Medical and Health Sciences

A new study found that chronic wasting disease can sometimes spread silently, with infectious prions present even in animals that show no symptoms. While there is no confirmed human risk, researchers say the disease’s ability to evolve and spread across species warrants close attention.

Many people prescribed GLP-1 drugs for type 2 diabetes (such as Victoza, Ozempic, or tirzepatide) stop taking them, but a surprising number later return to treatment. Researchers found that newer medications appear to keep patients on therapy longer, while side effects remain a major reason for discontinuation.

A large real-world study suggests semaglutide (Ozempic, Wegovy, Rybelsus) may offer an unexpected bonus for people with type 2 diabetes: stronger protection against bone fractures while delivering greater weight loss. Researchers analyzing health records from nearly 60,000 adults found that people taking semaglutide experienced about 15% fewer fractures than those using other common weight-loss medications, despite losing more weight.

Humans evolved to pay close attention to danger, but today that instinct is being overwhelmed by an endless supply of bad news from around the world. Researchers say the answer isn’t to stop following current events—it’s to build healthier habits around how, when, and where we get our news.

A copper-based compound restored the brain’s ability to clear toxic Alzheimer’s proteins, dramatically reducing amyloid buildup and improving memory in laboratory experiments. The findings point to a potentially fast-tracked new treatment strategy because the drug has already been tested in humans for other neurological conditions.

For years, calcium and vitamin D supplements have been promoted as a simple way for older adults to protect their bones and prevent falls. But a massive review of nearly 154,000 people found that calcium, vitamin D, or a combination of both provided little to no meaningful protection against fractures or falls for most older adults.

A large-scale study suggests that men with higher levels of the amino acid tyrosine may have shorter lifespans, potentially losing close to a year of life expectancy. The finding is especially intriguing because tyrosine is commonly associated with brain health and is often used in supplements aimed at boosting focus and performance.

A new oral GLP-1 medication helped people with type 2 diabetes dramatically improve blood sugar control and lose weight in a major clinical trial. The results suggest that highly effective diabetes treatments may soon become available in a much more convenient pill form.

Researchers used genome editing to block the production of red pigments in lettuce, causing other beneficial plant compounds to build up instead. The lettuce continued to grow normally, pointing toward a new way to create crops with customized nutritional profiles.

A new whey protein manufacturing technique could make protein shakes taste better and feel smoother in the mouth. Researchers traced unwanted bitterness to concentrated minerals and found a way to remove them without sacrificing the improved texture.

Bringing blood sugar levels back to normal may dramatically reduce the danger posed by prediabetes. Researchers found that people who reversed prediabetes cut their risk of cardiovascular death or hospitalization for heart failure by 58% and lowered their chances of major heart problems such as heart attacks and strokes by 42%. The benefits lasted for decades and were seen across large long-term studies in both the U.S. and China.

A surprising new study suggests that completely eliminating sugar may backfire. Mice on a sucrose-free low-fat diet showed worse blood sugar control, increased inflammation, disrupted gut bacteria, and signs of fatty liver compared with mice that consumed some sucrose. Researchers say the results highlight the importance of a balanced diet and a healthy gut microbiome rather than focusing solely on cutting out sugar.

People taking popular weight-loss drugs such as Ozempic, Wegovy, Mounjaro, and Zepbound may be losing pounds, but they could also be moving less. Researchers analyzing Fitbit data found that daily step counts and exercise levels dropped after people started these medications, despite successful weight loss. Because the drugs can reduce muscle mass along with fat, the decline in physical activity raises concerns about preserving strength and long-term health.

A new international study finds that middle-aged Americans are lonelier, more depressed, and experiencing worse memory and health than earlier generations. Researchers say growing financial strain, weaker social supports, and chronic stress may explain why the U.S. is falling behind other wealthy nations.

A three-year study of nearly 4,000 adults ranging from age 19 to 94 found that brain health can improve at any age, challenging the common belief that mental sharpness must decline as we get older. Participants spent just a few minutes a day on brain-training activities, and researchers found measurable gains across multiple aspects of brain health, including thinking clarity, emotional well-being, and sense of purpose.

Learning a musical instrument later in life may help keep the brain younger for longer. In a four-year study, older adults who continued practicing maintained their memory performance and showed less age-related brain shrinkage than those who quit. The benefits were especially noticeable in brain regions tied to memory and learning.

A child psychologist says grandparents are more important than ever as youth mental health challenges continue to rise. He argues that children need supportive relationships, meaningful conversations, and a sense of purpose—not just pressure to achieve. Grandparents can help by listening, encouraging, and creating positive experiences that strengthen emotional resilience.

Scientists have uncovered a surprising new genetic cause of a rare movement disorder after analyzing nearly 3,000 patients with conditions affecting coordination and muscle control. The team identified mutations in a gene called CD99L2, previously linked only to the immune system, and showed that it plays an essential role in keeping nerve-cell communication running smoothly.

A new experimental vaccine developed by Scripps Research could offer a powerful new way to prevent fentanyl overdoses by stopping the drug before it reaches the brain. Rather than targeting only fentanyl itself, the vaccine trains the immune system to recognize a broad range of fentanyl-related designer drugs, including some of the most dangerous variants.

A new nature-inspired membrane uses perfectly uniform one-nanometer pores to filter molecules with remarkable precision. The technology could transform industries such as pharmaceuticals and textiles by reducing energy consumption, improving water reuse, and delivering separation performance far beyond current filters.

A low-calorie fasting-style diet significantly reduced inflammation linked to gum disease in a small clinical study. The findings suggest that what people eat may influence gum health almost as much as what they do with a toothbrush.

Researchers discovered that mutations linked to blood cancers may help trigger Alzheimer’s disease by creating overly inflammatory immune cells in the brain. The unexpected finding could lead to new blood-based screening methods and potential treatments borrowed from cancer medicine.

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them.

Just 90–120 minutes of strength training a week may deliver some of the biggest long-term health rewards, according to a study tracking more than 147,000 people for 30 years. That amount was linked to lower risks of death overall, particularly from cardiovascular and neurological diseases. Combining strength workouts with aerobic exercise produced even stronger benefits.

A potentially dangerous tapeworm linked to severe, cancer-like disease has now been found in the Pacific Northwest, marking its first detection in wild animals along the U.S. West Coast. Researchers discovered the parasite, Echinococcus multilocularis, in 37% of coyotes tested around Puget Sound—a surprisingly high rate for a region where it had never been reported until recently.

Researchers discovered that declining levels of phosphatidylcholine may be a major cause of age-related mitochondrial dysfunction and loss of cellular energy. Remarkably, boosting this nutrient restored more youthful mitochondrial performance in aging organisms, suggesting some aspects of aging can be slowed or reversed.

Cancer cells often survive treatment by fixing the DNA damage that therapy is meant to cause. Researchers found that UNI418 can disrupt this repair ability, leaving cancer cells more exposed. When combined with a PARP inhibitor, it helped resistant cancer cells respond to treatment again. The findings point to a new strategy for overcoming cancer drug resistance.

Researchers gave top AI models a classic attention test used in psychology and found a major flaw. While the models could correctly name colors in short lists, their performance deteriorated sharply as the task became longer and more complex. Some leading systems fell from over 90% accuracy to nearly complete failure.

A groundbreaking new connectome maps every neural connection in an adult fruit fly’s central nervous system, creating an unprecedented view of how the brain and body work together. The findings suggest that complex behaviors emerge from distributed local circuits rather than a single central controller, offering new clues about intelligence, movement, and brain function.

A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why.

A common sign of hearing loss isn’t complete silence — it’s struggling to follow conversations, especially in noisy places. Experts say hearing loss and tinnitus, the ringing or buzzing many people experience, often start when delicate cells inside the ear become damaged from aging or long-term noise exposure. Beyond making it harder to hear, these conditions can affect sleep, concentration, mood, and even increase the risk of falls and cognitive decline.

“Chemo brain” affects up to 80% of people receiving chemotherapy, making everyday tasks harder. In a new trial, cancer patients who followed a home-based exercise program showed better attention and fewer noticeable cognitive problems than those who received a placebo. Low-dose ibuprofen also improved some cognitive measures, though its effects were less consistent.

A study of more than 2,100 adults found that eating more ultra-processed foods was linked to poorer attention and slower mental processing, even among people with otherwise healthy diets. Researchers also found higher consumption was associated with increased dementia risk factors, raising concerns about the hidden cognitive costs of heavily processed foods.

A surprising gut-heart connection may help explain why sleep apnea increases the risk of cardiovascular disease. In mice, disabling a bile acid receptor called FXR sharply reduced plaque buildup, opening the door to potential new treatments based on gut microbes and their chemical signals.

Tea may help protect against heart disease, diabetes, cancer, cognitive decline, and age related muscle loss, according to a major review. But the way you drink it matters, since bottled and bubble teas often contain ingredients that can diminish tea's health benefits.

Scientists have uncovered a hidden immune system "brake" that may help cancers avoid being destroyed. The molecule, called SLAMF6, weakens the body's cancer-fighting T cells and can leave them exhausted over time. Researchers developed antibodies that block this brake, allowing immune cells to stay stronger and attack tumors more effectively in mice.

The largest review ever conducted on opioids for acute pain found that these widely prescribed drugs often deliver only small, short-lived benefits. For many common conditions, including some surgeries and kidney stone pain, opioids performed no better than a placebo. Researchers also found higher rates of side effects and warned that dependence can begin after only a short period of use.

Researchers have identified a new Alzheimer’s target and created an experimental compound that blocks a damaging process inside brain cells. In mice, the treatment slowed nerve cell loss, reduced Alzheimer’s-related changes, and even appeared to promote healthier aging.

Scientists have uncovered a key brain signal that helps us break old habits and adapt when circumstances suddenly change. By watching mice navigate a virtual maze, researchers found that disappointment—when an expected reward failed to appear—triggered a surge of the neurotransmitter acetylcholine, making the animals more likely to try a new strategy. When acetylcholine was blocked, the mice became less flexible and were more likely to stick with outdated choices.

A major long-term study of more than 54,000 adults found that where nitrate comes from may matter far more than how much you consume. People who got more nitrate from vegetables—roughly the amount in a cup of baby spinach a day—had a lower risk of developing dementia, while higher nitrate and nitrite intake from red meat, processed meat, and even drinking water was linked to a greater risk.

A trio of major studies found that finerenone may protect the kidneys and heart in far more people than previously thought. The drug significantly slowed kidney disease progression and reduced the risks of kidney failure, heart failure, cardiovascular death, and overall mortality. Researchers saw benefits not only in patients with diabetes but also in those with non-diabetic kidney disease, a group with limited treatment options.

A traditional Chinese medicinal root used for over a thousand years is attracting new scientific attention for its potential to combat hair loss. Studies suggest Polygonum multiflorum can block harmful hormones, activate hair-growth signals, protect follicles, and boost blood flow to the scalp. Researchers say the herb’s effects align remarkably well with both ancient descriptions and modern hair biology.

A large study found that women taking GLP-1 drugs, the medication class behind Ozempic, Wegovy, Mounjaro, and Zepbound, were about 30% less likely to develop breast cancer. Researchers say the findings are promising but not yet proof, and clinical trials are now being planned to test whether these drugs could help prevent breast cancer.

Supplements are often marketed as shortcuts to better health, but for many older adults, the real issue is whether they have a specific deficiency. Vitamins like B12 and D can play an important role when levels are low, while protein may be one of the most overlooked nutrients for maintaining strength and independence. More isn’t always better, though—some supplements can cause harm or interact with medications.

Scientists warn that free-living amoebae may be an underappreciated public health threat, capable of causing deadly infections and shielding other dangerous microbes from water treatment. Climate change and aging infrastructure could help these resilient organisms spread more widely in the years ahead.

Scientists have successfully tested an AI-designed universal coronavirus vaccine in humans for the first time, finding it to be safe and well tolerated. The vaccine generated immune responses against multiple coronaviruses, including SARS-CoV-2, SARS, and related bat viruses with pandemic potential. By targeting features shared across an entire virus family, it aims to provide protection even as viruses evolve.

Scientists have identified genetic variants that may make some people less responsive to GLP-1 drugs used to treat Type 2 diabetes. Roughly 10% of the population carries these variants, which appear to cause a mysterious form of "GLP-1 resistance." In several clinical trials, carriers were significantly less likely to reach healthy blood sugar targets while taking GLP-1 medications.

A major review of nearly 8,000 participants found that collagen supplements can improve skin health and ease osteoarthritis symptoms, especially when taken consistently over longer periods. Researchers also found modest benefits for muscle and tendon health. But the results challenge claims that collagen enhances sports performance, as it showed little effect on recovery or post-workout soreness.

A large study of older adults in Brazil found that adding extra salt at the table is still a common habit, especially among men. While too much salt is linked to serious health problems and faster cognitive decline, researchers discovered that women’s salt-shaking habits were tied more closely to lifestyle and diet.

For decades, pancreatic cancer has been one of the most lethal cancers, with few effective treatment options. A new drug, daraxonrasib, targets the KRAS mutation that fuels most pancreatic tumors—something many scientists once thought couldn't be done. In a major clinical trial, the treatment nearly doubled survival for patients with advanced disease and reduced the risk of death by 60%.

A newly discovered genetic clock acts as the master timekeeper for development, orchestrating crucial bursts of gene activity throughout a worm’s growth. When the clock is disrupted, development stops, offering fresh clues about how growth-related disorders may arise.

Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a key immune-recognition molecule called MHC I—a common trick used to hide from “killer” T cells—they can actually become more vulnerable to attack by a different group of immune cells known as CD4+ “helper” T cells.

A massive study of more than 600,000 U.S. veterans suggests that popular GLP-1 drugs such as semaglutide may do far more than help with diabetes and weight loss—they could also fight addiction itself. Researchers found that people taking these medications were less likely to develop substance use disorders involving alcohol, nicotine, cannabis, cocaine, opioids, and other drugs, while those already struggling with addiction experienced fewer overdoses, hospitalizations, emergency visits, and drug-related deaths.

Scientists have developed an experimental diabetes and obesity pill that works in a completely different way from drugs like Ozempic. Rather than reducing hunger, it activates metabolism in skeletal muscle, helping lower blood sugar and increase fat burning while preserving muscle mass. Early clinical results suggest the treatment is safe and well tolerated.

A newly identified group of amygdala neurons appears to play a central role in anxiety and social behavior. Restoring normal activity in this tiny brain circuit reversed anxiety and social deficits in mice, revealing a promising new target for future treatments.

French fries may be the real potato problem. A large study tracking more than 205,000 people for nearly 40 years found that eating three servings of fries per week was linked to a 20% higher risk of developing type 2 diabetes, while baked, boiled, or mashed potatoes showed no significant increase in risk. The research also found that swapping potatoes for whole grains lowered diabetes risk, while replacing them with white rice had the opposite effect.

Scientists have uncovered evidence that autism may include at least two biologically distinct subtypes, each marked by a different pattern of brain communication. By combining brain scans from nearly 1,000 people with autism with insights from 20 genetically engineered mouse models, researchers identified a “hyperconnectivity” subtype, where brain regions communicate more than usual, and a “hypoconnectivity” subtype, where communication is reduced.

A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time. When NFIL3 was disabled, the cells remained stronger for longer and controlled tumors more effectively in animal models.

A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year of life, and certain combinations were linked to early signs of autism and ADHD by age three.

Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.