Heart Disease

Researchers used a deep learning AI model to uncover the first imaging-based biomarker of chronic stress by measuring adrenal gland volume on routine CT scans. This new metric, the Adrenal Volume Index, correlates strongly with cortisol levels, allostatic load, perceived stress, and even long-term cardiovascular outcomes, including heart failure risk.

Researchers found that both how often and how much someone drinks significantly shape their cancer risk, even at moderate levels. Vulnerability varies across groups, with genetics, socioeconomic status, obesity, and lifestyle behaviors amplifying harm. The review also uncovered gender differences, beverage-specific risks, and biological pathways that intensify cancer development.

New research is challenging one of medicine’s oldest assumptions: that cancer must be attacked to be cured. By treating glioblastoma patients with a simple combination of resveratrol and copper, the researchers found dramatic reductions in tumor aggressiveness, cancer biomarkers, immune checkpoints, and stem-cell–related markers—all without side effects. Their approach focuses on “healing” tumors by eliminating harmful cell-free chromatin particles released from dying cancer cells, which normally inflame and worsen the disease. The findings hint at a future where inexpensive nutraceuticals could transform cancer therapy.

The study reveals that widely used heart-attack risk calculators fail to flag nearly half of those who will soon experience a cardiac event. Even the newer PREVENT model misclassifies many patients as low-risk. Since most people develop symptoms only within 48 hours of their heart attack, current screening offers little time for intervention. Researchers say earlier detection with imaging could dramatically improve prevention.

Scientists found that high-flavanol foods can prevent the decline in blood vessel function that occurs after prolonged sitting. Even physically fit men weren’t protected unless they had consumed flavanols beforehand. A cocoa drink rich in these compounds kept arteries functioning normally. Everyday foods like berries, apples, tea, and certain cocoa products could offer a simple way to protect long-term vascular health.

Microplastics—tiny particles now found in food, water, air, and even human tissues—may directly accelerate artery-clogging disease, and new research shows the danger may be far greater for males. In mice, environmentally realistic doses of microplastics dramatically worsened plaque buildup, altered key vascular cells, and activated harmful genes linked to inflammation and atherosclerosis, all without changes to weight or cholesterol.

Chronic pain might quietly push people toward developing high blood pressure—and the more widespread the pain, the greater the danger. A massive analysis of over 200,000 adults uncovered strong links between long-lasting pain, depression, inflammation, and rising hypertension risk.

Scientists have discovered that most chronic fatigue patients experience dysfunctional breathing, which may worsen their symptoms. The likely culprit is dysautonomia, a disruption in how the body controls blood vessels and muscles. Breathing retraining, yoga, or biofeedback could help restore proper breathing rhythm and ease fatigue. The findings open a promising new path for managing this long-misunderstood illness.

Most U.S. adults don’t realize alcohol raises cancer risk, and drinkers themselves are the least aware. Scientists say targeting these misbeliefs could significantly reduce alcohol-related cancer deaths.

Boston researchers linked nighttime light exposure to greater stress-related brain activity and inflamed arteries, signaling a higher risk of heart disease. The study suggests that artificial light at night disrupts normal stress responses, leading to chronic inflammation. Experts call for reducing unnecessary light in cities and homes to protect cardiovascular health.

Semaglutide, tirzepatide, and other GLP-1 drugs appear to slow alcohol absorption and blunt its intoxicating effects, according to new research. The study found participants on these medications felt less drunk despite consuming the same amount of alcohol. This could point to a safer, faster-acting way to help people reduce drinking—distinct from traditional treatments that target the brain directly.

A new pill called baxdrostat may offer hope for people whose blood pressure stays high even after taking standard medications. In a recent study, the drug lowered blood pressure and also seemed to protect the kidneys by reducing signs of damage. Doctors say this could help millions of people with chronic kidney disease, a condition that often makes blood pressure harder to control.

Addiction often isn’t about chasing pleasure—it’s about escaping pain. Researchers at Scripps Research have discovered that a tiny brain region called the paraventricular nucleus of the thalamus (PVT) becomes hyperactive when animals learn that alcohol eases the agony of withdrawal. This circuit helps explain why people relapse: their brains learn that alcohol brings relief from stress and anxiety.

A massive new study combining observational and genetic data overturns the long-held belief that light drinking protects the brain. Researchers found that dementia risk rises in direct proportion to alcohol consumption, with no safe level identified.

A new wearable device, a-Heal, combines AI, imaging, and bioelectronics to speed up wound recovery. It continuously monitors wounds, diagnoses healing stages, and applies personalized treatments like medicine or electric fields. Preclinical tests showed healing about 25% faster than standard care, highlighting potential for chronic wound therapy.

Researchers discovered that Covid accelerates blood vessel aging by about five years, especially in women. Even mild infections increased arterial stiffness, with vaccinated individuals showing less damage. This vascular aging may raise long-term heart and stroke risk.

A new gel-based treatment could change the way diabetic wounds heal. By combining tiny healing messengers called vesicles with a special hydrogel, scientists have created a dressing that restores blood flow and helps wounds close much faster. In tests, the treatment healed diabetic wounds far quicker than normal, while also encouraging the growth of new blood vessels. Researchers believe this innovation could one day help millions of people with slow-healing wounds caused by diabetes and possibly other conditions.

Potent statins are the best-proven weapon against heart disease, especially when paired with lifestyle changes. Most people aren’t active enough—and many are underdiagnosed—so starting treatment strong is key.

President Trump s diagnosis of Chronic Venous Insufficiency (CVI) has brought renewed attention to a frequently overlooked yet dangerous condition. CVI affects the ability of veins especially in the legs to return blood to the heart, often leading to swelling, pain, skin changes, and ulcers. The American Heart Association warns that CVI isn t just a cosmetic issue; it's strongly linked to cardiovascular disease and increased mortality, even when other risk factors are accounted for. Seniors, smokers, those with sedentary lifestyles, and people with obesity are particularly at risk.

An advanced Johns Hopkins AI model called MAARS combs through underused heart MRI scans and complete medical records to spot hidden scar patterns that signal sudden cardiac death, dramatically outperforming current dice-roll clinical guidelines and promising to save lives while sparing patients unnecessary defibrillators.

Washington University researchers found that raising a molecule called ApoM helps eye cells sweep away harmful cholesterol deposits linked to age-related macular degeneration, potentially preventing vision loss, and the same trick might aid failing hearts too.

USC researchers have uncovered a hidden driver behind the early and severe onset of Alzheimer's in people with Down syndrome: iron overload in the brain. Their study revealed that individuals with both conditions had twice the iron levels and far more oxidative damage than others. The culprit appears to be ferroptosis, an iron-triggered cell death mechanism, which is especially damaging in sensitive brain regions.

Scientists have discovered that people with COPD have lung cells that contain over three times as much soot-like carbon as those of smokers without the disease. These overloaded cells are larger and trigger more inflammation, suggesting that pollution and carbon buildup not just smoking may drive the disease.

Genetic research in Sweden has unveiled three new gene variants that dramatically increase the risk of venous blood clots, sometimes by up to 180%. These discoveries build on existing knowledge of Factor V Leiden and suggest that genetics plays a bigger role than previously thought, especially for clots in the legs that can lead to life-threatening pulmonary embolisms.

A new risk calculator accurately identified participants who had calcium buildup in their heart arteries and those who had a higher future heart attack risk, in an analysis of about 7,000 adults in New York City referred for heart disease screening.

Spending too much time sitting after a heart scare could be deadly. New research shows that patients who were sedentary for more than 14 hours a day in the month after leaving the hospital had a sharply higher chance of suffering another heart problem or even dying within a year. But there’s good news: simply replacing 30 minutes of sitting with light activities like walking around the house—or even more sleep—cut risks dramatically, in some cases by more than half.

Palliative care is specialized medical care focused on easing symptoms, addressing psychological and spiritual needs, and helping patients and caregivers make critical decisions aligned with their personal beliefs and values.

A new study puts the spotlight on the rising burden of ischemic heart disease across Southeast Asia, East Asia and Oceania, and calls for localized, equity-focused interventions in these regions. The researchers identified region-specific, modifiable risk factors that influence the increasing prevalence of ischemic heart disease, such as toxic air pollution in East Asia and ultra-processed dietary dependence in Oceania.

Researchers have developed a novel rat model that closely replicates the pathological features and physiological changes associated with human chronic obstructive pulmonary disease (COPD)-associated cor pulmonale. This model exhibits key characteristics, including chronic lung inflammation, pulmonary hypertension, and right ventricular hypertrophy. The new study details the potential for the model to unravel the complex interactions between lung and heart pathology and improve patient outcomes.

Investigators have discovered a new pathway that may lead to a treatment for high blood pressure and aortic aneurysms. By creating a new laboratory model for studying these conditions, the team treated hypertension and aortic aneurysms by targeting a protein that they discovered to be involved in the vascular cells' response to oxidative stress.

A massive study of 200,000 people shows that counting the actual number of cholesterol-carrying particles (apoB) predicts heart attack risk far better than the traditional cholesterol test. Add in a second marker, lipoprotein(a), and doctors may soon have a sharper tool to catch hidden risks before it’s too late.

A small study found that fatty buildup in the blood vessels of the neck (carotid arteries) may contain 50 times or more micronanoplastics -- minuscule bits of plastic -- compared to arteries free of plaque buildup.

A preclinical study finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity -- two issues that commonly co-occur with alcohol use disorder (AUD).

Among adults ages 18-49 (median age of 41 years) who were born with a hole in the upper chambers of their heart known as patent foramen ovale (PFO), strokes of unknown cause were more strongly associated with nontraditional risk factors, such as migraines, liver disease or cancer, rather than more typical factors such as high blood pressure.

A new study could lead to more widespread use of imaging technique to improve survival and prevent complications.

Healthy sleep includes multiple components, such as number of hours of sleep per night, how long it takes to fall asleep, daytime functioning and self-reported sleep satisfaction, and addressing these different dimensions of sleep may help to reduce cardiometabolic health and related risk factors, according to a new scientific statement.

A new study suggests that perceived stress and depression factor into the relationship between insomnia and hazardous drinking -- perhaps not a surprise. But because the relationship between insomnia and heavy drinking goes in both directions, the influence of stress or depression depends on which condition came first, the analysis found.

For the first time researchers demonstrate in an animal how heavy alcohol use leads to long-term behavioral issues by damaging brain circuits critical for decision-making.

Smaller than a grain of rice, new pacemaker is particularly suited to the small, fragile hearts of newborn babies with congenital heart defects. Tiny pacemaker is paired with a small, soft, flexible wearable patch that sits on the patient's chest. The wearable patch detects irregular heartbeats and automatically emits pulses of light. The light then flashes on and off at a rate that corresponds to the correct pacing. After the tiny pacemaker is no longer needed, it dissolves inside the body.

Linoleic acid, an omega-6 fatty acid found in seed oils such as soybean and safflower oil, and animal products including pork and eggs, specifically enhances the growth of the hard-to-treat 'triple negative' breast cancer subtype, according to a preclinical study. The discovery could lead to new dietary and pharmaceutical strategies against breast and other cancers.

Public awareness of the link between drinking alcohol and an elevated risk of cancer has grown since last fall, with 55% of U.S. adults saying that regularly consuming alcohol increases your chances of later developing cancer, according to a new survey.

New findings indicate that while the rate of marathon runners who suffer cardiac arrests remained unchanged, their chance for survival is twice what it was in the past. Now, far fewer marathon runners who suffer cardiac arrest are dying of it.

Mammograms, with the help of artificial intelligence (AI) models, may reveal much more than cancer, according to a new study. The findings highlight how these important cancer screening tools can also be used to assess the amount of calcium buildup in the arteries within breast tissue -- an indicator of cardiovascular health.

For women in their 80s, experiencing increasing sleepiness during the day over a five-year period is associated with double the risk of developing dementia during that time, according to a new study. The study does not prove that daytime sleepiness causes dementia; it only shows an association.

Scientists have developed an approach that combines rehabilitation robotics with spinal cord stimulation to restore movement in people with spinal cord injuries. The technology enhances rehabilitation and enables activities like cycling and walking outdoors.

A novel analysis of more than 375 published studies concluded that the association between chronic pain and rates of depression and anxiety is staggering. The study found that 40% of adults with chronic pain experienced 'clinically significant depression and anxiety.' Among those most at risk, the analysis showed, were women, younger adults and people with fibromyalgia.

Some people living with chronic stress have a higher risk of stroke, according to a new study. The study looked at younger adults and found an association between stress and stroke, with no known cause, in female participants, but not male participants. This study does not prove that stress causes stroke; it only shows an association.

Shared decision-making between clinicians and athletes of all ages who have cardiovascular abnormalities and want to participate in competitive sports is essential, according to a new joint scientific statement.

One in five older adults gets an infection up to six months after heart surgery, and women are far more likely to develop one, according to recent studies. Black patients also had higher rates of overall infection compared to white patients. Researchers say estimates of postoperative infections are likely vastly underestimated.

South Asian adults in the United Kingdom may face high blood pressure-related heart risks earlier in life, while East Asian adults see risks rise in later years, according to a new study.

A revolutionary new treatment called Targeted Thermal Therapy (Tripel T) offers a safer, faster alternative to surgery for patients with high blood pressure caused by Primary Aldosteronism, a hormonal disorder.

A team of physicists has developed a groundbreaking method for detecting congestive heart failure with greater ease and precision than previously thought possible. This multidisciplinary study, involving both cardiologists and computational physicists, builds on the team's earlier breakthroughs, for example, in predicting the risk of sudden cardiac death.

Research in fruit flies has identified specific groups of cholinergic brain cells that are involved in alcohol-induced insomnia. This work could ultimately lead to targeted treatments for alcohol-related sleep loss, helping people recover from alcohol use disorder.

Propranolol, a beta blocker medication used for treating high blood pressure and preventing migraines, may lower ischemic stroke risk in women who experience migraines frequently.

People with brain bleeds had nearly 7 times higher blood levels of a specific brain protein, called glial fibrillary acidic protein (GFAP), than those who had strokes caused by clots in a study conducted in Germany.

By integrating 30 minutes a day of progressive walking exercise into standard stroke rehabilitation (30 to 60 minutes of physical therapy five days a week) stroke patients had a measurable improved quality of life and mobility at hospital discharge compared to a control group.

People who regularly floss their teeth (one or more times per week) may lower their risk of stroke caused by a blood clot traveling from the heart and a stroke associated with an irregular heartbeat such as atrial fibrillation (AFib).

A new study has highlighted the potential of resveratrol, a natural compound found in grapes, blueberries, and raspberries, to enhance female fertility. The systematic review found that resveratrol can improve the quantity and quality of egg cells, offering hope for new, less invasive fertility treatments.

People with pockets of fat hidden inside their muscles are at a higher risk of dying or being hospitalized from a heart attack or heart failure, regardless of their body mass index, according to new research. This 'intermuscular' fat is highly prized in beef steaks for cooking. However, little is known about this type of body fat in humans, and its impact on health. This is the first study to comprehensively investigate the effects of fatty muscles on heart disease. The new finding adds evidence that existing measures, such as body mass index or waist circumference, are not adequate to evaluate the risk of heart disease accurately for all people.

Developing rice with tolerance to higher nighttime temperatures has become a focus for rice breeders because studies are showing nights are getting warmer in rice-growing regions. Vibha Srivastava, professor of plant biotechnology in the crop, soil and environmental sciences department for the University of Arkansas System Division of Agriculture, explores the topic of breeding rice and the potential for gene editing to tolerate night heat in the December issue of Current Opinion in Plant Biology with an article titled 'Beat the heat: Breeding, genomics, and gene editing for high nighttime temperature tolerance in rice.'