagnosed. They are calling for fairer, more inclusive access before gaps in care widen further.

Type 2 diabetes doesn’t just raise the risk of heart disease—it physically reshapes the heart itself. Researchers studying donated human hearts found that diabetes disrupts how heart cells produce energy, weakens the muscle’s structure, and triggers a buildup of stiff, fibrous tissue that makes it harder for the heart to pump. These changes are especially severe in people with ischemic heart disease, the most common cause of heart failure.

Researchers have discovered a way to help aging intestines heal themselves using CAR T-cell therapy. By targeting senescent cells that build up over time, the treatment boosted gut regeneration, reduced inflammation, and improved nutrient absorption in mice. It even helped protect the intestine from radiation damage, with benefits lasting up to a year. Early results in human intestinal cells suggest the approach could one day improve gut health in older adults and cancer patients.

Your daily rhythm may matter more for brain health than previously thought. Older adults with weaker, more disrupted activity patterns were far more likely to develop dementia than those with steady routines. A later daily energy peak was also linked to higher risk. The study points to the body clock as a possible early warning sign for cognitive decline.

The brain constantly blends split-second reactions with slower, more thoughtful processing, and new research shows how it pulls this off. Scientists discovered that brain regions operate on different internal clocks and rely on white matter connections to share information across these timescales. The way this timing is organized affects how efficiently the brain switches between activity patterns tied to behavior. Differences in this system may help explain why people vary in cognitive ability.

Time-restricted eating has been widely promoted as a simple way to boost metabolic health, but new research paints a more complicated picture. When calorie intake stayed the same, an eight-hour eating window did not improve insulin sensitivity or cardiovascular markers. What did change was the body’s internal clock, which shifted based on meal timing and altered sleep patterns. The results suggest calorie reduction, not the eating window itself, may be the real driver of health benefits.

Researchers discovered that clogged brain “drains” show up early in people at risk of Alzheimer’s disease. These blockages, easily seen on standard MRI scans, are tied to toxic protein buildup linked to memory loss and cognitive decline. In some cases, they may signal Alzheimer’s earlier than other commonly used brain markers. This could help physicians detect the disease earlier, before irreversible damage sets in.

Being active boosts your daily calorie burn more than previously thought. Researchers found that increased physical activity raises total energy use without triggering the body to conserve energy elsewhere. Basic functions keep running at full speed, even as movement increases. The result: exercise truly adds to your energy output rather than being metabolically “offset.”

New research suggests that even light alcohol use may carry serious risks. A large study in India found that drinking just one standard drink a day is linked to a roughly 50% higher risk of mouth cancer, with the greatest danger tied to locally brewed alcohol. When alcohol use overlaps with chewing tobacco, the effect becomes especially severe, potentially explaining nearly two-thirds of all cases nationwide.

Tiny lab-grown brains are offering an unprecedented look at how schizophrenia and bipolar disorder disrupt neural activity. Researchers found distinct electrical firing patterns that could identify these conditions with high accuracy. The discovery opens the door to more precise diagnoses and personalized drug testing. Instead of guessing medications, doctors may one day see what works before treating the patient.

Weight loss restored healthy metabolism in both young and mid-aged mice, but the brain told a different story. In mid-aged animals, slimming down actually worsened inflammation in a brain region tied to appetite and energy balance. While this inflammation eventually subsided, brain inflammation has been linked to cognitive decline and neurodegenerative disease. The results suggest that weight loss in midlife may not be as straightforward as once thought.

A randomized trial from Vanderbilt-Ingram Cancer Center reveals that magnesium may be the missing key to keeping vitamin D levels in balance. The study found that magnesium raised vitamin D in people who were deficient while dialing it down in those with overly high levels—suggesting a powerful regulating effect. This could help explain why vitamin D supplements don’t work the same way for everyone and why past studies linking vitamin D to cancer and heart disease have produced mixed results.