Medical and Health Sciences

Researchers found that fructose can prime immune cells to overreact to bacterial toxins. In healthy adults, fructose-sweetened drinks increased receptors that trigger inflammation. This heightened sensitivity may contribute to greater infection risk. The effects could be even more dangerous in people with metabolic diseases.

Researchers at UC Riverside have uncovered why soybean oil, one of America's most widely consumed ingredients, drives significant weight gain—at least in mice. The findings point not to the oil itself but to the fat-derived molecules it produces inside the body, called oxylipins, which can trigger inflammation, alter liver function, and influence genes tied to metabolism.

Scientists have uncovered how too much sunlight can flip a hidden switch inside skin cells that makes inflammation spiral out of control and increases the risk of cancer. Their research reveals that UV radiation breaks down a protective protein called YTHDF2, which normally prevents a small RNA signal from activating an immune sensor linked to dangerous inflammation. Once that protection is lost, a surprising chain reaction unfolds inside the cell, turning ordinary sun damage into a potential cancer trigger.

MIT scientists found that what we see is strongly influenced by how alert or active we are. Parts of the brain responsible for planning and control send specialized signals that either boost or quiet visual details. These areas seem to balance each other, sharpening important information while dimming distractions. The study shows vision is constantly being shaped by our internal state.

Scientists have uncovered a stepwise system that guides how the brain sorts and stabilizes lasting memories. By tracking brain activity during virtual reality learning tasks, researchers identified molecules that influence how long memories persist. Each molecule operates on a different timescale, forming a coordinated pattern of memory maintenance. The discoveries reshape how scientists understand memory formation.

Scientists found that RSV infection early in life can set the stage for childhood asthma, particularly in kids already genetically prone to allergies. The virus appears to skew the developing immune system toward exaggerated responses to everyday allergens. But when newborns were protected from RSV, asthma development was prevented. The results point to a powerful added benefit of RSV prevention tools now being rolled out globally.

Researchers have found that ongoing thyroid hormone imbalance in pregnancy may be linked to higher autism risk in children. Treated thyroid disorders did not show the same effect. The longer the imbalance lasted across trimesters, the more the risk appeared to rise. The study underscores the need for consistent thyroid monitoring.

Researchers studying thousands of canine genomes discovered that wolf DNA is still present in most dog breeds. This ancient genetic influence shows up in traits like body size, behavior, and environmental resilience. Even dogs bred far from wolves, including tiny chihuahuas, carry detectable wolf ancestry. The findings highlight how deeply intertwined the histories of dogs and wolves really are.

Millions face Medicare decisions each year, but many don’t take advantage of tools that can save them money and stress. Insurance marketing often overshadows unbiased options like SHIP, leaving people unaware of better choices. Comparing real costs—not just premiums—can prevent unpleasant surprises, especially when provider networks or drug rules change. New assistance programs for low-income adults offer valuable help for 2026.

Scientists have identified new anti-aging compounds produced by a little-studied blood bacterium. These indole metabolites were able to reduce inflammation, oxidative stress, and collagen-damaging activity in skin cell cultures. Three of the compounds, including two never seen before, showed particularly strong effects. The findings hint at a surprising new source for future skin-rejuvenation therapies.

Researchers analyzed data from over six million people to see how close residents lived to cannabis retailers. Neighborhoods near these shops experienced higher cannabis-related emergency visits compared with those farther away. The effect was strongest where multiple stores were packed into small areas. These trends suggest that store density plays a meaningful role in community health.

Researchers found that repeated head impacts can disrupt a key system that helps the brain wash away waste. In professional fighters, this system initially seems to work harder after trauma, then declines over time. MRI scans revealed that these changes may show up years before symptoms do. The work could help identify at-risk athletes earlier in their careers.

A large-scale Brazilian study found dangerous levels of toxic metals in popular children’s toys, with barium and lead topping the list. Researchers used sophisticated lab methods to identify 21 hazardous elements and test how easily they could be released when toys are mouthed. Even though only small fractions leach out, the total concentrations were so high that safety concerns remain critical.

A major review across 73 countries finds that access to antiseizure medications is rising, but safe prescribing isn’t keeping pace. Valproate—linked to serious birth defects—remains widely used in many regions despite WHO warnings. Limited access to newer drugs means millions may still be at risk. Researchers urge global education and stronger safeguards.

Princeton researchers found that the brain excels at learning because it reuses modular “cognitive blocks” across many tasks. Monkeys switching between visual categorization challenges revealed that the prefrontal cortex assembles these blocks like Legos to create new behaviors. This flexibility explains why humans learn quickly while AI models often forget old skills. The insights may help build better AI and new clinical treatments for impaired cognitive adaptability.

Data from over 47,000 dogs reveal that CBD is most often used in older pets with chronic health issues. Long-term CBD use was linked to reduced aggression, though other anxious behaviors didn’t improve. The trend was strongest among dogs whose owners lived in cannabis-friendly states.

Researchers discovered why bird flu can survive temperatures that stop human flu in its tracks. A key gene, PB1, gives avian viruses the ability to replicate even at fever-level heat. Mice experiments confirmed that fever cripples human-origin flu but not avian strains, especially those with avian-like PB1. These findings highlight how gene swapping could fuel future pandemics.

Long-term inhalation of toxic air appears to dull the protective power of regular workouts, according to a massive global study spanning more than a decade and over a million adults. While exercise still helps people live longer, its benefits shrink dramatically in regions with heavy fine particle pollution—especially above key PM2.5 thresholds common in many parts of the world. The researchers emphasize that outdoor activity shouldn’t stop, but better air quality could unlock far greater health gains.

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate stress-response pathways. Simulations show the damage makes mtDNA more rigid, possibly marking it for removal. The finding offers fresh clues to inflammation, aging, and diseases such as diabetes and neurodegeneration.

Warming up significantly improves muscle performance, particularly speed and power, by increasing muscle temperature. Both passive heat methods and light exercise warm-ups work, but mimicking the actual workout movements can offer extra benefits. When your body starts to feel coordinated and lightly sweaty, you’re ready to push into the main session.

Chronic cannabis use is increasingly linked to recurring bouts of vomiting, now officially classified as cannabis hyperemesis syndrome. The new ICD code helps doctors identify cases more consistently and gives researchers a clearer picture of how often it occurs. Patients often resist the diagnosis, and the condition’s causes remain murky. Relief can come from unusual sources like hot showers or capsaicin cream.

University of Queensland researchers visualized yellow fever virus particles at near-atomic detail, uncovering major structural differences between vaccine and virulent strains. The insights could lead to better vaccines and treatments for yellow fever and related mosquito-borne viruses.

The study reveals that widely used heart-attack risk calculators fail to flag nearly half of those who will soon experience a cardiac event. Even the newer PREVENT model misclassifies many patients as low-risk. Since most people develop symptoms only within 48 hours of their heart attack, current screening offers little time for intervention. Researchers say earlier detection with imaging could dramatically improve prevention.

Spermine, a small but powerful molecule in the body, helps neutralize harmful protein accumulations linked to Alzheimer’s and Parkinson’s. It encourages these misfolded proteins to gather into manageable clumps that cells can more efficiently dispose of through autophagy. Experiments in nematodes show that spermine also enhances longevity and cellular energy production. These insights open the door to targeted therapies powered by polyamines and advanced AI-driven molecular design.

Texas A&M researchers found a way to make stem cells produce double the normal number of mitochondria using nanoflower particles. These energized stem cells then transfer their surplus “power packs” to weakened cells, reviving their energy production and resilience. The method bypasses many limitations of current mitochondrial therapies and could offer long-lasting effects. It may open the door to treatments for aging tissues and multiple degenerative diseases.

A 20-year project in Bangladesh reveals that lowering arsenic levels in drinking water can slash death rates from major chronic diseases. Participants who switched to safer wells had the same risk levels as people who were never heavily exposed. The researchers tracked individual water exposure with detailed urine testing. Their results show how quickly health improves once contaminated water is replaced.

Scientists studying young adults with obesity discovered early indicators of brain stress that resemble patterns seen in cognitive impairment. The group showed higher inflammation, signs of liver strain and elevated neurofilament light chain, a marker of neuron injury. Low choline levels appeared closely tied to these changes. The results hint that early metabolic disruptions may quietly influence the brain long before symptoms emerge.

A massive veteran study found a strong connection between untreated sleep apnea and a higher chance of Parkinson’s. CPAP users had much lower odds of developing the condition. Researchers believe that repeated dips in oxygen during sleep may strain neurons over time. The results suggest that better sleep might help protect the brain.

Rheumatoid arthritis begins years before pain ever appears, and scientists have now mapped the hidden immune battle that unfolds long before symptoms. By studying people with RA-linked antibodies over seven years, researchers discovered sweeping inflammation, malfunctioning immune cells, and even epigenetic reprogramming in cells that had never encountered a threat. These changes show that the body is preparing for autoimmune attack long before joints become damaged.

Researchers at Stanford found a way to cure or prevent Type 1 diabetes in mice using a combined blood stem cell and islet cell transplant. The procedure creates a hybrid immune system that stops autoimmune attacks and eliminates the need for immune-suppressing drugs. The method uses tools already common in clinical practice, putting human trials within reach. Scientists think the same strategy could transform treatments for autoimmune conditions and organ transplantation.

Scientists discovered that lowered brain energy signaling in the hippocampus can lead to both depression- and anxiety-like behaviors in mice. Stress reduced ATP, a molecule important for cell energy and communication. Altering a protein called connexin 43, which helps release ATP, caused similar symptoms even without stress. Restoring this protein improved mood-related behavior.

Scientists discovered that more muscle and less hidden abdominal fat are linked to a younger biological brain age. Deep visceral fat appeared to accelerate brain aging, while muscle mass offered a protective effect.

Personalized algorithms may quietly sabotage how people learn, nudging them into narrow tunnels of information even when they start with zero prior knowledge. In the study, participants using algorithm-curated clues explored less, absorbed a distorted version of the truth, and became oddly confident in their wrong conclusions. The research suggests that this kind of digital steering doesn’t just shape opinions—it can reshape the very foundation of what someone believes they understand.

Ribosomes don’t just make proteins—they can sense when something’s wrong. When they collide, they send out stress signals that activate a molecule called ZAK. Researchers uncovered how ZAK recognizes these collisions and turns them into protective responses. The discovery shows how cells quickly spot trouble.

Scientists found that high-flavanol foods can prevent the decline in blood vessel function that occurs after prolonged sitting. Even physically fit men weren’t protected unless they had consumed flavanols beforehand. A cocoa drink rich in these compounds kept arteries functioning normally. Everyday foods like berries, apples, tea, and certain cocoa products could offer a simple way to protect long-term vascular health.

Participants lost more weight on a low-fat vegan diet than on the Mediterranean diet, largely due to eliminating animal foods and reducing oils and nuts. Increased intake of plant foods, even “unhealthy” ones, was strongly associated with greater weight loss.

Scientists are uncovering what makes some carcinomas so resistant: their ability to change identity. Two new studies reveal crucial proteins and structures that could become targets for future therapies. These discoveries deepen understanding of how tumors reprogram themselves and point toward highly specific treatments. The work raises hopes for safer, more selective cancer drugs.

Scientists have found that a mutation tied to Alzheimer’s disrupts the production and quality of exosomes—tiny cell-made communication packets. Cells with the defective SORLA protein generate fewer exosomes and ones far less able to support nearby brain cells. This weakness may be a key driver of Alzheimer’s development. The research points to new treatment strategies that enhance or restore exosome function.

Hypertension begins harming the brain surprisingly early, even before measurable blood pressure increases. Key cells related to blood vessels, signaling, and myelin maintenance begin aging prematurely and malfunctioning. These disruptions resemble early patterns seen in cognitive decline and Alzheimer’s. Encouragingly, losartan reversed some of this early damage in mice.

A research team has found that specific immune cells can connect with muscle fibers in a lightning-fast, neuron-like way to promote healing. These cells deliver quick pulses of calcium, triggering repair within seconds. The mechanism works in both injury and disease models. The discovery could inspire new treatments for muscle recovery and degeneration.

A massive long-term study shows that Mediterranean and plant-based diets can help prevent chronic constipation in aging adults. Surprisingly, the benefits weren’t explained by fiber alone. Western and inflammatory diets raised constipation risk, while low-carb diets showed minimal impact. The research underscores how diet quality influences gut health well beyond traditional advice.

Ultra-processed foods are rapidly becoming a global dietary staple, and new research links them to worsening health outcomes around the world. Scientists say only bold, coordinated policy action can counter corporate influence and shift food systems toward healthier options.

Researchers have uncovered a surprising new role for the HSL protein: beyond breaking down fat, it also works inside the nucleus of fat cells to keep them functioning properly. When HSL is missing, fat tissue doesn’t expand as expected— instead, it shrinks, leading to lipodystrophy. This unexpected discovery helps explain why both obesity and fat-loss disorders share similar health risks, and it opens up fresh paths for understanding metabolic diseases at a time when obesity affects billions worldwide.

Scientists have uncovered how leukemia cells manage to escape one of the most commonly used treatments. Over time, these cancer cells subtly change the shape of their mitochondria to avoid dying when the drug tries to kill them. By identifying the protein that controls this shape-shifting, researchers were able to block it in mice, making the treatment powerful again and dramatically extending survival.

Researchers have uncovered a surprising way the brain switches pain on, revealing that neurons can release an enzyme outside the cell that activates pain signals without disrupting normal movement or sensation. This enzyme, called VLK, modifies nearby proteins in a way that intensifies pain and strengthens connections tied to learning and memory. Removing VLK in mice dramatically reduced post-surgery pain while leaving normal function untouched, offering a promising path toward safer, more targeted pain treatments.

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at different points, researchers can now watch damage flare up, track repair proteins rushing to the site, and see the moment the DNA is restored. Built from a natural protein that binds gently and briefly to damaged DNA, the sensor offers a true-to-life view of the cell’s internal emergency response.

Researchers discovered that raising the protein Sox9 can help the brain’s astrocytes clear out toxic plaque buildup linked to Alzheimer’s. In mouse models that already showed memory problems, activating these cells improved cognitive performance. The treatment also reduced plaque levels over time. The work points toward a natural, cell-based way to slow Alzheimer’s decline.

Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an outsized ability to keep the brain healthier. When a key signal is removed from them, Alzheimer’s symptoms worsen. This pathway may help explain why some people naturally have reduced Alzheimer’s risk.

A new nasal-delivered nanotherapy shows promise against aggressive glioblastoma tumors. By activating the STING immune pathway using gold-core spherical nucleic acids, researchers were able to reach the brain without invasive surgery. When paired with drugs that boost T-cell activity, the treatment eliminated tumors in mice and built long-lasting immunity. The results suggest a powerful new direction for brain cancer immunotherapy.

A first-of-its-kind trial is testing adult stem cell transplants for advanced dry macular degeneration. Early results show the treatment is safe and can significantly improve vision, even in severely affected patients. Participants gained measurable sight improvements in the treated eye. Researchers are now monitoring higher-dose groups as the therapy advances toward later trial phases.

People who smoke only a couple of cigarettes a day still face surprisingly high risks of heart problems and early death. A large review of long-term studies shows that even very light smokers can see their risk of heart failure climb sharply. While quitting leads to major health improvements, some risk remains for decades. The safest approach is quitting entirely, especially at younger ages.

Researchers uncovered how estrogen subtly reshapes learning by strengthening dopamine reward signals in the brain. Rats learned faster when estrogen levels were high and struggled when the hormone’s activity was blocked. The findings help explain how hormonal cycles influence cognitive performance and psychiatric symptoms. This connection offers a new path for understanding brain disorders tied to dopamine.

A massive real-world study comparing tirzepatide and semaglutide reveals both drugs deliver strong, early cardiovascular protection—reducing heart attack, stroke, and death in adults with type 2 diabetes. While companies have claimed large differences favoring their own medications, researchers found only modest distinctions between the two blockbuster GLP-1 drugs.

Researchers discovered that the common amino acid arginine can block harmful Aβ aggregation and reduce its toxic effects in Alzheimer’s disease models. In flies and mice, oral arginine lowered plaque levels, reduced inflammation, and improved behavior. Its strong safety record and low cost make it a promising repurposing candidate. The findings hint at a surprisingly simple path toward more accessible AD therapies.

Researchers discovered that chemotherapy can accidentally trigger a stress alarm in immune cells, causing inflammation that damages nerves. Blocking this alarm protected mice from nerve pain and kept their nerves healthier. A drug already being tested for cancer may help do the same in people. Early blood tests suggest it may even be possible to predict who will develop these symptoms before they happen.

A new airflow device from UBC Okanagan engineers traps exhaled aerosols almost immediately, sharply reducing pathogen exposure in indoor spaces. Early simulations suggest it could outperform existing ventilation systems by a wide margin.

Tiny ingestible spheres filled with engineered bacteria can detect intestinal bleeding by glowing when they encounter heme. Early tests in mice suggest they could become a quick, noninvasive way to monitor gut disease.

Researchers have recreated a miniature human bone marrow system that mirrors the real structure found inside our bones. The model includes the full mix of cells and signals needed for blood production and even maintains this process for weeks. It could transform how scientists study blood cancers and test new drugs. In the future, it may support more personalized treatment strategies.

Researchers discovered a way to keep T cells from wearing out during the fight against cancer, and the approach could make immune-based treatments far more powerful. They found that tumors use a particular molecular signal to weaken T cells, and that interrupting this signal helps the cells stay active.

Researchers found that hot tubs raise core body temperature more effectively than traditional or infrared saunas, leading to stronger boosts in blood flow and immune activity. Only hot-water immersion produced measurable changes in inflammatory markers. These effects can persist beyond the session, suggesting a sustained health benefit. For anyone unable or unwilling to exercise, heat therapy may offer a surprisingly effective option.