Medical and Health Sciences

A next-generation drug tested in yeast was found to extend lifespan and slow aging by influencing a major growth-control pathway. Researchers also uncovered an unexpected role for agmatinases, enzymes that help keep this pathway in balance. Diet and gut microbes may affect aging more than expected because they produce the metabolites involved.

Regular consumption of polyphenol-rich foods like tea, coffee, berries, nuts, and whole grains may significantly support long-term heart health. A decade-long study of more than 3,100 adults found that those who consistently ate polyphenol-packed diets had healthier blood pressure and cholesterol levels, as well as lower predicted cardiovascular risk.

A large study found that people with impaired kidneys tend to have higher Alzheimer’s biomarkers, yet they don’t face a higher overall risk of dementia. For those who already have elevated biomarkers, kidney problems may speed up when symptoms appear. The findings show that kidney health can change how Alzheimer’s blood tests are read. Doctors may need to consider both organs to get a clearer picture.

Cedars-Sinai scientists have created a new experimental drug called TY1 that helps the body repair damaged DNA and restore injured tissue. The discovery came from studying tiny molecular messages released by heart cells that naturally support healing after injury. By identifying and recreating the most powerful of these messages, the team developed a synthetic RNA molecule that boosts the body’s DNA-repair system, reduces scarring, and may improve recovery after heart attacks and other diseases.

Researchers found that people with anxiety disorders consistently show lower choline levels in key brain regions that regulate thinking and emotions. This biochemical difference may help explain why the brain reacts more intensely to stress in anxiety conditions. Scientists believe nutrition could play a role in restoring balance, though more research is needed. Many Americans already fall short of recommended choline intake, making diet a potential area of interest.

Researchers studying people with major psychiatric disorders found that drinking up to four cups of coffee a day is associated with longer telomeres. This suggests a potential slowing of biological aging by about five years. However, drinking five or more cups showed no benefit and may even contribute to cellular damage. Coffee’s antioxidant and anti-inflammatory properties may help explain the effect.

A low-dose mix of zinc, serine, and branched-chain amino acids boosted neural function and social behavior in autism mouse models. The combination restored more typical synaptic protein patterns and reduced excessive amygdala activity. Individual supplements had no effect, showing that the nutrients must work together. The findings point toward a promising multi-nutrient strategy for influencing brain circuits involved in autism.

Scientists have captured a never-before-seen, high-resolution look at influenza’s stealthy invasion of human cells, revealing that the cells aren’t just helpless victims. Using a groundbreaking imaging technique, researchers discovered that our cells actually reach out and “grab” the virus as it searches for the perfect entry point, surfing along the membrane.

Stanford researchers found that gas stoves expose Americans to surprisingly high levels of nitrogen dioxide—often matching or exceeding outdoor pollution. For millions, cooking alone pushes NO2 over long-term safety thresholds. Smaller homes, renters, and rural households face the highest concentrations. Cleaner cooking technologies could substantially reduce the risks.

A unique vaccine rollout in Wales gave researchers an accidental natural experiment that revealed a striking reduction in dementia among seniors who received the shingles vaccine. The protective effect held steady across multiple analyses and was even stronger in women. Evidence also suggests benefits for people who already have dementia, hinting at a therapeutic effect.

A surprising link between constipation and kidney decline led researchers to test lubiprostone, revealing that it can protect kidney function. The results point toward gut-based, mitochondria-boosting therapies as a promising new avenue for CKD care.

Sweat carries a rich mix of biomarkers that advanced wearables can now track in real time. New AI-powered patches analyze biochemical patterns to detect disease risks, medication levels, or stress responses. Researchers are building ultra-sensitive microfluidic devices to read glucose, cortisol, and more—without needles or blood draws. The tech is still emerging, but its potential is huge.

College life creates a perfect storm for overeating, as students consume more calories when surrounded by friends, eating in dining halls, or following unstructured schedules. A four-week study using a mobile app revealed that students often underestimate how much they eat, especially in social or formal dining settings. Emotional influences, gender differences, and environmental cues all contribute to this subtle but consistent rise in intake.

Scientists discovered that the first 100 base pairs of human genes are unusually prone to mutations, especially during the earliest stages of embryonic development. These mosaic mutations often go undetected yet can still be passed on and cause disease. Large-scale genome analyses show that genes tied to cancer and brain function are particularly affected, with natural selection filtering out harmful variants. The study highlights the need to adjust genetic models and rethink how researchers identify disease-relevant mutations.

Researchers discovered that 168 common chemicals can disrupt the growth of beneficial gut bacteria, with some also promoting antibiotic resistance. Many of these substances—found in food, water, and household items—weren’t previously suspected of affecting living organisms. A new machine learning model now predicts which chemicals may harm the microbiome. The findings suggest safety testing must expand to consider gut health.

Researchers have solved the decades-old mystery behind how a common pregnancy drug lowers blood pressure. It turns out the medication blocks a fast-acting “oxygen alarm” inside cells. That same alarm helps brain tumors survive, meaning the drug unexpectedly weakens them, too. The discovery could inspire better treatments for both preeclampsia and brain cancer.

Scientists found that combining oxytocin with an Alk5 inhibitor revitalized extremely old male mice, boosting their lifespan and strength. Female mice showed only short-term improvements, highlighting a major sex difference in aging biology. The therapy restored youthful protein patterns in blood and targeted key pathways that drive tissue decline. Because the components are already clinically accessible, this approach could move toward human testing.

Scientists have discovered that a single gene, GRIN2A, can directly cause mental illness—something previously thought to stem only from many genes acting together. People with certain variants of this gene often develop psychiatric symptoms much earlier than expected, sometimes in childhood instead of adulthood. Even more surprising, some individuals show only mental health symptoms, without the seizures or learning problems usually linked to GRIN2A.

Nitrous oxide may offer quick, short-term relief for people with major depression, especially those who haven’t responded to standard medications. The meta-analysis found rapid improvements after a single dose and more sustained benefits after repeated treatments. Side effects were generally mild and brief, though researchers stress the need for larger, longer-term studies.

Dolichospermum, a type of cyanobacteria thriving in Lake Erie’s warming waters, has been identified as the surprising culprit behind the lake’s dangerous saxitoxins—some of the most potent natural neurotoxins known. Using advanced genome sequencing, researchers uncovered that only certain strains produce the toxin, and that warmer temperatures and low ammonium levels may tip the ecological balance in their favor.

Younger women are being diagnosed with breast cancer more often than screening guidelines anticipate. Many of these cancers are invasive and harder to treat, especially in those under 40. After analyzing 11 years of data, researchers found that this age group makes up a steady and significant share of diagnoses. The results support a stronger push for earlier risk evaluation.

Researchers have found a small but powerful switch inside breast cancer cells that helps them survive stressful conditions. When this switch flips, the cells activate protective programs that make them tougher and faster-growing. The finding reveals how tumors use stress to their benefit. It may open up new possibilities for therapies.

Scientists have found that common foods can contain hidden contaminants formed during cooking or through environmental exposure. A new testing method called QuEChERS helps identify these chemicals more quickly and with greater ease. The research showed strong accuracy and high sensitivity across multiple food samples. This streamlined approach could improve food safety checks while reducing chemical waste.

A high-speed “zap-and-freeze” method is giving scientists their clearest view yet of how brain cells send messages. By freezing tissue at the instant a signal fires, researchers revealed how synaptic vesicles behave in both mouse and human neurons. These insights could help explain why most Parkinson’s cases emerge without inherited genetic changes. The technique may also point to promising new research paths for therapy development.

A large study of brain scans shows that our neural wiring evolves through five major stages from birth to late old age. These phases are separated by sudden turning points that mark big shifts in how the brain is organized. The most surprising discovery is that adolescent-style development lasts into our early thirties. The work helps explain changing abilities and risks at different points in life.

Researchers found that fructose can prime immune cells to overreact to bacterial toxins. In healthy adults, fructose-sweetened drinks increased receptors that trigger inflammation. This heightened sensitivity may contribute to greater infection risk. The effects could be even more dangerous in people with metabolic diseases.

Researchers at UC Riverside have uncovered why soybean oil, one of America's most widely consumed ingredients, drives significant weight gain—at least in mice. The findings point not to the oil itself but to the fat-derived molecules it produces inside the body, called oxylipins, which can trigger inflammation, alter liver function, and influence genes tied to metabolism.

Scientists have uncovered how too much sunlight can flip a hidden switch inside skin cells that makes inflammation spiral out of control and increases the risk of cancer. Their research reveals that UV radiation breaks down a protective protein called YTHDF2, which normally prevents a small RNA signal from activating an immune sensor linked to dangerous inflammation. Once that protection is lost, a surprising chain reaction unfolds inside the cell, turning ordinary sun damage into a potential cancer trigger.

MIT scientists found that what we see is strongly influenced by how alert or active we are. Parts of the brain responsible for planning and control send specialized signals that either boost or quiet visual details. These areas seem to balance each other, sharpening important information while dimming distractions. The study shows vision is constantly being shaped by our internal state.

Scientists have uncovered a stepwise system that guides how the brain sorts and stabilizes lasting memories. By tracking brain activity during virtual reality learning tasks, researchers identified molecules that influence how long memories persist. Each molecule operates on a different timescale, forming a coordinated pattern of memory maintenance. The discoveries reshape how scientists understand memory formation.

Scientists found that RSV infection early in life can set the stage for childhood asthma, particularly in kids already genetically prone to allergies. The virus appears to skew the developing immune system toward exaggerated responses to everyday allergens. But when newborns were protected from RSV, asthma development was prevented. The results point to a powerful added benefit of RSV prevention tools now being rolled out globally.

Researchers have found that ongoing thyroid hormone imbalance in pregnancy may be linked to higher autism risk in children. Treated thyroid disorders did not show the same effect. The longer the imbalance lasted across trimesters, the more the risk appeared to rise. The study underscores the need for consistent thyroid monitoring.

Researchers studying thousands of canine genomes discovered that wolf DNA is still present in most dog breeds. This ancient genetic influence shows up in traits like body size, behavior, and environmental resilience. Even dogs bred far from wolves, including tiny chihuahuas, carry detectable wolf ancestry. The findings highlight how deeply intertwined the histories of dogs and wolves really are.

Millions face Medicare decisions each year, but many don’t take advantage of tools that can save them money and stress. Insurance marketing often overshadows unbiased options like SHIP, leaving people unaware of better choices. Comparing real costs—not just premiums—can prevent unpleasant surprises, especially when provider networks or drug rules change. New assistance programs for low-income adults offer valuable help for 2026.

Scientists have identified new anti-aging compounds produced by a little-studied blood bacterium. These indole metabolites were able to reduce inflammation, oxidative stress, and collagen-damaging activity in skin cell cultures. Three of the compounds, including two never seen before, showed particularly strong effects. The findings hint at a surprising new source for future skin-rejuvenation therapies.

Researchers analyzed data from over six million people to see how close residents lived to cannabis retailers. Neighborhoods near these shops experienced higher cannabis-related emergency visits compared with those farther away. The effect was strongest where multiple stores were packed into small areas. These trends suggest that store density plays a meaningful role in community health.

Researchers found that repeated head impacts can disrupt a key system that helps the brain wash away waste. In professional fighters, this system initially seems to work harder after trauma, then declines over time. MRI scans revealed that these changes may show up years before symptoms do. The work could help identify at-risk athletes earlier in their careers.

A large-scale Brazilian study found dangerous levels of toxic metals in popular children’s toys, with barium and lead topping the list. Researchers used sophisticated lab methods to identify 21 hazardous elements and test how easily they could be released when toys are mouthed. Even though only small fractions leach out, the total concentrations were so high that safety concerns remain critical.

A major review across 73 countries finds that access to antiseizure medications is rising, but safe prescribing isn’t keeping pace. Valproate—linked to serious birth defects—remains widely used in many regions despite WHO warnings. Limited access to newer drugs means millions may still be at risk. Researchers urge global education and stronger safeguards.

Princeton researchers found that the brain excels at learning because it reuses modular “cognitive blocks” across many tasks. Monkeys switching between visual categorization challenges revealed that the prefrontal cortex assembles these blocks like Legos to create new behaviors. This flexibility explains why humans learn quickly while AI models often forget old skills. The insights may help build better AI and new clinical treatments for impaired cognitive adaptability.

Data from over 47,000 dogs reveal that CBD is most often used in older pets with chronic health issues. Long-term CBD use was linked to reduced aggression, though other anxious behaviors didn’t improve. The trend was strongest among dogs whose owners lived in cannabis-friendly states.

Researchers discovered why bird flu can survive temperatures that stop human flu in its tracks. A key gene, PB1, gives avian viruses the ability to replicate even at fever-level heat. Mice experiments confirmed that fever cripples human-origin flu but not avian strains, especially those with avian-like PB1. These findings highlight how gene swapping could fuel future pandemics.

Long-term inhalation of toxic air appears to dull the protective power of regular workouts, according to a massive global study spanning more than a decade and over a million adults. While exercise still helps people live longer, its benefits shrink dramatically in regions with heavy fine particle pollution—especially above key PM2.5 thresholds common in many parts of the world. The researchers emphasize that outdoor activity shouldn’t stop, but better air quality could unlock far greater health gains.

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate stress-response pathways. Simulations show the damage makes mtDNA more rigid, possibly marking it for removal. The finding offers fresh clues to inflammation, aging, and diseases such as diabetes and neurodegeneration.

Warming up significantly improves muscle performance, particularly speed and power, by increasing muscle temperature. Both passive heat methods and light exercise warm-ups work, but mimicking the actual workout movements can offer extra benefits. When your body starts to feel coordinated and lightly sweaty, you’re ready to push into the main session.

Chronic cannabis use is increasingly linked to recurring bouts of vomiting, now officially classified as cannabis hyperemesis syndrome. The new ICD code helps doctors identify cases more consistently and gives researchers a clearer picture of how often it occurs. Patients often resist the diagnosis, and the condition’s causes remain murky. Relief can come from unusual sources like hot showers or capsaicin cream.

University of Queensland researchers visualized yellow fever virus particles at near-atomic detail, uncovering major structural differences between vaccine and virulent strains. The insights could lead to better vaccines and treatments for yellow fever and related mosquito-borne viruses.

The study reveals that widely used heart-attack risk calculators fail to flag nearly half of those who will soon experience a cardiac event. Even the newer PREVENT model misclassifies many patients as low-risk. Since most people develop symptoms only within 48 hours of their heart attack, current screening offers little time for intervention. Researchers say earlier detection with imaging could dramatically improve prevention.

Spermine, a small but powerful molecule in the body, helps neutralize harmful protein accumulations linked to Alzheimer’s and Parkinson’s. It encourages these misfolded proteins to gather into manageable clumps that cells can more efficiently dispose of through autophagy. Experiments in nematodes show that spermine also enhances longevity and cellular energy production. These insights open the door to targeted therapies powered by polyamines and advanced AI-driven molecular design.

Texas A&M researchers found a way to make stem cells produce double the normal number of mitochondria using nanoflower particles. These energized stem cells then transfer their surplus “power packs” to weakened cells, reviving their energy production and resilience. The method bypasses many limitations of current mitochondrial therapies and could offer long-lasting effects. It may open the door to treatments for aging tissues and multiple degenerative diseases.

A 20-year project in Bangladesh reveals that lowering arsenic levels in drinking water can slash death rates from major chronic diseases. Participants who switched to safer wells had the same risk levels as people who were never heavily exposed. The researchers tracked individual water exposure with detailed urine testing. Their results show how quickly health improves once contaminated water is replaced.

Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light chain, a marker of neuron injury. Low choline levels appeared closely tied to these changes. The results hint that early metabolic disruptions may quietly influence the brain long before symptoms emerge.

A massive veteran study found a strong connection between untreated sleep apnea and a higher chance of Parkinson’s. CPAP users had much lower odds of developing the condition. Researchers believe that repeated dips in oxygen during sleep may strain neurons over time. The results suggest that better sleep might help protect the brain.

Rheumatoid arthritis begins years before pain ever appears, and scientists have now mapped the hidden immune battle that unfolds long before symptoms. By studying people with RA-linked antibodies over seven years, researchers discovered sweeping inflammation, malfunctioning immune cells, and even epigenetic reprogramming in cells that had never encountered a threat. These changes show that the body is preparing for autoimmune attack long before joints become damaged.

Researchers at Stanford found a way to cure or prevent Type 1 diabetes in mice using a combined blood stem cell and islet cell transplant. The procedure creates a hybrid immune system that stops autoimmune attacks and eliminates the need for immune-suppressing drugs. The method uses tools already common in clinical practice, putting human trials within reach. Scientists think the same strategy could transform treatments for autoimmune conditions and organ transplantation.

Scientists discovered that lowered brain energy signaling in the hippocampus can lead to both depression- and anxiety-like behaviors in mice. Stress reduced ATP, a molecule important for cell energy and communication. Altering a protein called connexin 43, which helps release ATP, caused similar symptoms even without stress. Restoring this protein improved mood-related behavior.

Scientists discovered that more muscle and less hidden abdominal fat are linked to a younger biological brain age. Deep visceral fat appeared to accelerate brain aging, while muscle mass offered a protective effect.

Personalized algorithms may quietly sabotage how people learn, nudging them into narrow tunnels of information even when they start with zero prior knowledge. In the study, participants using algorithm-curated clues explored less, absorbed a distorted version of the truth, and became oddly confident in their wrong conclusions. The research suggests that this kind of digital steering doesn’t just shape opinions—it can reshape the very foundation of what someone believes they understand.

Scientists found that high-flavanol foods can prevent the decline in blood vessel function that occurs after prolonged sitting. Even physically fit men weren’t protected unless they had consumed flavanols beforehand. A cocoa drink rich in these compounds kept arteries functioning normally. Everyday foods like berries, apples, tea, and certain cocoa products could offer a simple way to protect long-term vascular health.

Scientists have found that a mutation tied to Alzheimer’s disrupts the production and quality of exosomes—tiny cell-made communication packets. Cells with the defective SORLA protein generate fewer exosomes and ones far less able to support nearby brain cells. This weakness may be a key driver of Alzheimer’s development. The research points to new treatment strategies that enhance or restore exosome function.